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16

抑制剂 & 化合物

22

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35904	O-11
	O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface gl...
T17919	Thalidomide-O-amido-C6-NH2 TFA E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate,Cereblon Ligand-Linker Conjugates 11 TFA,E3 Ligase Ligand-Linker Conjugates 25 TFA	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物。可用于 PROTAC 的合成分子。
T39361	Thalidomide-O-amido-C6-NH2 E3LigaseLigand-LinkerConjugates25,Cereblon Ligand-Linker Conjugates 11,Thalidomide-O-amido-C6-NH2
	Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11) is a Thalidomide-based synthetic E3 ligase ligand-linker conjugate, comprising of a cereblon ligand and a linker. This compound is employed in the production of PROTACs (proteolysis-targeting chimeras).
T75769	[Sar9,Met(O2)11]-Substance P TFA
	[Sar9,Met(O2)11]-Substance P TFA 是一种选择性的速激肽NK1受体激动剂。
T77958	Thalidomide-5-O-C11-NH2 hydrochloride
	Thalidomide-5-O-C11-NH2 hydrochloride是一款基于Thalidomide的cereblon配体，能够招募CRBN蛋白。该化合物通过linker与靶向蛋白配体结合，用于构建PROTAC分子，如THAL-SNS-032。
T77962	Thalidomide-4-O-C11-NH2 hydrochloride
	Thalidomide-4-O-C11-NH2 hydrochloride是Thalidomide衍生的cereblon配体，能够募集CRBN蛋白。该化合物能够利用linker与目标蛋白配体结合，进而形成PROTAC分子，如THAL-SNS-032。
TP1932	[D-Trp7,9,10]-Substance P
	Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.
T123878	6-O-(2-Methylbutyryl)helenalin
	6-O-(2-Methylbutyryl)helenalin 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T123878，CAS号为 94729-11-0。
T66067	2′,3′-O-Isopropylideneinosine
	2′,3′-O-Isopropylideneinosine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66067，CAS号为 2140-11-6。
T67323	5'-O-(Tert-butyldimethylsilyl)-5-iodo-2'-deoxycytidine
	5'-O-(Tert-butyldimethylsilyl)-5-iodo-2'-deoxycytidine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67323，CAS号为 666848-11-9。
T29186	YM49598 YM-49598,YM 49598
	YM49598 is a tachykinin receptor antagonist. YM49598 exhibited high binding affinities at NK(1) (pK(i) = 9.09 +/- 0.02) and NK(2) (pK(i) = 9.94 +/- 0.03) receptors, respectively. YM49598 was almost inactive but produced a potent inhibition (IC(50) = 11 +/
T38167	BE-24566B
	BE-24566B is a polyketide fungal metabolite originally isolated fromS. violaceusniger.1It is active againstB. subtilis,B. cereus,S. aureus,M. luteus,E. faecalis, andS. thermophilus(MICs = 1.56, 1.56, 1.56, 1.56, 3.13, and 3.13 μg/ml, respectively). BE-24566B is an endothelin (ET) receptor antagonist (IC50s = 11 and 3.9 μM for ETAand ETBreceptors, respectively).2 1.Kojiri, K., Nakajima, S., Fuse, A., et al.BE-24566B, a new antibiotic produced by Streptomyces violaceusnigerJ. Antibiot. (Tokyo)48(1...
T36418	O-Desmethyl-N-deschlorobenzoyl Indomethacin
	O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism ...
T35929	O-Demethyl Apremilast
	O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 μM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3 1.Hoffmann, M., Kumar, G., Schafer, P., et al.Disposition, metabolism and mass balance of [14C]apremilast following oral admi...
T36616	DTUN
	DTUN is a lipophilic hyponitrite radical initiator.1It initiates co-autoxidation of STY-BODIPY-embedded egg phosphatidylcholine liposomes when used at a concentration of 0.2 mM. DTUN has been used in fluorescence-enabled inhibited autoxidation (FENIX) assays for the development of ferroptosis inhibitors and the study of antioxidants in lipid membranes.1,2 1.Shah, R., Farmer, L.A., Zilka, O., et al.Beyond DPPH: Use of fluorescence-enabled inhibited autoxidation to predict oxidative cell death res...
T36176	AMK (hydrochloride)
	AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7...

