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Cat. No.	Product Name	Target	Signaling Pathways
TP1310	Neurotensin	Neurotensin Receptor	GPCR/G Protein
	Neurotensin 是一种 13 个氨基酸的神经肽，参与调节促黄体激素和催乳素的释放，并与多巴胺能系统有显着的相互作用。它作为细胞有丝分裂原，作用于各种结肠直肠癌和胰腺癌。
T7617	Neurotensin(8-13) 神经降压素(8-13),Neurotensin(8-13)(3TFA)	Neurotensin Receptor	GPCR/G Protein
	Neurotensin(8-13) 是神经降压素的活性片段，可导致细胞表面 NT1 受体 (NTR1) 密度降低。
TP2309	NEUROTENSIN TFA (39379-15-2 free base) Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH TFA（55508-42-4 free base),NEUROTENSIN TFA,神经加压素	Others	Others
	Neurotensin TFA (39379-15-2 free base) 是一种内源性 13 个氨基酸的神经肽，具有显着的阿片类非依赖性镇痛作用。它在大脑中充当神经递质，在肠道中充当激素，也充当神经调节剂。由于它与多种神经递质系统如多巴胺能、血清素能、谷氨酸能、GABA 能和胆碱能系统。它具有作为人体代谢物、有丝分裂原、神经递质和创伤的作用。
T38807L	[Lys8, Lys9]-Neurotensin (8-13) acetate	Neurotensin Receptor	GPCR/G Protein
	[Lys8, Lys9]-Neurotensin (8-13) acetate 是一种神经降压素类似物，通过激活 G 蛋白偶联受体 NTS1 和 NTS2 发挥镇痛作用，hNTS1 和 hNTS2 受体的 Ki 值分别为 0.33 nM 和 0.95 nM。
T7617L	Neurotensin(8-13) 3TFA(60482-95-3(free base))	Neurotensin Receptor	GPCR/G Protein
	Neurotensin(8-13) 3TFA(60482-95-3(free base)) 是神经降压素 (NT) 片段，神经降压素 (8-13) 导致细胞表面 NT1 受体 (NTR1) 密度降低。
T40850	[D-Trp11]-Neurotensin [D-Trp11]-Neurotensin
	[D-Trp11]-Neurotensin is a compound that functions as a selective antagonist of Neurotensin (NT) in perfused rat hearts, while exhibiting full agonist properties in guinea pig atria and rat stomach strips. Additionally, this compound can inhibit hypotension induced by NT.
T38807	[Lys8, Lys9]-Neurotensin (8-13) JMV438,[Lys8, Lys9]-Neurotensin (8-13)
	[Lys8, Lys9]-Neurotensin (8-13) (JMV438) is a Neurotensin analog that elicits analgesic effects by activating the G protein-coupled receptors NTS1 and NTS2. The compound has K i values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively.
T33656	Neurotensin (1-6)
	Neurotensin (1-6) affects dopamine release from striatum.
TP2393	Neurotensin-related hexapeptide Lant-6
	Neurotensin-related hexapeptide exists in retinal ganglion cells and in their central projections in pigeons and may be utilized as a neuroactive substance by the central terminals of numerous retinal ganglion cells in birds.
T76572	Acetyl neurotensin (8-13)
	Acetyl neurotensin (8-13) 是神经降压素类似物，具有完全结合和药理活性。
TQ0086	AF38469 AF-38469	Neurotensin Receptor	GPCR/G Protein
	AF38469 是一种新型、特异性和可口服的Sortilin 抑制剂，IC50值为 330 nM。
T16860	SBI-553	Neurotensin Receptor	GPCR/G Protein
	SBI-553 是能透过血脑屏障的NTR1的别构抑制剂，EC50值为 0.34 μM。
T8657	KYP-2047	Others	Others
	KYP-2047 是一种非常有效的选择性脯氨酰寡肽酶 (POP) 抑制剂。
T9044	SORT-PGRN interaction inhibitor 1	Neurotensin Receptor	GPCR/G Protein
	SORT-PGRN interaction inhibitor 1 是一种 sortilin-progranulin 相互作用抑制剂，IC50为 2 μM。
T11861	LM11A-31 dihydrochloride	Others	Others
	LM11A-31 dihydrochloride 是一种具有高血脑屏障通透性的氨基酸衍生物，能阻断 p75 介导的细胞死亡。它是一种 p75NTR(神经营养蛋白受体 p75) 非肽调节剂，是口服有效的 proNGF 拮抗剂。它可以逆转中晚期的阿尔茨海默氏病小鼠模型中的胆碱能神经突营养不良。
T23386	SR 142948	Neurotensin Receptor	GPCR/G Protein
