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Cat. No.	Product Name	Target	Signaling Pathways
T6843	GDC-0623 G-868,GDC0623,RG 7421,MEK inhibitor 1	Apoptosis; MEK	Apoptosis; MAPK
	GDC-0623 (RG 7421) 是一种 ATP 竞争性的MEK1抑制剂，Ki 值为 0.13 nM。它对 A375 细胞中 BRAFV600E 的 EC50值为 7 nM，而对 HCT116 细胞中 KRAS (G13D)的 EC50值为 42 nM。
T40206	MEK4 inhibitor-1 MEK4 inhibitor-1
	MEK4 inhibitor-1 is a newly developed compound specifically designed to inhibit the activity of MEK4, a key enzyme involved in pancreatic adenocarcinoma, with an IC 50 value of 61 nM.
T21635	PD184161	MEK	MAPK
	PD 184161 是一种口服有效的，时间和浓度依赖的 MEK 抑制剂，IC50为10-100 nM。它诱导抑郁样行为，抑制细胞增殖并诱导细胞凋亡。
T6971	Ro 5126766 CH5126766,Avutometinib,VS-6766,RO5126766	Raf; MEK	MAPK
	Ro 5126766 (CH5126766) 是双重MEK/RAF 抑制剂，抑制BRAFV600E、CRAF、MEK 和 BRAF，IC50分别为 8.2、56、160 和 190 nM。
T6083	AZD8330 ARRY-424704,ARRY-704	ERK; MEK	MAPK
	AZD8330 (ARRY-704) 是非竞争性的 MEK1/MEK2抑制剂，IC50为 7 nM。
T21332	U0126 U 0126,U-0126	Mitophagy; MEK; Autophagy	Autophagy; MAPK
	U0126 是一种有效的特异性非竞争性 MAP 激酶抑制剂，抑制 MEK-1 和 MEK-2，IC50 值分别为 0.07 和 0.06 μM。 U0126 抑制自噬和线粒体自噬。
T23484	U0124	Others	Others
	Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative control
T10675	MEK-IN-1	MEK	MAPK
	MEK-IN-1 is a MEK inhibitor.
T68855	Hymenialdisine Analogue #1
	Hymenialdisine Analogue #1 is the indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3Β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations.
T74360	MEK/PI3K-IN-1
	MEK/PI3K-IN-1（compound 6r）是一种高效的MEK/PI3K抑制剂，IC50值为124 nM（MEK1）、130 nM（PI3Kα）及236 nM（PI3Kδ）。该化合物能够降低pAKT和pERK1/2的活性，并展现对肿瘤细胞的抗增殖作用。
T74361	MEK/PI3K-IN-2
	MEK/PI3K-IN-2 (compound 6s) 是一种有效的 MEK/PI3K 抑制剂，其 IC50值分别为 352 nM (MEK1), 107 nM (PI3Kα), 和 137 nM (PI3Kδ)。MEK/PI3K-IN-2 抑制 pAKT 和 pERK1/2 水平。MEK/PI3K-IN-2 对肿瘤细胞具有抗增殖活性。
T79048	MEK-IN-6 hydrate	MEK	MAPK
	MEK-IN-6 hydrate（compound 69）为MEK抑制剂，其对A375细胞展现出强效性，IC50仅为2 nM。
T73141	GSK1790627
	GSK1790627 是 Trametinib 的 N-脱乙酰代谢物。Trametinib 是一种具有口服活性的MEK 抑制剂，可激活自噬并诱导细胞凋亡。
T79047	MEK-IN-6	ERK	MAPK
	MEK-IN-6（Example 69）是一种针对MEK的抑制剂，在A375细胞中有效抑制ERK1/2（THR202/Tyr204）的磷酸化，其IC50值为2 nM。此化合物主要应用于癌症研究领域。
T61627	iMDK quarterhydrate
	iMDK quarterhydrate, a potent PI3K inhibitor, is effective in inhibiting the growth factor MDK (also known as midkine or MK) while demonstrating suppression of non-small cell lung cancer (NSCLC). In combination with a MEK inhibitor, iMDK quarterhydrate demonstrates cooperative inhibition of NSCLC without causing harm to normal cells and mice [1].
T69826	U-0126
	U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. It was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with IC50 of 72 nM for MEK1 and 58 nM for MEK2. U0126 inhibited anchorage-independent growth of Ki-ras-transformed rat fibroblasts by simultaneously blocking both extracellular signal-regulated kinase and mammalian target of rapamycin pathways.
T78777	Vem-L-Cy5	Raf	MAPK
	Vem-L-Cy5 (化合物3)是一款改造自Vemurafenib的BRAF抑制剂, 其结构通过近红外荧光团Cy5进行修饰。该化合物针对BRAFV600E具有特异性，并能有效阻断MEK的磷酸化作用。Vem-L-Cy5展现了良好的细胞内渗透能力，并能抑制多种癌细胞系的生长。
T35536	Tpl2 Kinase Inhibitor (hydrochloride)
	Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by calcitriol in HL-60 and U937 leukemia cells when used at a concentration of 5 μM.2Tpl2 kinase inhibitor (5...

化合物

Cat.No: T6843

Synonym: G-868,GDC0623,RG 7421,MEK inhibitor 1

Target: Apoptosis, MEK

MEK4 inhibitor-1

Cat.No: T40206

Synonym: MEK4 inhibitor-1

Cat.No: T21635

Target: MEK

Cat.No: T6971

Synonym: CH5126766,Avutometinib,VS-6766,RO5126766

Target: Raf, MEK

Cat.No: T6083

Synonym: ARRY-424704,ARRY-704

Target: ERK, MEK

Cat.No: T21332

Synonym: U 0126,U-0126

Target: Mitophagy, MEK, Autophagy

Cat.No: T23484

Target: Others

Cat.No: T10675

Target: MEK

Hymenialdisine Analogue #1

Cat.No: T68855

MEK/PI3K-IN-1

Cat.No: T74360

MEK/PI3K-IN-2

Cat.No: T74361

MEK-IN-6 hydrate

Cat.No: T79048

Target: MEK

Cat.No: T73141

Cat.No: T79047

Target: ERK

iMDK quarterhydrate

Cat.No: T61627

Cat.No: T69826

Cat.No: T78777

Target: Raf

Tpl2 Kinase Inhibitor (hydrochloride)

Cat.No: T35536

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