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Search Results for " nfat "

17

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1015	NFAT Inhibitor VIVIT peptide	Others	Others
	NFAT Inhibitor (VIVIT peptide) 是NFAT 的细胞渗透性肽抑制剂，能够选择性抑制钙调磷酸酶介导的NFAT 脱磷酸作用。
T50103	NFAT Inhibitor-2	Others	Others
	NFAT Inhibitor-2 是一种化学合成中的砌块。
T12218	NFAT Transcription Factor Regulator-1	IL Receptor	Immunology/Inflammation
	NFAT Transcription Factor Regulator-1 是 IL-2 合成的抑制剂，IC50 值为182 nM。
TP1978L	NFAT inhibitor, Cell Permeable aceate	Others	Others
	NFAT inhibitor, Cell Permeable aceate 是一种细胞可渗透的活化 T 细胞核因子 (NFAT) 抑制剂。可用于足细胞和糖尿病肾病的研究。
TP1978	11R-VIVIT NFAT inhibitor, Cell Permeable
	NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse
T125647	Antibiotic NFAT 133
	Antibiotic NFAT 133 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125647，CAS号为 165133-85-7。
T27612	INI-43 INI 43,INI43	Others	Others
	INI-43 是Nuclear Import-43 的抑制剂，通过靶向 Kpnβ1 对各种宫颈和食管癌细胞系显示出显着的细胞毒性作用，并干扰 Kpnβ1 和已知的 Kpnβ1 cargo 蛋白、NFAT、NFκB、AP-1和NFY 的核定位。
T21807	INCA-6 Triptycene-1,4-quinone	Others	Others
	INCA-6 (Triptycene-1,4-quinone) 是细胞渗透性的 NFAT 抑制剂。INCA-6 通过特异性阻断 NFAT 底物靶向钙调神经磷酸酶位点，有效抑制calcineurin (CN)-NFAT 信号传导。
T68594	NFAT:AP-1 inhibitor-10
	NFAT:AP-1 inhibitor-10 is a novel inhibitor of the NFAT:AP-1:DNA interaction on the ARRE-2 element, binding to DNA in a sequence-selective manner and inhibiting the transcription of the Il2 gene and several other cyclosporin A-sensitive cytokine genes important for the effector immune response.
T61531	NFATc1-IN-1	RANKL/RANK	NF-κB
	NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuclear translocation of NFATc1. Due to its remarkable properties, NFATc1-IN-1 holds significant potential for advancing research related to osteoclastic diseases [1].
T23186	ProINDY Pro-indy	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	ProINDY(Pro-indy) 是一种有效的 DYRK 抑制剂，可激活激活 NFAT ，可用于研究唐氏综合征。
T35885	KRM-III	Others	Others
	KRM-III 是一种具有口服活性的 T 细胞抗原受体 (TCR) 抑制剂，具有抗炎活性，可有效抑制 TCR 和肉豆蔻酸乙酸酯/佛波霉素/离子霉素诱导的 NFAT 核因子活化和 T 细胞增殖，IC50 约为 5 μM。
T5339	YZ129
	YZ129 是一种抗胶质母细胞瘤的HSP90-磷酸酶-NFAT 通路的抑制剂，直接与热休克蛋白 (HSP90)结合，对NFAT 核易位的IC50值为820 nM。YZ129 在 G2/M 期诱导GBM 细胞周期阻滞，促进细胞凋亡，抑制肿瘤细胞增值和迁移。
T69754	BTP1
	BTP1 is an inhibitor of NFAT activation and T-cell cytokine production. BTP1 potently inhibits SOCE in many cells with considerable selectivity over voltage-gated Ca2+ entry.
T35892	Q134R Q134R
	Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer’s disease (AD) and aging-related disorders research[1]. Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo...
T71295	SOR-C13
	SOR-C13 is an inhibitor of transient receptor potential cation channel vanilloid family member 6 (TRPV6, CaT1 or CATL) with potential antineoplastic activity. TRPV6 calcium channel inhibitor SOR-C13 binds to TRPV6 and prevents the influx of calcium ions into TRPV6-expressing tumor cells. This inhibits the activation of nuclear factor of activated T-cell (NFAT) transcription complex which may result in an inhibition of calcium-dependent cancer cell proliferation and an induction of apoptosis in t...
TP1978L1	11R-VIVIT TFA (592517-80-1 Free base)
	11R-VIVIT TFA (592517-80-1 Free base) 是一种 NFAT 抑制剂。 11R-VIVIT TFA 抑制 LPS 或 LPS 加 IFN-γ 诱导的骨髓源性巨噬细胞 (BMDM) 分泌 IL-12 p40、IL-12 p70、IL-23 和 TNF。 11R-VIVIT TFA 减弱 LPS 刺激的 BMDM 中 NO 的产生和 Nos2 mRNA 的表达。 11R-VIVIT TFA 改善结肠炎小鼠模型的症状。 11R-VIVIT TFA 表现出免疫抑制作用并提高小鼠移植物的存活率。 11R-VIVIT TFA 具有细胞渗透性。

化合物

NFAT Inhibitor

Cat.No: TP1015

Synonym: VIVIT peptide

Target: Others

NFAT Inhibitor-2

Cat.No: T50103

Target: Others

NFAT Transcription Factor Regulator-1

Cat.No: T12218

Target: IL Receptor

NFAT inhibitor, Cell Permeable aceate

Cat.No: TP1978L

Target: Others

Cat.No: TP1978

Synonym: NFAT inhibitor, Cell Permeable

Antibiotic NFAT 133

Cat.No: T125647

Cat.No: T27612

Synonym: INI 43,INI43

Target: Others

Cat.No: T21807

Synonym: Triptycene-1,4-quinone

Target: Others

NFAT:AP-1 inhibitor-10

Cat.No: T68594

Cat.No: T61531

Target: RANKL/RANK

Cat.No: T23186

Synonym: Pro-indy

Target: DYRK

Cat.No: T35885

Target: Others

Cat.No: T5339

Cat.No: T69754

Cat.No: T35892

Synonym: Q134R

Cat.No: T71295

11R-VIVIT TFA (592517-80-1 Free base)

Cat.No: TP1978L1

Cat. No.	Product Name	Target	Signaling Pathways
TL0013	Heraclenin 独活内酯	Anti-infection; Immunology/Inflammation related	Immunology/Inflammation; Microbiology/Virology
	Heraclenin 是一种天然呋喃香豆素。它浓度依赖性的靶向激活的 T 细胞核因子 (NFAT) ，抑制人原代 T 细胞中 T 细胞受体介导的增殖。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
T38285	C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))	Others	Others
	C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))是成熟髓鞘中主要的硫酸盐类化合物。C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) 在大鼠小脑中发现活跃的髓发生鞘化反应时积累率高于C24 3'-sulfo 半乳糖甘油酰胺。C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))与C 型凝集素和免疫球蛋白样受体相互作用使对LMIR5的亲和力高。C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))诱导嗜碱细胞产生MCP-1，可通过增加LMIR5激活NFAT，但不能诱导肥大细胞。C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))在体外与CD1d 结合，并增加游离小鼠脾细胞的增殖。
TN2249	(+)-Syringaresinol	Sirtuin; Antifection	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.

天然产物

Cat.No: TL0013

Synonym: 独活内酯

Target: Anti-infection, Immunology/Inflammation related

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))

Cat.No: T38285

Synonym: C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))

Target: Others

(+)-Syringaresinol

Cat.No: TN2249

Target: Sirtuin, Antifection

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