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Search Results for " non-peptidic "

16

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7476	AS057278 3-Methylpyrazole-5-carboxylic acid,5-甲基-1H-吡唑-3-羧酸	Others	Others
	AS057278 (3-Methylpyrazole-5-carboxylic acid) 是一种 D-氨基酸氧化酶 (DAAO) 抑制剂。
T3472	CGS 27023A	MMP	Proteases/Proteasome
	CGS 27023A 是一种非肽类强效口服活性基质溶解素抑制剂。
T1980	HA14-1	BCL	Apoptosis
	HA14-1 是一种 Bcl-2/Bcl-xL 拮抗剂，与 Bcl-2 上的特定口袋结合，IC50约为 9 μM。
T2639	LY2811376	Beta Amyloid; Beta-Secretase; BACE	Neuroscience
	LY2811376 是可口服的非肽段β-secretase (BACE1)抑制剂，IC50=239 nM-249 nM，能够降低 Aβ 蛋白的分泌，EC50=300 nM。
T24735	RP-23618
	RP-23618 is a non-peptidic antagonist of RANTES.
T24625	PF-184563 PF184563,PF 184563
	PF-184563 is an effective and selective non-peptidic V1a receptor antagonist.
T71091	Y2-Antagonist-2
	Y2-Antagonist-2 is a novel, selective, soluble non-peptidic NPY Y2 receptor antagonist with enhanced CNS exposure.
T70471	Cgs 26303
	Cgs 26303 is a potent non-peptidic inhibitor of neutral endopeptidase capable of protecting atrial natriuretic peptide from enzymatic degradation.
T71596	Bag-2
	Bag-2 is a Novel potent, non-peptidic bombesin receptor subtype-3 (BRS-3) agonist.
T71595	Bag-1
	Bag-1 is a novel potent, non-peptidic bombesin receptor subtype-3 (BRS-3) agonist.
T71997	CypD-IN-29
	CypD-IN-29 is a non-peptidic inhibitor of cyclophilin D as a neuroprotective agent in Aβ-induced mitochondrial dysfunction.
T16986	Tanomastat BAY 12-9566	MMP	Proteases/Proteasome
	Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively.
T40358	Ensitrelvir fumarate S-217622 fumarate
	Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor, targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM). It demonstrates non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2 virus.
T74939	HIV protease-IN-1
	HIVprotease-IN-1 (compound 1·succinate) 是一种有效的HIV 蛋白酶 (HIV protease) 非肽抑制剂，可用于艾滋病的研究。
T74097	THX-B
	THX-B为一高效非多肽类p75NTR（神经营养蛋白受体p75）拮抗剂，适用于糖尿病、肾病、神经退行性及炎症性疾病研究。
T61964	RXFP3/4 agonist 2	RXFP receptor	GPCR/G Protein
	RXFP3/4 agonist 2 是一种高效的非肽双 RXFP3/4 激动剂，诱导 RXFP3 和 β-arrestin-2 之间的相互作用，可用于研究代谢异常引起的疾病。

化合物

Cat.No: T7476

Synonym: 3-Methylpyrazole-5-carboxylic acid,5-甲基-1H-吡唑-3-羧酸

Target: Others

Cat.No: T3472

Target: MMP

Cat.No: T1980

Target: BCL

Cat.No: T2639

Target: Beta Amyloid, Beta-Secretase, BACE

Cat.No: T24735

Cat.No: T24625

Synonym: PF184563,PF 184563

Y2-Antagonist-2

Cat.No: T71091

Cat.No: T70471

Cat.No: T71596

Cat.No: T71595

Cat.No: T71997

Cat.No: T16986

Synonym: BAY 12-9566

Target: MMP

Ensitrelvir fumarate

Cat.No: T40358

Synonym: S-217622 fumarate

HIV protease-IN-1

Cat.No: T74939

Cat.No: T74097

RXFP3/4 agonist 2

Cat.No: T61964

Target: RXFP receptor

Cat. No.	Product Name	Target	Signaling Pathways
T10238	Aclacinomycin A hydrochloride 盐酸阿柔比星,Aclarubicin hydrochloride	Proteasome	Proteases/Proteasome; Ubiquitination
	Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II.

天然产物

Aclacinomycin A hydrochloride

Cat.No: T10238

Synonym: 盐酸阿柔比星,Aclarubicin hydrochloride

Target: Proteasome

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