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Search Results for " kynurenine "

19

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3011L	Kynurenine sulfate monohydrate L-Kynurenine sulfate monohydrate
	Kynurenine sulfate monohydrate is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist agent in the central nervous system. L-Kyn is known to be a pigment generating component in animals. In mamma
T37683	3-Hydroxykynurenine 3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine	Others	Others
	3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) 是色氨酸的活性代谢物，可抑制酵母和大鼠肝脏醛脱氢酶 97% 和 69%。
T72430	L-Kynurenine sulfate
	L-Kynurenine sulfate 是一种芳香烃受体AHR 激动剂，可激活 AHR 导向的初始T 细胞极化至抗炎 Treg 表型。
T1896	Ro 61-8048	Hydroxylase	Metabolism
	Ro 61-8048 是一种选择性的、口服有效的犬尿氨酸 3-羟化酶抑制剂(IC50:37 nM)。它能够导致细胞喹啉酸浓度的显著增加。
T4410	LM10	Others	Others
	LM10 是有效的色氨酸 2,3-双加氧酶的抑制剂。色氨酸 2,3-双加氧酶是一种无关的肝酶，它可通过犬尿氨酸途径降解色氨酸。它对研究癌症疾病具有潜在的研究价值。
T71760	4-Chlorokynurenine
	4-Chlorokynurenine is a prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor.
T28368	PF-04859989 HCl PF 04859989,PF04859989,PF-04859989HCl,PF-04859989	Others	Others
	PF-04859989 HCl 是不可逆的犬尿氨酸转氨酶 KAT II 抑制剂，可透过血脑屏障，抑制 hKATⅡ 和 rKATⅡ 的 IC50分别为 23 和 263 nM。它对 KATⅡ 的选择性高于人 KATⅠ、KATⅢ 和 KATⅣ (IC50分别为22、11和 >50 μM)。
T26785	BFF122 BFF 122,BF5,BFF-122
	BFF122 is an inhibitor of kynurenine aminotransferase II (KAT II).
T70041	GSK065
	GSK065 is a potent inhibitor of kynurenine-3-monooxygenase (KMO).
T15426	GSK180	Hydroxylase	Metabolism
	GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.
T70701	CHDI340246
	CHDI-340246 is a potent and selective kynurenine mono-oxygenase (KMO) inhibitor.
T11470	GSK 366	Hydroxylase	Metabolism
	GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
T13258L	UPF-648	Others	Others
	UPF-648 is a potent kynurenine 3-monooxygenase inhibitor. It also shows highly active at 1 uM (81 ± 10% KMO inhibition).
T13258	UPF-648 sodium salt	Others	Others
	UPF-648 sodium salt is an inhibitor of kynurenine 3-monooxygenase (KMO) and exhibits highly active at 1 uM (81 ± 10% KMO inhibition).
T63613	JM6
	JM6 是弱犬尿氨酸 3-单加氧酶 (kynurenine 3-monooxygenase, KMO) 抑制剂，能够作用于小鼠 KMO (IC50: 19.85 μM)。JM6 能够用于研究阿尔茨海默病。
T4532L	Linrodostat mesylate ONO-7701,BMS-986205,ONO 7701,BMS986205,BMS 986205
	Linrodostat (BMS-986205, ONO-7701, and F001287) is a selective and orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. By inhibiting IDO1 and reducing kynurenine in tumor cells, BMS-986205 restores and promotes the
T69944	NLG802 HCl
	NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indoximod. Indoximod targets, binds to and inhibits the enzyme indoleamine 2,3-dioxygenase (IDO; IDO1), which converts the essential amino acid tryptophan into the immunosuppressive metabolite kynurenine. By increasing tryptophan levels and decreasing kynurenine levels, indoximod res...
T24617	PF-04859989
	PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II.
T73581	HI5
	HI5 是一种有效的微管蛋白 (tublin)和IDO 抑制剂，对 HeLa 细胞的IC50为 70 nM。HI5 抑制IDO 的表达，减少犬尿氨酸的产生，从而刺激 T 细胞活化和增殖。HI5 对 HeLa 细胞可抑制微管蛋白聚合和细胞迁移，引起 G2/M 期阻滞，同时通过线粒体依赖性凋亡途径诱导细胞凋亡 (apoptosis) 并引起反应性氧化应激。HI5 可用于抗癌研究。

