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Search Results for " lak "

Targets Recommended: RAAS

7

抑制剂 & 化合物

2

天然产物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T28950	Terlakiren CP 80794,CP-80,794	RAAS	Endocrinology/Hormones
	Terlakiren (CP-80,794) 是一种具有口服活性和高效性的肾素 (Renin) 抑制剂，抑制人肾素的效能，可用于研究高血压类的神经系统疾病。
T81157	SIGSLAK
	SIGSLAK 拥有与大肠杆菌青霉素结合蛋白 1b (PBP1b) 活性位点相对应的结构特征。
T75404	Galcuronokinase (AtGalAK)
	Galcuronokinase (AtGalAK)属于GHMP激酶家族，催化ATP依赖的α-d-半乳糖醛酸(d-GalA)向α-d-半乳糖醛酸-1-磷酸(GalA-1-P)的转化。
T31753	Food Yellow No. 5 Aluminum Lake C.I. Food Yellow 4:1
	FD&C Yellow No. 5 Aluminum Lake is a synthetic lemon yellow azo dye primarily used as a food coloring.
T30666	C.I. Food Blue 1-aluminum lake EINECS 240-589-3,Indigotine-aluminum lake,Acid Blue 74-aluminum lake,Pigment Blue 63
	C.I. Food Blue 1-aluminum lake is a type of colorant.
T75711	Contulakin G
	Contulakin G为O-糖基化无脊椎动物神经紧张素，作为较弱的神经紧张素受体(neurotensin receptor)激动剂，并具有有效的镇痛作用。
T4134	OTS514 hydrochloride OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))	Apoptosis; TOPK	Apoptosis; MAPK
	OTS514 hydrochloride 是一种高效的TOPK 抑制剂，IC50为 2.6 nM。它可强效抑制 TOPK 阳性的肿瘤细胞生长，诱导细胞周期停滞和凋亡。

化合物

Cat.No: T28950

Synonym: CP 80794,CP-80,794

Target: RAAS

Cat.No: T81157

Galcuronokinase (AtGalAK)

Cat.No: T75404

Food Yellow No. 5 Aluminum Lake

Cat.No: T31753

Synonym: C.I. Food Yellow 4:1

C.I. Food Blue 1-aluminum lake

Cat.No: T30666

Synonym: EINECS 240-589-3,Indigotine-aluminum lake,Acid Blue 74-aluminum lake,Pigment Blue 63

Cat.No: T75711

OTS514 hydrochloride

Cat.No: T4134

Synonym: OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))

Target: Apoptosis, TOPK

Cat. No.	Product Name	Target	Signaling Pathways
T11712	Jasplakinolide Jaspamide,NSC-613009	Microtubule Associated; Antifungal	Cytoskeletal Signaling; Microbiology/Virology
	Jasplakinolide(Jaspamide) 是一种来自海洋海绵 (marine sponge) 的天然环状肽，是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂。Jasplakinolide 具有抗真菌和抗肿瘤活性，可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白，对 F-肌动蛋白的 Kd 值为 15 nM。
TN1702	Glycycoumarin 甘草香豆素	P450; JNK; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Glycycoumarin 是甘草中的一种香豆素，能直接靶向 T-LAK 细胞源蛋白激酶发挥抗肝癌活性。它通过激活自噬，抑制内质网应激介导的 JNK 和 GSK-3 介导的线粒体途径，来抑制肝细胞脂性凋亡。它是一种雌激素激动剂，对 CYP1A2 和 CYP2B6 有中度抑制作用。

天然产物

Cat.No: T11712

Synonym: Jaspamide,NSC-613009

Target: Microtubule Associated, Antifungal

Cat.No: TN1702

Synonym: 甘草香豆素

Target: P450, JNK, AMPK, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00922	ALPK1 Protein, Human, Recombinant (His & Myc) KIAA1527,Lymphocyte alpha-protein kinase,Alpha-protein kinas...	Human	Baculovirus Insect Cells
	ALPK1 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus.
TMPY-04403	NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST) nemo-like kinase,LAK1	Human	Baculovirus Insect Cells
	Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. As a serine/threonine-protein kinase, Nemo-like kinase regulates some transcription factors with key roles in cell fate determination. It is a positive effector of the non-canonical Wnt signaling...
TMPH-02384	Lake Victoria marburgvirus (MARV) (strain Popp-67) L Protein (His & Myc)	MARV	E. coli
	Lake Victoria marburgvirus (MARV) (strain Popp-67) L Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.7 kDa and the accession number is P35262.
TMPH-02385	Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc)	MARV	E. coli
	Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene.
TMPH-02383	Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His)	MARV	E. coli
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling.
TMPH-02382	Lake Victoria marburgvirus (MARV) (strain Angola/2005) Matrix protein VP40 (His & SUMO)	MARV	E. coli
	Plays an essential role virus particle assembly and budding. Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. The interaction with host E3 ubiquitin ligase SMURF2 facilitates virus budding. The interaction with the nucleocapsid and the plasma membrane may also facilitate virus budding. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. May play a role in genome replication.
TMPY-04547	PBK/TOPK Protein, Human, Recombinant (His) HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK	Human	Baculovirus Insect Cells
	PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun...
TMPY-00818	Granzyme H/GZMH Protein, Human, Recombinant (His) CTSGL2,CSP-C,CCP-X,granzyme H,CTLA1,CGL-2,GZMH	Human	HEK293 Cells
	Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens. Several granzymes are potent inducers of cell death. A total of eight granzymes (A-G and M) have been identified in the mouse, but only five are known in humans (A, B, H, M, and granzyme 3), and granzyme H appears to be specifically human. Human granzyme H is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/...

重组蛋白

ALPK1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-00922

Species: Human

Expression System: Baculovirus Insect Cells

NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04403

Species: Human

Expression System: Baculovirus Insect Cells

Lake Victoria marburgvirus (MARV) (strain Popp-67) L Protein (His & Myc)

Cat.No: TMPH-02384

Species: MARV

Expression System: E. coli

Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc)

Cat.No: TMPH-02385

Species: MARV

Expression System: E. coli

Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His)

Cat.No: TMPH-02383

Species: MARV

Expression System: E. coli

Lake Victoria marburgvirus (MARV) (strain Angola/2005) Matrix protein VP40 (His & SUMO)

Cat.No: TMPH-02382

Species: MARV

Expression System: E. coli

PBK/TOPK Protein, Human, Recombinant (His)

Cat.No: TMPY-04547

Species: Human

Expression System: Baculovirus Insect Cells

Granzyme H/GZMH Protein, Human, Recombinant (His)

Cat.No: TMPY-00818

Species: Human

Expression System: HEK293 Cells

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