	SR 142948 是一种神经降压素 (NT) 受体拮抗剂。
T7615	Xenopsin 爪蟾肽,Xenopsin(2TFA)	Others	Others
	Xenopsin (Xenopsin(2TFA)) 是一种神经降压素样八肽，来自于非洲爪蟾皮肤，能够抑制胃泌素刺激的胃酸分泌。
TQ0075	ML314	Neurotensin Receptor	GPCR/G Protein
	ML314 是一种具有脑渗透性非肽 β-抑制素偏向神经降压素 NTR1 受体激动剂（EC50：1.9 μM），是一种用于甲基苯丙胺滥用的偏向神经降压素受体配体，抑制 NTR2 和 GPR35。
T28217	NTRC-844 NTRC 844,NTRC844	Neurotensin Receptor	GPCR/G Protein
	NTRC-844 是一种具有选择性的大鼠神经紧张素受体 2 型（NTS2）拮抗剂，在动物疼痛模型中显示出镇痛活性。
T7615L	Xenopsin 2TFA(51827-01-1(free base)	Others	Others
	Xenopsin 2TFA(51827-01-1(free base) 是一种以前从两栖动物皮肤中分离出来的神经降压素样八肽。
TP1116L	Kinetensin acetate(103131-69-7 free base) Kinetensin (human) acetate	Neurotensin Receptor	GPCR/G Protein
	Kinetensin acetate(103131-69-7 free base) 是从经胃蛋白酶处理的人血浆中分离出来的。它是一种神经降压素样肽。
TP1085L	Neuromedin N acetate(92169-45-4 free base) Neuromedin N (rat, mouse, porcine, canine) acetate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Neuromedin N acetate(92169-45-4 free base) 是一种神经肽，其衍生自与神经降压素相同的前体多肽，具有相似但略有不同的表达和作用。Neuromedin N 是多巴胺 D2 受体激动剂与大鼠新纹状体膜结合的有效调节剂。
TP2209L	Xenin 8 acetate Xenin 8 acetate (117442-28-1 Free base)	IGF-1R	Tyrosine Kinase/Adaptors
	Xenin 8 acetate 是神经降压素/异视素家族中 Xenin 的生物活性片段。 Xenin 8 acetate 增强精氨酸诱导的胰岛素释放（40%）并增强胰高血糖素对精氨酸（60%）和卡巴胆碱（50%）的反应。
T37529	TC NTR1 17
	Non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50 <15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35. Hershberger et al (2014) Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg.Med.Chem.Lett. 24 262 PMID:24332089
T16034	Meclinertant SR 48692	Others	Others
	Meclinertant is an effective, selective, nonpeptide, and orally active neurotensin receptor 1 (NTS1) antagonist. Meclinertant competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization (pA2 : 8.13), in human colon carcinoma (HT-29) cell
T16358	NTRC-824	Others	Others
	NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM). NTRC-824 is an effective, selective, and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist (IC50: 38 nM and a Ki : 202 nM).
TP2462	Magaratensin Asp-lys-arg-pro-tyr-ile-leu-his-glu
	Magaratensin is a neurotensin-related peptide related to the skin of Rana margarate.
T70271	PD-149163
	PD-149163 is a selective, brain penetrating Neurotensin NTR1 receptor agonist. Neurotensin agonists block the pre-pulse inhibition deficits produced by a 5-HT2A and an α1 agonist. As a result, PD-149163 shows pro-cognitive, anti-psychotic and anxiolytic effects.
T75711	Contulakin G
	Contulakin G为O-糖基化无脊椎动物神经紧张素，作为较弱的神经紧张素受体(neurotensin receptor)激动剂，并具有有效的镇痛作用。
T75868	JMV 449 acetate
	JMV 449 acetate 是一种有效的神经降压素受体 (neurotensin receptor) 激动剂。JMV 449 acetate 显示抑制125I-neurotensin 与新生小鼠脑结合的 IC50为 0.15 nM，对收缩豚鼠回肠的 EC50为 1.9 nM。JMV 449 acetate 对小鼠具有高效、持久的降温和缓解疼痛作用。
T28845	SR142948A HCl SR142948A,SR 142948A,SR-142948A,SR142948A hydrochloride
	SR 142948A is a non-peptide antagonist of neurotensin receptor. SR 142948A affects the expression of c-Fos and has properties of antipsychotic agent. SR 142948A blocks hypothermia and analgesia induced by neurotensin. It blocks the increase in the concent
T72410	Sortilin antagonist 1
	Sortilin antagonist 1 是一种 sortilin 拮抗剂，抑制神经紧张素 (NTS) 与 Sortilin 结合的 IC50值为 20 nM。NTS 是 sortilin 配体。Sortilin antagonist 1 可用于神经疾病的研究。
T32700	Levocabastine Livostin,Bilina
	Levocarbastine is a second-generation H1 receptor antagonist for allergic conjunctivitis. It also acts as a potent selective antagonist for the neurotensin receptor NTS2 and is the first drug to be used to characterize different neurotensin subtypes.
TP2209	Xenin-8	Others	Others
	neurotensin-like peptide that modulate pancreatic insulin and glucagon secretion/effects
T24279	L 156903 L-156903,L156903
	L 156903 is a bioactive chemical. It also inhibits the binding of neurotensin to brain tissue.
TP1116	Kinetensin Kinetensin (human)
	Kinetensin is a neurotensin-like peptide.
TP1085	Neuromedin N Neuromedin N (rat, mouse, porcine, canine)
	Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.
T13530	AF40431	Others	Others
	AF40431 is the first reported small-molecule ligand of sortilin (IC50: 4.4 µM; Kd: 0.7 µM). AF40431 is bound in the neurotensin-binding site of sortilin.
TP2012	JMV 449
	Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analg
TP1482	Xenopsin TFA (51827-01-1 free base) Xenopsin TFA
	Xenopsin TFA is a neurotensin-like octapeptide derived from the skin of xenopus xenopus.Xenopsin TFA is an inhibitor of tetrachloroside to stimulate gastric acid secretion.
T78954	hNTS1R agonist-1	Neurotensin Receptor	GPCR/G Protein
	hNTS1R agonist-1 (Compound 10)为能穿透血脑屏障的hNTS1R全激动剂（Ki：6.9 nM）。它能提升帕金森病（PD）模型小鼠的运动能力及记忆。作为一种Neurotensin(8-13)类似物，hNTS1R agonist-1同时具有神经保护作用。
T82647	Cyanine5 NHS ester bromide
	Cyanine5 NHS ester bromide 是用于标记肽、蛋白质和寡核苷酸氨基的活性染料。作为菁染料，该化合物特别适用于通过精氨酸残基对神经紧张素 (8-13) 进行荧光标记。
T80765	Xenopsin TFA
	Xenopsin TFA是一种神经降压素样八肽，源自非洲爪蟾皮肤。该化合物能够抑制胃泌素刺激的胃酸分泌。
T80766	Xenin-8 TFA
	Xenin-8 TFA为Xenin的C端八肽段，同时是其生物活性片段。该化合物隶属于神经降压素/xenopsin家族多肽中。它能激发基础胰岛素的分泌并剂量依赖性地加强胰岛素对葡萄糖反应(EC50=0.16 nM)。
T70039	BIM-46174
	BIM-46174 is a New Inhibitor of the Heterotrimeric Gα/Gβγ Protein Complex. BIM-46174 acts as a selective inhibitor of heterotrimeric G-protein complex. BIM-46174 prevents the heterotrimeric G-protein signaling linked to several GPCRs mediating (a) cyclic AMP generation (Gαs), (b) calcium release (Gαq), and (c) cancer cell invasion by Wnt-2 frizzled receptors and high-affinity neurotensin receptors (Gαo/i and Gαq). BIM-46174 inhibits the growth of a large panel of human cancer cell lines, includ...
T73677	SR 142948 dihydrochloride
	SR 142948 dihydrochloride是一种口服活性高、选择性强的非肽类神经降压素受体(NT)拮抗剂，其在h-NTR1-CHO细胞、HT-29细胞和成年大鼠脑中IC50分别为1.19 nM、0.32 nM、3.96 nM。在HT-29细胞中，该化合物能够有效拮抗NT诱导的肌醇单磷酸盐形成，IC50为3.9 nM。此外，SR 142948 dihydrochloride在体内能够阻断NT诱导的体温下降、镇痛和转向行为，且具有良好的血脑屏障通透性，适用于精神疾病研究。