化合物

Kynurenine sulfate monohydrate

Cat.No: T3011L

Synonym: L-Kynurenine sulfate monohydrate

3-Hydroxykynurenine

Cat.No: T37683

Synonym: 3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine

Target: Others

L-Kynurenine sulfate

Cat.No: T72430

Cat.No: T1896

Target: Hydroxylase

Cat.No: T4410

Target: Others

4-Chlorokynurenine

Cat.No: T71760

PF-04859989 HCl

Cat.No: T28368

Synonym: PF 04859989,PF04859989,PF-04859989HCl,PF-04859989

Target: Others

Cat.No: T26785

Synonym: BFF 122,BF5,BFF-122

Cat.No: T70041

Cat.No: T15426

Target: Hydroxylase

Cat.No: T70701

Cat.No: T11470

Target: Hydroxylase

Cat.No: T13258L

Target: Others

UPF-648 sodium salt

Cat.No: T13258

Target: Others

Cat.No: T63613

Linrodostat mesylate

Cat.No: T4532L

Synonym: ONO-7701,BMS-986205,ONO 7701,BMS986205,BMS 986205

Cat.No: T69944

Cat.No: T24617

Cat.No: T73581

Cat. No.	Product Name	Target	Signaling Pathways
T4928	L-Kynurenine L-犬尿氨酸,(S)-Kynurenine	AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物，是芳香烃受体激动剂，可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
T10938	D-Kynurenine D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103	GPR; AhR; Endogenous Metabolite	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism
	D-Kynurenine (ZINC901103) 是 D-色氨酸的代谢物和 GPR109B 的激动剂。 D-Kynurenine 激活 AhR 并促进上皮细胞向间充质的转化。 D-Kynurenine 在 D-氨基酸氧化酶的荧光分析中用作底物。
T3011	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸	Others; Endogenous Metabolite	Metabolism; Others
	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (3-Anthraniloylalanine) 是一种酮类和氨基酸衍生物，具有多种生物功能，包括血管舒张、免疫调节和神经调节活性。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是烟酸的前体。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 的异常产生与神经系统疾病相关的认知缺陷和抑郁症状有关。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 在某些类型的癌细胞中过度表达，可能被用作评估癌症风险的生物标志物。
T4096	Quinolinic acid 喹啉酸,pyridine-2,3-dicarboxylic acid,QUIN	Endogenous Metabolite; NMDAR; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Quinolinic acid (QUIN) 是一种内源性 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂，由 L-色氨酸通过犬尿氨酸途径合成，具有调节 NMDA 神经元损伤和功能障碍的潜力。
T4707	3-Hydroxyanthranilic acid 3-HYDROXY-2-AMINOBENZOIC ACID,3-羟基-2-氨基苯甲酸	Others; Endogenous Metabolite	Metabolism; Others
	3-Hydroxyanthranilic acid (3-HYDROXY-2-AMINOBENZOIC ACID) 是犬尿氨酸途径中的色氨酸代谢物。它已在人类表皮和膀胱组织中发现，并且在多种生物体液中也已检测到，例如尿液和血液。在细胞内，它主要位于细胞质中。它存在于从酵母到人类的所有真核生物中。
T80656	Cannflavin A
	Cannflavin A，源自大麻(Cannabis sativa L)，具备抗癌、神经保护及抗炎活性。该化合物有效抑制Aβ1-42的聚集，并阻断犬尿氨酸-3-单加氧酶(KMO)的活性，进而通过caspase-3裂解途径激活细胞凋亡(apoptosis)。

天然产物

Cat.No: T4928

Synonym: L-犬尿氨酸,(S)-Kynurenine

Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite

Cat.No: T10938

Synonym: D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103

Target: GPR, AhR, Endogenous Metabolite

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

Cat.No: T3011

Synonym: Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸

Target: Others, Endogenous Metabolite

Quinolinic acid

Cat.No: T4096

Synonym: 喹啉酸,pyridine-2,3-dicarboxylic acid,QUIN

Target: Endogenous Metabolite, NMDAR, iGluR

3-Hydroxyanthranilic acid

Cat.No: T4707

Synonym: 3-HYDROXY-2-AMINOBENZOIC ACID,3-羟基-2-氨基苯甲酸

Target: Others, Endogenous Metabolite

Cat.No: T80656

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