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16

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T70051	MMI-166
	MMI-166 is a selective matrix metalloproteinase (MMP) inhibitor that prevents tumor invasion and metastasis by downregulating the activity of MMP-2 and MMP-9.
T76242	MMI-0100
	MMI-0100 是一种细胞渗透性肽抑制剂，抑制丝裂原活化蛋白激酶活化蛋白激酶 II (MK2)。MMI-0100 在体内外减少内膜增生。MMI-0100 抑制IL-6表达而不影响IL-8表达。MMI-0100 抑制纤维化过程，例如静脉移植疾病。
T0952	Carbimazole 卡比马唑,Athyromazole,卡比吗唑,Carbimazol,Neomercazole	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Carbimazole (Athyromazole) 是咪唑类甲状腺拮抗试剂，在体内快速转化为 MMI 而发挥作用，在体外可转化为甲咪唑，可用于 Graves 病的研究。
T70050	Boditrectinib
	Boditrectinib 是一种有效的酪氨酸激酶抑制剂。Boditrectinib 是一种抗肿瘤药物。Boditrectinib 可用于癌症、炎症、神经退行性疾病和某些感染性疾病的研究。
T70384	Dolispan
	Dolispan is a Histamine H1 Antagonist.
T60123	Chimmitecan (S)-9-Allyl-10-hydroxycamptothecin,吉米替康	Topoisomerase	DNA Damage/DNA Repair
	Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) 是一种topoisomerase I 抑制剂，在体内、外表现有效的活性。
T63228	Simmiparib SMOCL-9112	Apoptosis; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Simmiparib (SMOCL-9112) 是一种新型有效的 PARP1 和 PARP2 抑制剂，是一种Olaparib 衍生物。Simmiparib 在同源重组修复 (HR) 缺陷细胞中诱导 DNA 双链断裂 (DSB) 和细胞周期阻滞，从而促使细胞凋亡 (apoptosis)。Simmiparib 可用于研究帕金森病、阿尔茨海默病、乳腺癌和黑色素瘤。
T71137	Simmitecan hydrochloride	Topoisomerase	DNA Damage/DNA Repair
	Simmitecan hydrochloride 是一种喜树碱衍生物，是一种拓扑异构酶 I 抑制剂，具有抗癌活性，可用于研究是实体瘤。
T20565	Pseudoakuammigine NSC381082,NSC 381082,NSC-381082
	Pseudoakuammigine is a biochemical substance.
T29805	Akuammicine
	Akuammicine, as an indole alkaloid from Catharanthus roseus, can be used in cancer cell eradication.
T25018	Akuammine
	Akuammine is an antimalarial indolemonoterpene alkaloid from Picralima nitida seeds.
T123809	Eucommin A
	Eucommin A 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T123809，CAS号为 99633-12-2。
T30002	Ammifurin
	Ammifurin is a Furocoumarin mixture used in treatment of vitiligo.
T25098	Antiflammin P2 Hdmnkvldl,Antiflamin 2,His-asp-met-asn-lys-val-leu-asp-leu
	Antiflammin P2 is a nonapeptide fragment of lipocortin I which has no phospholipase A2 inhibitory and anti-inflammatory activity.
T29806	Akuammicine methiodide
	Akuammicine methiodide is a biochemical.
T66029	3,4-Dehydro-L-proline
	The leguminous shrub,Leucaena leucocephala(Leucaena) is wide‐spread in tropical and subtropical agricultural systems and provides a ready source of protein for livestock. However, the presence of mimosine, a non‐protein, amino acid comprising about 12% of the dry matter in growing tips ofLeucaena, is toxic to animals. Mimosine is degraded rapidly in the rumen to produce 3,4‐dihydroxypyridine (3,4‐DHP) and 2,3‐dihydroxypyridine (2,3‐DHP), both of which remain toxic to animals[1]. 3,4-DHP, as a de...

化合物

Cat.No: T70051

Cat.No: T76242

Cat.No: T0952

Synonym: 卡比马唑,Athyromazole,卡比吗唑,Carbimazol,Neomercazole

Target: Thyroid hormone receptor(THR)

Cat.No: T70050

Cat.No: T70384

Cat.No: T60123

Synonym: (S)-9-Allyl-10-hydroxycamptothecin,吉米替康

Target: Topoisomerase

Cat.No: T63228

Synonym: SMOCL-9112

Target: Apoptosis, PARP

Simmitecan hydrochloride

Cat.No: T71137

Target: Topoisomerase

Pseudoakuammigine

Cat.No: T20565

Synonym: NSC381082,NSC 381082,NSC-381082

Cat.No: T29805

Cat.No: T25018

Cat.No: T123809

Cat.No: T30002

Cat.No: T25098

Synonym: Hdmnkvldl,Antiflamin 2,His-asp-met-asn-lys-val-leu-asp-leu

Akuammicine methiodide

Cat.No: T29806

3,4-Dehydro-L-proline

Cat.No: T66029

Cat. No.	Product Name	Target	Signaling Pathways
TQ0240	6"-O-Apiosyl-5-O-Methylvisammioside	Others	Others
	6”-O-Apiosyl-5-O-Methylvisammioside 是中药颈复康的成分之一，颈复康具有活血通络，散风止痛的作用。
T3869	Skimmin 茵芋苷,Skimmine	Others	Others
	Skimmin (Skimmine) 是一种香豆素类物质。存在于圆锥绣球中，能够抑制免疫复合物的沉积，具有抗炎作用。
TN1297	5-O-Methylvisamminol 5-O-甲基维斯阿米醇,5-O-甲维阿斯米醇,5-O-甲基维生素B	Others	Others
	5-O-Methylvisamminol 是一种在植物界中有限存在的呋喃色酮，提取于青冈草。它是很好的菊科植物化学分类学标记，也可用于化学系统发育。
T2S2109	Skimmianine beta-Fagarine,Skimmianin,茵芋碱,Chloroxylonine,Skimmiamine	Others	Others
	Skimmianine (Chloroxylonine) 是一种呋喹啉类生物碱，主要存在于芸香科，具有抗炎、抗痉挛和抗血小板聚集活性。它对多种癌细胞系具有细胞毒性和基因毒性。
TN7098	visamminol-3'-O- glucoside	Others	Others
	visamminol-3'-O- glucoside 是在 Eranthis Salisb 属中检测到 visamminol-3'-O-葡萄糖苷。
T3413	5-O-Methylvisammioside 5-O-Methylvisamminol glucoside,4'-O-β-D-Glucosyl-5-O-methylvisamminol,5-O-甲基维斯阿米醇苷	Others	Others
	5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) 是一种天然产物，分离自防风。
TN6174	Pityrogrammin
	Pityrogrammin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6174，CAS号为 55601-60-0。
TN3368	Akuammigine	Opioid Receptor; Adrenergic Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Akuammigine has in vitro antimalarial activity. Akuammigine competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 4.68. Akuammidine also shows a preference for mu-opioid binding sites with Ki val
TN2325	(Z)-Akuammidine 钩吻素丁	Others	Others
	(Z)-Akuammidine is a natural product
TN6943	visamminol
	visamminol is a natural product.
TN1001	Apiosylskimmin	Others	Others
	Apiosylskimmin is a natural product from Angelica gigas.
T8204	Gummiferin	Others	Others
	Gummiferin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 T8204，CAS号为 33286-30-5。
TN4827	Preskimmianine	Others	Others
	Preskimmianine is the biogenetic precursor of skimmianine.It can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells.
T13537	Akuammiline	Others	Others
	Akuammiline is isolated from the seeds of Picralima klaineana.
TN3367	Akuammidine	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Akuammidine shows anti-inflammatory and anti-asthmatic properties, it has opioid analgesic activity, it shows a preference for mu-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 microM at mu-, delta- and kappa-opioid binding sites, respectively.
T83573	(2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol
	"(2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol" 是 Saposhnikovia divaricata 根部提取的一种糖苷，展现了轻度抗肿瘤活性。
TN6954	Eucommiol
	Eucommiol is a natural product.

天然产物

6"-O-Apiosyl-5-O-Methylvisammioside

Cat.No: TQ0240

Target: Others

Cat.No: T3869

Synonym: 茵芋苷,Skimmine

Target: Others

5-O-Methylvisamminol

Cat.No: TN1297

Synonym: 5-O-甲基维斯阿米醇,5-O-甲维阿斯米醇,5-O-甲基维生素B

Target: Others

Cat.No: T2S2109

Synonym: beta-Fagarine,Skimmianin,茵芋碱,Chloroxylonine,Skimmiamine

Target: Others

visamminol-3'-O- glucoside

Cat.No: TN7098

Target: Others

5-O-Methylvisammioside

Cat.No: T3413

Synonym: 5-O-Methylvisamminol glucoside,4'-O-β-D-Glucosyl-5-O-methylvisamminol,5-O-甲基维斯阿米醇苷

Target: Others

Cat.No: TN6174

Cat.No: TN3368

Target: Opioid Receptor, Adrenergic Receptor

(Z)-Akuammidine

Cat.No: TN2325

Synonym: 钩吻素丁

Target: Others

Cat.No: TN6943

Cat.No: TN1001

Target: Others

Cat.No: T8204

Target: Others

Cat.No: TN4827

Target: Others

Cat.No: T13537

Target: Others

Cat.No: TN3367

Target: Opioid Receptor

(2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol

Cat.No: T83573

Cat.No: TN6954

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