Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21700 |
NOS-IN-1
2-Imino-4-methylpiperidine (acetate) |
NOS | Immunology/Inflammation |
NOS-IN-1 (2-Imino-4-methylpiperidine acetate) 是有效的、具有口服活性的一氧化氮合酶 (NOS) 的抑制剂。NOS-IN-1抑制人 iNOS (hiNOS),hnNOS 和 heNOS 的 IC50 分别为 0.1 μM,0.2 μM 和1.1 μM。 | |||
T37696 |
NOS1-IN-1
nNOS Inhibitor I |
NOS | Immunology/Inflammation |
NOS1-IN-1(nNOS Inhibitor I) 是一种强效、选择性和细胞渗透性 nNOS 抑制剂(Ki:120 nM)。NOS1-IN-1 对 eNOS 的 Ki 值为 39 μM,对 iNOS 的 Ki 值为 325 μM。 | |||
T0825 |
Ebselen
SPI-1005,PZ-51,依布硒,CCG-39161 |
Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。 | |||
T61426 | NOS-IN-2 | ||
NOS-IN-2 (Compound 4i) 是一个强效的、选择性的由 imidamide 衍生的NOS 抑制剂,对iNOS 的IC50值为20 μM。NOS-IN-2 不抑制 eNOS,几乎没有毒性,可用于研究炎症性疾病。 | |||
T78229 |
Aminoguanidine hemisulfate
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Aminoguanidine hemisulfate 作为NOS及ROS的抑制剂,能够在体外有效清除ANE诱导的ROS生成,因此它被广泛应用于癌症研究领域。 | |||
T73353 | NOS-IN-3 | ||
NOS-IN-3 是一个强效的、选择性的由 imidamide 衍生的NOS 抑制剂,对iNOS 的IC50值为20 µM。 NOS-IN-3 不抑制eNOS,几乎没有毒性,可用于研究治疗可诱导亚型涉及的疾病,如感染性休克。 | |||
T82251 |
GW274150 dihydrochloride
|
NO Synthase | Immunology/Inflammation |
GW274150 (dihydrochloride) 是高效、选择性的 NADPH 依赖型人诱导型一氧化氮合成酶 (iNOS) (Kd=40 nM) 抑制剂,具有口服活性,同时对大鼠 (iNOS) 也有效。相较于人和大鼠的内皮一氧化氮合酶 (eNOS) 及神经元一氧化氮合酶 (nNOS),其效力显著较低。GW274150 (dihydrochloride) 在急性肺损伤炎症模型中具有保护作用。 | |||
T37270 |
9(E),11(E)-12-nitro Conjugated Linoleic Acid
|
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9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma. 1.Woodcock, S.R., Salvato... | |||
T36777 |
Thrombin Receptor Agonist Peptide (trifluoroacetate salt)
|
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Thrombin receptor agonist peptide (TRAP-14) is a 14-amino acid peptide agonist of the α-thrombin receptor. It induces aggregation of washed platelets as well as platelets in citrated and hirudin plasma. TRAP-14 (100 μM) increases the cytosolic calcium concentration in isolated guinea pig pulmonary smooth muscle cells 5-fold over baseline. It increases pulmonary arterial pressure in isolated guinea pig lung when used at a concentration of 1 μM, which is comparable to the effect induced by 10 nM α... | |||
T37235 |
(±)16(17)-EpDPA
(±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA |
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahex... | |||
T75339 | Methylene blue hydrate | ||
亚甲蓝(Basic Blue 9)水合物,作为鸟苷酸环化酶(sGC)、单胺氧化酶A(MAO-A)及NO合酶(NOS)的抑制剂,常用于医疗作为血管加压剂及染料。该化合物通过影响一氧化氮合成酶/鸟苷酸环化酶信号通路,能够减少脉冲前抑制,同时作为一种氧化还原循环化合物,具有穿透血脑屏障的能力,并作为Tau蛋白聚集的抑制剂,有助于缓解脑水肿、减轻小胶质细胞活化和神经炎症。 |