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Cat. No.	Product Name	Target	Signaling Pathways
T8816	NAE-IN-M22 NEDD8 inhibitor M22	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	NAE-IN-M22 (NEDD8 inhibitor M22) 是一种选择性可逆的 NEDD8 激活酶抑制剂。它抑制多种癌细胞系并诱导 A549 细胞凋亡，还可以在体内抑制肿瘤生长。
T6332	Pevonedistat MLN4924	E1/E2/E3 Enzyme; NEDD8	Metabolism; Ubiquitination
	Pevonedistat (MLN4924) 是一种 NEDD8 活化酶 (NAE) 抑制剂 (IC50=4.7 nM)，具有有效性和选择性。Pevonedistat 可以用于骨髓增生异常综合症 (MDS)的治疗，也具有抗肿瘤活性。
T13090	TAS4464 hydrochloride	E1/E2/E3 Enzyme; NEDD8	Metabolism; Ubiquitination
	TAS4464 hydrochloride 是高效的、选择性的 NEDD8 活化酶 (NAE)抑制剂，其 IC50=0.955 nM。
T5374	NAcM-OPT	E1/E2/E3 Enzyme; NEDD8	Metabolism; Ubiquitination
	NAcM-OPT 是口服活性、有效的 cullin neddylation 1 抑制剂，可以抑制 DCN1-UBE2M 相互作用。
T16335	Nonaethylene glycol monododecyl ether Nonaoxyethylene monododecyl ether,Polidocanol,聚醚醇	Others	Others
	Nonaethylene glycol monododecyl ether (Polidocanol) 是一种非离子表面活性剂和聚乙二醇清洁剂，可用于蛋白质分离和纯化，以及用于形成初始聚结的 O/W 乳剂液滴。
T124493	Senaetnine
	Senaetnine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124493。
T76249L	RNAENFDRF TFA
	RNAENFDRF (βIIPKC624-632) TFA 与细胞渗透性肽 TAT47-57 结合，可用于形成抑制性肽 SAMβA。SAMβA 是一种 Mfn1-βIIPKC 结合选择性拮抗剂。SAMβA 是 mitofusin 1-βIIPKC 关联的选择性抑制剂，可改善大鼠心力衰竭。
T33578	Naepaine hydrochloride
	Naepaine hydrochloride is a biochemical.
T25847	NAEPA
	NAEPA, an LPA mimetic, is a selective agonist of the lysophosphatidic acid-1 (LPA1) receptor.
T16336	Nonaethylene glycol monomethyl ether	Others	Others
	Nonaethylene glycol monomethyl ether, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].
T76249	RNAENFDRF
	RNAENFDRF (βIIPKC624-632) 与细胞渗透性肽 TAT47-57 结合，可用于形成抑制性肽 SAMβA。SAMβA 是一种 Mfn1-βIIPKC 结合选择性拮抗剂。SAMβA 是 mitofusin 1-βIIPKC 关联的选择性抑制剂，可改善大鼠心力衰竭。
T16337	Nonaethylene glycol	Others	Others
	Nonaethylene glycol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T126132	Tabernaecorymbosine A
	Tabernaecorymbosine A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126132。
T13412	ZM223 ZM-223	E1/E2/E3 Enzyme	Ubiquitination
	ZM223 是 NEDD8 活化酶 (NAE) 的抑制剂。
T16102	ML-792	E1/E2/E3 Enzyme	Ubiquitination
	ML-792 是特异性的小泛素样修饰物活化酶抑制剂。ML-792选择性抑制SAE/SUMO1和SAE/SUMO2，IC50分别为 3 和 11 nM，对 NAE/NEDD8 和 UAE/ubiquitin 抑制作用微弱，IC50分别为 32 μM 和 >100 μM。
T63800	ZM223 hydrochloride
	ZM223 hydrochloride 是有效的、非共价的、口服具有活力的 NEDD8 活化酶 (NAE) 抑制剂。
T68059	Ebalzotan
	NAE-086 是一种高亲和力和选择性的5-HT(1A)受体配体，其K(i)值为4.5 nM。
T13412L	ZM223 hydrochloride (2031177-48-5 free base) ZM223 hydrochloride	Serine Protease	Proteases/Proteasome
	ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
T69577	LEI-301
	LEI-301 is a novel potent inhibitor for the PLAAT family members, reducing the NAE levels, including anandamide, in cells overexpressing PLAAT2 or PLAAT5.
T28007	MDPD
	MDPD is an enhancer of the N-acylethanolamine degrading enzyme, fatty acid amide hydrolase, in Arabidopsis. MDPD alleviates the growth inhibitory effects of NAE 12:0, in part by enhancing the enzymatic activity of Arabidopsis FAAH (AtFAAH).
T37530	Glycerophospho-N-Arachidonoyl Ethanolamine
	N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. The different types of NAE can be derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide. AEA is an endogenous cannabinoid neurotransmitter that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibit...
T38049	Glycerophospho-N-Palmitoyl Ethanolamine
	N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. For example, arachidonoyl ethanolamide (AEA) is an endogenous neurotransmitter that evokes cellular responses by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2). The different types of NAE are derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-palmitoyl ethanolamine (GP-NPEA) is the metabo...
T16117	Pevonedistat hydrochloride MLN4924 hydrochloride	Others	Others
	Pevonedistat hydrochloride is an effective and selective inhibitor of NEDD8-activating enzyme (IC50: 4.7 nM).
T13090L	TAS4464	E1/E2/E3 Enzyme	Ubiquitination
	TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).

化合物

Cat.No: T8816

Synonym: NEDD8 inhibitor M22

Target: Apoptosis, E1/E2/E3 Enzyme

Cat.No: T6332

Synonym: MLN4924

Target: E1/E2/E3 Enzyme, NEDD8

TAS4464 hydrochloride

Cat.No: T13090

Target: E1/E2/E3 Enzyme, NEDD8

Cat.No: T5374

Target: E1/E2/E3 Enzyme, NEDD8

Nonaethylene glycol monododecyl ether

Cat.No: T16335

Synonym: Nonaoxyethylene monododecyl ether,Polidocanol,聚醚醇

Target: Others

Cat.No: T124493

Cat.No: T76249L

Naepaine hydrochloride

Cat.No: T33578

Cat.No: T25847

Nonaethylene glycol monomethyl ether

Cat.No: T16336

Target: Others

Cat.No: T76249

Nonaethylene glycol

Cat.No: T16337

Target: Others

Tabernaecorymbosine A

Cat.No: T126132

Cat.No: T13412

Synonym: ZM-223

Target: E1/E2/E3 Enzyme

Cat.No: T16102

Target: E1/E2/E3 Enzyme

ZM223 hydrochloride

Cat.No: T63800

Cat.No: T68059

ZM223 hydrochloride (2031177-48-5 free base)

Cat.No: T13412L

Synonym: ZM223 hydrochloride

Target: Serine Protease

Cat.No: T69577

Cat.No: T28007

Glycerophospho-N-Arachidonoyl Ethanolamine

Cat.No: T37530

Glycerophospho-N-Palmitoyl Ethanolamine

Cat.No: T38049

Pevonedistat hydrochloride

Cat.No: T16117

Synonym: MLN4924 hydrochloride

Target: Others

Cat.No: T13090L

Target: E1/E2/E3 Enzyme

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