9
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5374 |
NAcM-OPT
|
E1/E2/E3 Enzyme; NEDD8 | Metabolism; Ubiquitination |
NAcM-OPT 是口服活性、有效的 cullin neddylation 1 抑制剂,可以抑制 DCN1-UBE2M 相互作用。 | |||
T8816 |
NAE-IN-M22
NEDD8 inhibitor M22 |
Apoptosis; E1/E2/E3 Enzyme | Apoptosis; Ubiquitination |
NAE-IN-M22 (NEDD8 inhibitor M22) 是一种选择性可逆的 NEDD8 激活酶抑制剂。 它抑制多种癌细胞系并诱导 A549 细胞凋亡,还可以在体内抑制肿瘤生长。 | |||
T6332 |
Pevonedistat
MLN4924 |
E1/E2/E3 Enzyme; NEDD8 | Metabolism; Ubiquitination |
Pevonedistat (MLN4924) 是一种 NEDD8 活化酶 (NAE) 抑制剂 (IC50=4.7 nM),具有有效性和选择性。Pevonedistat 可以用于骨髓增生异常综合症 (MDS)的治疗,也具有抗肿瘤活性。 | |||
T13090 |
TAS4464 hydrochloride
|
E1/E2/E3 Enzyme; NEDD8 | Metabolism; Ubiquitination |
TAS4464 hydrochloride 是高效的、选择性的 NEDD8 活化酶 (NAE)抑制剂,其 IC50=0.955 nM。 | |||
T13412 |
ZM223
ZM-223 |
E1/E2/E3 Enzyme | Ubiquitination |
ZM223 是 NEDD8 活化酶 (NAE) 的抑制剂。 | |||
T16102 |
ML-792
|
E1/E2/E3 Enzyme | Ubiquitination |
ML-792 是特异性的小泛素样修饰物活化酶抑制剂。ML-792选择性抑制SAE/SUMO1和SAE/SUMO2,IC50分别为 3 和 11 nM,对 NAE/NEDD8 和 UAE/ubiquitin 抑制作用微弱,IC50分别为 32 μM 和 >100 μM。 | |||
T16117 |
Pevonedistat hydrochloride
MLN4924 hydrochloride |
Others | Others |
Pevonedistat hydrochloride is an effective and selective inhibitor of NEDD8-activating enzyme (IC50: 4.7 nM). | |||
T13412L |
ZM223 hydrochloride (2031177-48-5 free base)
ZM223 hydrochloride |
Serine Protease | Proteases/Proteasome |
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity. | |||
T13090L | TAS4464 | E1/E2/E3 Enzyme | Ubiquitination |
TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM). |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1570 |
Deoxyvasicinone
脱氧鸭嘴花酮碱 |
Others | Others |
Deoxyvasicinone derivatives can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme. |