化合物

Cat.No: T35904

Thalidomide-O-amido-C6-NH2 TFA

Cat.No: T17919

Synonym: E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate,Cereblon Ligand-Linker Conjugates 11 TFA,E3 Ligase Ligand-Linker Conjugates 25 TFA

Target: Others, Ligand for E3 Ligase

Thalidomide-O-amido-C6-NH2

Cat.No: T39361

Synonym: E3LigaseLigand-LinkerConjugates25,Cereblon Ligand-Linker Conjugates 11,Thalidomide-O-amido-C6-NH2

[Sar9,Met(O2)11]-Substance P TFA

Cat.No: T75769

Thalidomide-5-O-C11-NH2 hydrochloride

Cat.No: T77958

Thalidomide-4-O-C11-NH2 hydrochloride

Cat.No: T77962

[D-Trp7,9,10]-Substance P

Cat.No: TP1932

6-O-(2-Methylbutyryl)helenalin

Cat.No: T123878

2′,3′-O-Isopropylideneinosine

Cat.No: T66067

5'-O-(Tert-butyldimethylsilyl)-5-iodo-2'-deoxycytidine

Cat.No: T67323

Cat.No: T29186

Synonym: YM-49598,YM 49598

Cat.No: T38167

O-Desmethyl-N-deschlorobenzoyl Indomethacin

Cat.No: T36418

O-Demethyl Apremilast

Cat.No: T35929

Cat.No: T36616

AMK (hydrochloride)

Cat.No: T36176

Cat. No.	Product Name	Target	Signaling Pathways
T3832	11-O-Galloylbergenin	Antioxidant; Immunology/Inflammation related	Immunology/Inflammation; oxidation-reduction
	11-O-Galloylbergenin 是从 Mallotus philippinensis 中分离出来的，具有抗氧化和抗疟原虫活性。
TN1255	3-O-Acetyl-11-hydroxy-beta-boswellic acid	Lipoxygenase	Metabolism
	3-O-Acetyl-11-hydroxy-beta-boswellic acid 是 5-脂氧合酶抑制剂。
TN6910	Aloinoside B 11-o-Rhamnosylaloin B
	Aloinoside B (11-o-Rhamnosylaloin B) 是一种来自芦荟的糖苷。
T5S1569	AKBA 乙酰基-11-酮基-beta-乳香酸,3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid	Others; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite	Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Others
	AKBA (3-O-Acetyl-11-keto-beta-boswellic acid) 是一种从乳香中分离的天然成分，是新颖的 Nrf2 的活化剂。
TN1183	11-Oxomogroside III 11-Oxomogroside III,11-O-罗汉果苷III	Others	Others
	11-Oxomogroside III is a natural product from Siraitia grosvenorii Swingle.
T5711	Methylnissolin-3-O-glucoside (6aR, 11 aR)-3-hydroxy-9,l0-diMethoxy pt,美迪紫檀苷,黄芪异黄烷苷,7,2'-二羟基-3',4'-二甲氧基异黄烷	Others	Others
	Methylnissolin-3-O-glucoside ((6aR, 11 aR)-3-hydroxy-9,l0-diMethoxy pt) 是一种类黄酮，从黄芪的根中获得，具有抗炎活性。
T2S1841	3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B 11-O-异丁酰基-12-O-乙酰基通关藤甘元B-3-O-茯苓二糖基,Tenacigenin B, 3-O-β-Allopyranosyl-(1→4),通关藤苷B	Others	Others
	Tenacigenin B, 3-O-β-Allopyranosyl-(1→4) 是植物茯苓Poria cocos 的成分之一。
TN6201	(1R,6R,9R)-6,9,11-Trihydroxy-4,7-megastigmadien-3-one 11-O-glucoside
	(1R,6R,9R)-6,9,11-Trihydroxy-4,7-megastigmadien-3-one 11-O-glucoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6201，CAS号为 289914-68-7。
T83462	11-O-Syringylbergenin
	11-O-Syringylbergenin为自龙骨草全草中分离出的岩白菜素类衍生物。
T62625	11-O-Methylpseurotin A
	11-O-Methylpseurotin A为一种(PKS/NRPS)混合聚酮合成酶-非核糖体肽合成酶化合物，其特性为选择性抑制Hof1缺失菌株。
T83460	11-O-β-D-glucopyranosyl thamnosmonin
	11-O-β-D-glucopyranosyl thamnosmonin是一种香豆素苷，能够从Angelica apaensis根部提取。该化合物对PAF、AA和ADP诱发的兔血小板聚集表现出轻度的抑制效果。
T83459	11α-O-Tigloyl-12β-O-acetyltenacigenin B	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	11α-O-Tigloyl-12β-O-acetyltenacigenin B 是Tenacigenin B 的酯类衍生物，源自藤黄藤 (MTC)。该化合物具有调节Aurora-A活性，对淋巴瘤显示出潜在的抗肿瘤效果。
TN1184	11-Oxomogroside IIIE	Others	Others
	11-Oxomogroside IIIE is a natural product
TN1185	11-Oxomogroside IV	Others	Others
	11-Oxomogroside IV is a natural product
T6S0095	Genkwanin 7-O-Methylapigenin,Puddumetin,Apigenin 7-methyl ether,芫花素	Virus Protease	Microbiology/Virology
	Genkwanin (Apigenin 7-methyl ether) 是一种O-甲基化黄酮，有抗炎活性，通过被动扩散和多药耐药蛋白介导的外排机制转运。
TN2153	Rhaponticin 6′′-O-gallate 土大黄苷 6''-O-没食子酸酯,Rhaponticin 6''-O-gallate	Others	Others
	Rhaponticin 6''-O-gallate showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages, (IC50 = 11-69 microM).
TN2152	Rhaponticin 2′′-O-gallate 土大黄苷 2''-O-没食子酸酯,Rhaponticin 2''-O-gallate	Others	Others
	Rhaponticin 2''-O-gallate showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages, (IC50 = 11-69 microM).
T83104	Anthragallol 1,2-dimethyl ether
	Anthragallol 1,2-dimethyl ether 可从O. umbellata提取。该化合物对A549细胞和MDA-MB-231细胞展现细胞毒性，IC50值分别为5.9 μg/ml和8.8 μg/ml。
T75566	11-Oxomogroside II A1
	11-Oxomogroside II A1（化合物 7）是一种从罗汉果乙醇提取物中分离的氧化葫芦苷，对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）活化具有抑制效果，并对一氧化氮（NO）供体（+/-）-(E)-甲基-2-[(E)羟基亚氨基]-5-硝基-6-甲氧基-3-己酰胺（NOR 1）的活化也展示出轻微的抑制作用。
TN1938	Mogroside VI 罗汉果甜苷 VI,罗汉果甜苷VI	Antifection	Microbiology/Virology
	Lo Han Kuo extract is a high intensive sweetening agent with desirable health benefits, such as prevention of dental caries through specific antibacterial properties, no-calorie levels related to obesity, and a low glycemic index to help manage blood suga
T35609	19-O-Acetylchaetoglobosin A
	19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ...
T36179	Aspulvinone O
	Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM).2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) redu...

