Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13281 |
Valopicitabine
NM283 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic HCV infection. | |||
T29094 |
Valopicitabine dihydrochloride
NMC283,Valopicitabine HCl,NM-283,Valopicitabine,NMC-283,Valopicitabine dihydrochloride, Valopicitabine HCl,NM283 |
||
Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection. | |||
T13477 |
β-Glucuronidase-IN-1
|
Antibacterial | Microbiology/Virology |
β-Glucuronidase-IN-1 是一种 E. coli β-葡萄糖醛酸酶 (β-glucuronidase) 抑制剂,对 E. coli β-葡萄糖醛酸酶的 IC50 和 Ki 值分别为 283 nM 和 164 nM,具有强效性,选择性,非竞争性和具有口服活性。 | |||
T22272 |
Lifirafenib
BGB-283,Beigene-283 |
EGFR; Raf | Angiogenesis; JAK/STAT signaling; MAPK; Tyrosine Kinase/Adaptors |
Lifirafenib (Beigene-283) 是新型高效的Raf 激酶和EGFR 抑制剂,对重组BRafV600E 和EGFR 的IC50值分别为 23 和 29 nM。 | |||
T12997 |
SR-318
|
p38 MAPK; TNF | Apoptosis; MAPK |
SR-318 是p38 MAPK 的选择性抑制剂,对 p38α,p38β 和 p38α/β 的IC50分别为 5 nM,32 nM 和 6.11 μM。它有效抑制全血中TNF-α的释放,IC50为 283 nM。它显示出抗癌和抗炎活性。 | |||
T15767 |
LLY-283
|
Histone Methyltransferase | Chromatin/Epigenetic |
LLY-283 是一种有效的,选择性的,可口服的蛋白精氨酸甲基转移酶 5 (PRMT5) 抑制剂,对 PRMT5:MEP50 复合物的作用很强,IC50 和 Kd 值分别为 22 nM 和 6 nM,具有抗肿瘤活性。 | |||
T13242 |
UbcH5c-IN-1
|
Others | Others |
UbcH5c-IN-1 is a selective small-molecule Ubiquitin-conjugating enzyme UbcH5c inhibitor (Kd: 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85). | |||
T63817 |
Axl-IN-5
|
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Axl-IN-5 (compound 1) 是 AXL 抑制剂 (IC50: 283 nM),表现出抗癌活性。 | |||
T79822 |
DGKα-IN-3
|
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DGKα-IN-3 作为DGKα抑制剂,具有283 nM的IC50。该化合物能够通过提升T细胞的增殖及功能,显著增强抗PD-1治疗的抗肿瘤效果。因此,DGKα-IN-2在肿瘤和免疫学领域研究中显示出了潜在的应用价值。 | |||
T36427 |
PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)
|
PACAP | GPCR/G Protein |
Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors on SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 24.5, 106, and 105 nM, respectively) and inhibits cAMP accumulation induced by PACAP (1-38) (Kis = 457, 102, and 283 nM, respectively, in SH-SY5Y, ... | |||
T35854 |
9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
|
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9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-co... | |||
T15828 |
L 888607
|
Others | Others |
L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM). |