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Cat. No. Product Name Target Signaling Pathways
T28124 N106

N-106,N 106

E1/E2/E3 Enzyme Ubiquitination
N106 是 SUMO 激活酶 E1 连接酶的激活剂,并触发 SERCA2a 的内在 sumoylationN106 可用于有关心力衰竭的研究。
T60019 VPC-70063

Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-

Apoptosis; PARP; c-Myc Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair
VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) 是 c-Myc-MAX 的抑制剂。 VPC-70063 的 Myc-Max 转录活性抑制率为 106%,IC50 为 8.9 μM,Myc-Max/UBE2C 下游通路抑制率为 94%。 VPC-70063 可用于抗癌研究。
T35610 2,5-dimethyl Celecoxib

Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂,mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
T36427 PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)

PACAP GPCR/G Protein
Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors on SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 24.5, 106, and 105 nM, respectively) and inhibits cAMP accumulation induced by PACAP (1-38) (Kis = 457, 102, and 283 nM, respectively, in SH-SY5Y, ...

化合物

N106
Cat.No: T28124
Synonym: N-106,N 106
Target: E1/E2/E3 Enzyme
VPC-70063
Cat.No: T60019
Synonym: Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-
Target: Apoptosis, PARP, c-Myc
2,5-dimethyl Celecoxib
Cat.No: T35610
Synonym:
Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor
PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)
Cat.No: T36427
Synonym:
Target: PACAP
TargetMol Loading
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