化合物

Cat.No: TP1310

Target: Neurotensin Receptor

Neurotensin(8-13)

Cat.No: T7617

Synonym: 神经降压素(8-13),Neurotensin(8-13)(3TFA)

Target: Neurotensin Receptor

NEUROTENSIN TFA (39379-15-2 free base)

Cat.No: TP2309

Synonym: Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH TFA（55508-42-4 free base),NEUROTENSIN TFA,神经加压素

Target: Others

[Lys8, Lys9]-Neurotensin (8-13) acetate

Cat.No: T38807L

Target: Neurotensin Receptor

Neurotensin(8-13) 3TFA(60482-95-3(free base))

Cat.No: T7617L

Target: Neurotensin Receptor

[D-Trp11]-Neurotensin

Cat.No: T40850

Synonym: [D-Trp11]-Neurotensin

[Lys8, Lys9]-Neurotensin (8-13)

Cat.No: T38807

Synonym: JMV438,[Lys8, Lys9]-Neurotensin (8-13)

Neurotensin (1-6)

Cat.No: T33656

Neurotensin-related hexapeptide

Cat.No: TP2393

Synonym: Lant-6

Acetyl neurotensin (8-13)

Cat.No: T76572

Cat.No: TQ0086

Synonym: AF-38469

Target: Neurotensin Receptor

Cat.No: T16860

Target: Neurotensin Receptor

Cat.No: T8657

Target: Others

SORT-PGRN interaction inhibitor 1

Cat.No: T9044

Target: Neurotensin Receptor

LM11A-31 dihydrochloride

Cat.No: T11861

Target: Others

Cat.No: T23386

Target: Neurotensin Receptor

Cat.No: T7615

Synonym: 爪蟾肽,Xenopsin(2TFA)

Target: Others

Cat.No: TQ0075

Target: Neurotensin Receptor

Cat.No: T28217

Synonym: NTRC 844,NTRC844

Target: Neurotensin Receptor

Xenopsin 2TFA(51827-01-1(free base)

Cat.No: T7615L

Target: Others

Kinetensin acetate(103131-69-7 free base)

Cat.No: TP1116L

Synonym: Kinetensin (human) acetate

Target: Neurotensin Receptor

Neuromedin N acetate(92169-45-4 free base)

Cat.No: TP1085L

Synonym: Neuromedin N (rat, mouse, porcine, canine) acetate

Target: Dopamine Receptor

Xenin 8 acetate

Cat.No: TP2209L

Synonym: Xenin 8 acetate (117442-28-1 Free base)

Target: IGF-1R

Cat.No: T37529

Cat.No: T16034

Synonym: SR 48692

Target: Others

Cat.No: T16358

Target: Others

Cat.No: TP2462

Synonym: Asp-lys-arg-pro-tyr-ile-leu-his-glu

Cat.No: T70271

Cat.No: T75711

JMV 449 acetate

Cat.No: T75868

Cat.No: T28845

Synonym: SR142948A,SR 142948A,SR-142948A,SR142948A hydrochloride

Sortilin antagonist 1

Cat.No: T72410

Cat.No: T32700

Synonym: Livostin,Bilina

Cat.No: TP2209

Target: Others

Cat.No: T24279

Synonym: L-156903,L156903

Cat.No: TP1116

Synonym: Kinetensin (human)

Cat.No: TP1085

Synonym: Neuromedin N (rat, mouse, porcine, canine)

Cat.No: T13530

Target: Others

Cat.No: TP2012

Xenopsin TFA (51827-01-1 free base)

Cat.No: TP1482

Synonym: Xenopsin TFA

hNTS1R agonist-1

Cat.No: T78954

Target: Neurotensin Receptor

Cyanine5 NHS ester bromide

Cat.No: T82647

Cat.No: T80765

Cat.No: T80766

Cat.No: T70039

SR 142948 dihydrochloride

Cat.No: T73677

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