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Cat. No.	Product Name	Target	Signaling Pathways
T15648	KDM5-C70	Histone Demethylase	Chromatin/Epigenetic
	KDM5-C70 是 KDM5-C49 的乙酯衍生物，是一种有效的细胞渗透性泛 KDM5 组蛋白去甲基化酶抑制剂。它在骨髓瘤细胞中具有抗增殖作用，可诱导全基因组 H3K4me3 水平升高。
T15649	KDM5-IN-1	Histone Demethylase	Chromatin/Epigenetic
	KDM5-IN-1 是一种有效的特异性 KDM5 抑制剂，IC50 为 15.1 nM。
T3576	CPI-455 analogue CPI-455 analogue	Others	Others
	CPI-455 analogue (CPI-455 analogue) 是 CPI-455 的结构类似物，CPI-455 是一种 KDM5 抑制剂。
T39989L	JQKD82 trihydrochloride	Histone Demethylase	Chromatin/Epigenetic
	JQKD82 trihydrochloride 是一种细胞通透性和选择性 KDM5 抑制剂。JQKD82 trihydrochloride 增加 H3K4me3，可用于多发性骨髓瘤的研究。
T27723L	KDM5-C49 HCl KDM5-C49 HCl(1596348-16-1 Free base),KDOAM-20 hydrochloride	Histone Demethylase	Chromatin/Epigenetic
	KDM5-C49 HCl (KDOAM-20 hydrochloride)KDM5-C49 HCl 是一种有效的和具有选择性的去甲基化酶 KDM5抑制剂。KDM5-C49 HCl 是治疗癌症的候选化合物。
T3552	CPI-455 CPI-455 HCl	Histone Demethylase	Chromatin/Epigenetic
	CPI-455 是一种特异性的泛KDM5抑制剂，对 KDM5A 的IC50为 10 nM。它介导 KDM5 抑制，提高 H3K4me3 的整体水平，有抗肿瘤作用。
T5484	GSK467	Histone Demethylase; Histone Methyltransferase	Chromatin/Epigenetic
	GSK467 是一种有效的、选择性的 KDM5 (JARID1) 抑制剂，Ki 值为10 nM。
T15650	KDM5A-IN-1	Histone Demethylase	Chromatin/Epigenetic
	KDM5A-IN-1 是一种可口服且具有高效性和选择性的泛组氨酸赖氨酸脱甲基酶 5 KDM5 抑制剂，抑制 KDM5A，KDM5B，KDM5C，IC50 值分别为 45 nM，56 nM 和 55 nM。KDM5A-IN-1 抑制 PC9 H3K4Me3，可用于研究癌症。
T39989	JQKD82 JADA82,PCK82,JQKD82	Histone Demethylase	Chromatin/Epigenetic
	JQKD82 是 KDM5 的选择性抑制剂，可增加 H3K4me3。 JQKD82可用于治疗多发性骨髓瘤的研究。
T27070	CPI-4203 CPI4203,CPI 4203
	CPI-4203 is a selective inhibitor of KDM5 demethylases.
T27723	KDM5-C49 KDM5C49
	KDM5-C49 is a potent and selective inhibitor of KDM5, which regulates cell proliferation and stem cell self-renewal and differentiation.
T73849	KDM5-C49 hydrochloride
	KDM5-C49 (KDOAM-20) hydrochloride 是一种有效和选择性的KDM5去甲基化酶抑制剂，抑制KDM5A，KDM5B 和KDM5C 的IC50值分别为 40 nM，160 nM 和 100 nM。KDM5-C49 hydrochloride 可用于癌症的研究。
T11749	KDM4-IN-2	Glucokinase	Metabolism
	KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
T11751	KDOAM-25	Antibacterial	Microbiology/Virology
	KDOAM-25, a potent and highly selective inhibitor of histone lysine demethylases 5 (KDM5) with IC50 values of 71 nM for KDM5A, 19 nM for KDM5B, 69 nM for KDM5C, and 69 nM for KDM5D, enhances global H3K4 methylation at transcriptional start sites and reduces proliferation in multiple myeloma MM1S cells.
T22299	CPI-455 HCl	Histone Demethylase	Chromatin/Epigenetic
	CPI-455 is a specific KDM5 inhibitor with IC50 value of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with target
T11750L	KDOAM-25 trihydrochloride (2230731-99-2 free base) KDOAM-25 trihydrochloride	Others	Others
	KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells. KDOAM-25 trihydrochloride is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor
T11750	KDOAM-25 citrate	Others	Others
	KDOAM-25 citrate 是有效且具有高选择性的组蛋白赖氨酸脱甲基酶 5 (KDM5) 抑制剂，对 KDM5A，KDM5B，KDM5C，KDM5D 的IC50分别为 71 nM，19 nM，69 nM，69 nM。用KDOAM-25 citrate 处理的多发性骨髓瘤 MM1S 细胞显示转录起始位点的整体 H3K4 甲基化增加，增殖受损。
T62166	KDOAM-25 trihydrochloride
	KDOAM-25 trihydrochloride 是一种有效的、高度选择性的组蛋白赖氨酸脱甲基酶 5 (KDM5) 抑制剂，能够作用于 KDM5A (IC50: 71 nM)、KDM5B (IC50: 19 nM)、KDM5C (IC50: 69 nM)、KDM5D (IC50: 69 nM)。KDOAM-25 trihydrochloride 能够提高转录起始位点的整体 H3K4 甲基化，可阻碍多发性骨髓瘤 MM1S 细胞的增殖。

化合物

Cat.No: T15648

Target: Histone Demethylase

Cat.No: T15649

Target: Histone Demethylase

CPI-455 analogue

Cat.No: T3576

Synonym: CPI-455 analogue

Target: Others

JQKD82 trihydrochloride

Cat.No: T39989L

Target: Histone Demethylase

Cat.No: T27723L

Synonym: KDM5-C49 HCl(1596348-16-1 Free base),KDOAM-20 hydrochloride

Target: Histone Demethylase

Cat.No: T3552

Synonym: CPI-455 HCl

Target: Histone Demethylase

Cat.No: T5484

Target: Histone Demethylase, Histone Methyltransferase

Cat.No: T15650

Target: Histone Demethylase

Cat.No: T39989

Synonym: JADA82,PCK82,JQKD82

Target: Histone Demethylase

Cat.No: T27070

Synonym: CPI4203,CPI 4203

Cat.No: T27723

Synonym: KDM5C49

KDM5-C49 hydrochloride

Cat.No: T73849

Cat.No: T11749

Target: Glucokinase

Cat.No: T11751

Target: Antibacterial

Cat.No: T22299

Target: Histone Demethylase

KDOAM-25 trihydrochloride (2230731-99-2 free base)

Cat.No: T11750L

Synonym: KDOAM-25 trihydrochloride

Target: Others

KDOAM-25 citrate

Cat.No: T11750

Target: Others

KDOAM-25 trihydrochloride

Cat.No: T62166

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