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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8816	NAE-IN-M22 NEDD8 inhibitor M22	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	NAE-IN-M22 (NEDD8 inhibitor M22) 是一种选择性可逆的 NEDD8 激活酶抑制剂。它抑制多种癌细胞系并诱导 A549 细胞凋亡，还可以在体内抑制肿瘤生长。
T6332	Pevonedistat MLN4924	E1/E2/E3 Enzyme; NEDD8	Metabolism; Ubiquitination
	Pevonedistat (MLN4924) 是一种 NEDD8 活化酶 (NAE) 抑制剂 (IC50=4.7 nM)，具有有效性和选择性。Pevonedistat 可以用于骨髓增生异常综合症 (MDS)的治疗，也具有抗肿瘤活性。
T13090	TAS4464 hydrochloride	E1/E2/E3 Enzyme; NEDD8	Metabolism; Ubiquitination
	TAS4464 hydrochloride 是高效的、选择性的 NEDD8 活化酶 (NAE)抑制剂，其 IC50=0.955 nM。
T5374	NAcM-OPT	E1/E2/E3 Enzyme; NEDD8	Metabolism; Ubiquitination
	NAcM-OPT 是口服活性、有效的 cullin neddylation 1 抑制剂，可以抑制 DCN1-UBE2M 相互作用。
T13412	ZM223 ZM-223	E1/E2/E3 Enzyme	Ubiquitination
	ZM223 是 NEDD8 活化酶 (NAE) 的抑制剂。
T16102	ML-792	E1/E2/E3 Enzyme	Ubiquitination
	ML-792 是特异性的小泛素样修饰物活化酶抑制剂。ML-792选择性抑制SAE/SUMO1和SAE/SUMO2，IC50分别为 3 和 11 nM，对 NAE/NEDD8 和 UAE/ubiquitin 抑制作用微弱，IC50分别为 32 μM 和 >100 μM。
T13412L	ZM223 hydrochloride (2031177-48-5 free base) ZM223 hydrochloride	Serine Protease	Proteases/Proteasome
	ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
T16117	Pevonedistat hydrochloride MLN4924 hydrochloride	Others	Others
	Pevonedistat hydrochloride is an effective and selective inhibitor of NEDD8-activating enzyme (IC50: 4.7 nM).
T63800	ZM223 hydrochloride
	ZM223 hydrochloride 是有效的、非共价的、口服具有活力的 NEDD8 活化酶 (NAE) 抑制剂。
T13090L	TAS4464	E1/E2/E3 Enzyme	Ubiquitination
	TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).

化合物

NAE-IN-M22

Cat.No: T8816

Synonym: NEDD8 inhibitor M22

Target: Apoptosis, E1/E2/E3 Enzyme

Pevonedistat

Cat.No: T6332

Synonym: MLN4924

Target: E1/E2/E3 Enzyme, NEDD8

TAS4464 hydrochloride

Cat.No: T13090

Synonym:

Target: E1/E2/E3 Enzyme, NEDD8

NAcM-OPT

Cat.No: T5374

Synonym:

Target: E1/E2/E3 Enzyme, NEDD8

ZM223

Cat.No: T13412

Synonym: ZM-223

Target: E1/E2/E3 Enzyme

ML-792

Cat.No: T16102

Synonym:

Target: E1/E2/E3 Enzyme

ZM223 hydrochloride (2031177-48-5 free base)

Cat.No: T13412L

Synonym: ZM223 hydrochloride

Target: Serine Protease

Pevonedistat hydrochloride

Cat.No: T16117

Synonym: MLN4924 hydrochloride

Target: E1/E2/E3 Enzyme

Cat. No.	Product Name	Target	Signaling Pathways
TN1570	Deoxyvasicinone 脱氧鸭嘴花酮碱	Others	Others
	Deoxyvasicinone derivatives can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme.