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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T74841	NF-κB-IN-9
	NF-κB-IN-9 是一种靶向核因子 NF-κB 的声敏剂 (λex/λem=489/628 nm)。NF-κB-IN-9 由于分子中有两个白藜芦醇单元，而对 NF-κB 信号表现出强烈的抑制作用。NF-κB-IN-9 具有抗肿瘤活性，并对癌细胞表现出显着的声细胞毒性。NF-κB-IN-9 在小鼠移植模型中具有生物安全性。
T15017	CU-T12-9	TLR	Immunology/Inflammation
	CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。
T39415	ACAT-IN-9
	ACAT-IN-9, acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By doing so, it effectively suppresses NF-κB mediated transcription.
T27033	CKD-712 CKD 712,CKD712
	CKD-712 is a nuclear factor NF-kappa B inhibitor. CKD-712 suppressed MMP-9, but not MMP-2 and other NF-κB-regulated proteins involved in cancer metastasis such as VEGF. CKD-712 induced cell cycle arrest at G2M phase by suppressing cyclin A, cyclin B and C
T72102	Glucocorticoid receptor modulator 1
	Glucocorticoid receptor modulator1 是一种高效且具有口服活性的 NF-κB 和 AP-1抑制剂，IC50分别为 9 nM 和 130 nM。Glucocorticoid receptor modulator1 可有效降低炎症因子 IL-6、IL-1β、TNF-α 的表达，可缓解小鼠皮炎。
T35701	FSL-1 TFA
	FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1]. FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells[2]. FSL-1 significantly reduces HSV-2 replication in human vaginal epithelial cells (EC)[1].FSL-1 induces significant resistance to experimental genital HSV-2 infection through elaboration of a specific cytokine response profile[1].FSL-1 (50 ng/mL, 24 hours) induce...
T29060	UNBS-1450 UNBS 1450,UBS1450,UBS-1450,UBS 1450
	UNBS-1450 is a sodium channel antagonist. UNBS-1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin, it is effective against various cancer cell types with an excellent differential toxicity. At low nanomolar concentrations, UNBS-1450 induce

化合物

Synonym: CKD 712,CKD712

Target:

Glucocorticoid receptor modulator 1

Synonym: UNBS 1450,UBS1450,UBS-1450,UBS 1450

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T3729	Ethyl gallate Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯	MMP; NF-κB; Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。
T6S1699	Shogaol [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol	Lipoxygenase; Autophagy	Autophagy; Metabolism
	6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物，具有抗癌、抗炎和抗氧化的多种生物活性。