天然产物

11-O-Galloylbergenin

Cat.No: T3832

Target: Antioxidant, Immunology/Inflammation related

3-O-Acetyl-11-hydroxy-beta-boswellic acid

Cat.No: TN1255

Target: Lipoxygenase

Cat.No: TN6910

Synonym: 11-o-Rhamnosylaloin B

Cat.No: T5S1569

Synonym: 乙酰基-11-酮基-beta-乳香酸,3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid

Target: Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite

11-Oxomogroside III

Cat.No: TN1183

Synonym: 11-Oxomogroside III,11-O-罗汉果苷III

Target: Others

Methylnissolin-3-O-glucoside

Cat.No: T5711

Synonym: (6aR, 11 aR)-3-hydroxy-9,l0-diMethoxy pt,美迪紫檀苷,黄芪异黄烷苷,7,2'-二羟基-3',4'-二甲氧基异黄烷

Target: Others

3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B

Cat.No: T2S1841

Synonym: 11-O-异丁酰基-12-O-乙酰基通关藤甘元B-3-O-茯苓二糖基,Tenacigenin B, 3-O-β-Allopyranosyl-(1→4),通关藤苷B

Target: Others

(1R,6R,9R)-6,9,11-Trihydroxy-4,7-megastigmadien-3-one 11-O-glucoside

Cat.No: TN6201

11-O-Syringylbergenin

Cat.No: T83462

11-O-Methylpseurotin A

Cat.No: T62625

11-O-β-D-glucopyranosyl thamnosmonin

Cat.No: T83460

11α-O-Tigloyl-12β-O-acetyltenacigenin B

Cat.No: T83459

Target: Aurora Kinase

11-Oxomogroside IIIE

Cat.No: TN1184

Target: Others

11-Oxomogroside IV

Cat.No: TN1185

Target: Others

Cat.No: T6S0095

Synonym: 7-O-Methylapigenin,Puddumetin,Apigenin 7-methyl ether,芫花素

Target: Virus Protease

Rhaponticin 6′′-O-gallate

Cat.No: TN2153

Synonym: 土大黄苷 6''-O-没食子酸酯,Rhaponticin 6''-O-gallate

Target: Others

Rhaponticin 2′′-O-gallate

Cat.No: TN2152

Synonym: 土大黄苷 2''-O-没食子酸酯,Rhaponticin 2''-O-gallate

Target: Others

Anthragallol 1,2-dimethyl ether

Cat.No: T83104

11-Oxomogroside II A1

Cat.No: T75566

Cat.No: TN1938

Synonym: 罗汉果甜苷 VI,罗汉果甜苷VI

Target: Antifection

19-O-Acetylchaetoglobosin A

Cat.No: T35609

Cat.No: T36179

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