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Search Results for " jp "

Targets Recommended: Adrenergic Receptor

25

抑制剂 & 化合物

1

天然产物

1

化合物库

4

重组蛋白

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Cat. No.	Product Name
L1010	FDA上市及药典收录分子库		3158 compounds
	3158 个上市及药典分子集合，可用于高通量筛选和高内涵筛选；

化合物库

FDA上市及药典收录分子库

Cat.No: L1010

Compounds: 3158

Cat. No.	Product Name	Target	Signaling Pathways
T24064	Fipamezole JP-1730,BVF-025,JP 1730,JP1730	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Fipamezole 是一种有效的 α2肾上腺素能受体拮抗剂，可能用于研究帕金森病自主神经功能障碍。
T22882	JP1302	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	JP1302 是一种具有选择性的 α2C 肾上腺受体拮抗剂，其对人类 α2C 受体的 Kb 值为 16 nM，Ki 为 28 nM。JP1302 具有抗抑郁活性，可破坏 FACT 复合物并降解组蛋白H1，可用于研究神经精神障碍、急性肾功能衰竭和肾损伤。
T25560	JP-8g JP 8g,JP8g
	JP-8g has an anti-cancer and anti-inflammatory that acts through nitric oxide synthase signaling pathways.
T11726	JP1302 dihydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	JP1302 dihydrochloride 是一种选择性的、高亲和力的α2C 肾上腺受体拮抗剂，其 Kb=16 nM，Ki=28 nM。
T32313	JP7 JP-7,JP 7
	JP7 is a hemoglobin allosteric modifier.
T27321	Fipamezole HCl MPV1730,JP1730,MPV-1730,MPV 1730,JP 1730,JP-1730
	Fipamezole HCl, a α2-adrenoceptor antagonist, is used potentially for the treatment of dyskinesia associated with Parkinson's disease.
T78593	JP104	FAAH	Metabolism; Neuroscience
	JP104为一种氨基甲酸芳基酯类化合物，其具有不可逆FAAH抑制作用，显示出约为8的pIC50值。
T74149	JPD447
	JPD447为MAC-0547630衍生物，属增强β-内酰胺抗生素类新型UppS抑制剂。
TQ0081	JPH203 KYT-0353	Others	Others
	JPH203 (KYT-0353) 是一种 L 型氨基酸转运蛋白 1 (LAT-1) 的抑制剂，具有有效性和特异性。JPH203 可以抑制细胞对亮氨酸的摄取，抑制细胞增殖、诱导细胞凋亡，具有抗炎和抗肿瘤活性。
T8857	LJP-1586 HCl LJP 1586,LJP-1586 hydrochloride,LJP-1586,LJP1586	Others	Others
	LJP-1586 HCl 是一种高选择性的血管粘附蛋白-1（VAP-1）抑制剂，通过减少脑出血（ICH）后粘附分子表达和免疫细胞浸润而显示出抗炎作用。
T11727	JPH203 dihydrochloride KYT-0353 dihydrochloride	Others	Others
	JPH203 dihydrochloride (KYT-0353 dihydrochloride) 是一种酪氨酸类似物，可作为 L 型氨基酸转运蛋白 1 (LAT1) 的选择性抑制剂，用于癌症研究。
T15626	JPM-OEt	Others	Others
	JPM-OEt is a broad spectrum cysteine cathepsin inhibitor with antitumor activity. JPM-OEt binds covalently in the active site and irreversibly inhibits the cysteine cathepsin family.
T74455	JPS035
	JPS035 是一种基于苯甲酰胺的Von Hippel-Lindau (VHL)E3-连接酶蛋白水解靶向嵌合体 (PROTAC)。JPS035 降解 I 类组蛋白脱乙酰酶 (HDAC)。JPS035 是一种有效的 HDAC1/2 降解剂，与 HCT116 细胞中更大的总差异表达基因和增强的细胞凋亡 (apoptosis) 相关。
T27693	JPC-211 JPC 211,PNU-99194A free base
	JPC-211 is an agonist of dopamine-receptor.
T71056	SJP-L-5
	SJP-L-5 is a inhibitor of HIV-1 infection by blocking viral DNA nuclear entry.
T74650	JPE-1375
	JPE-1375 是一种补体C5a 受体 1 (C5aR1) 拮抗剂。JPE-1375 能有效抑制小鼠体内多形核白细胞动员 (EC50=6.9 µM) 和降低TNF 水平 (EC50=4.5 µM)。JPE-1375 可用于自身免疫性和炎性疾病的研究。
T79524	JPC0323	5-HT Receptor	GPCR/G Protein; Neuroscience
	JPC0323为双5-HT2C/5-HT2A受体正变构调节剂，具备良好的靶向性、血浆暴露水平及脑部穿透能力，适用于神经系统疾病研究领域。
T69955	JPI-547 HCl
	JPI 547, also known as NOV 1402, is an oral inhibitor of PARP 1/2 and Tankyrase 1/2. JPI-547 demonstrated anti-tumor activity in BRCA-deficient xenograft models as a single-agent and in combination with chemotherapy and immune checkpoint inhibitors.
T74456	JPS036
	JPS036 是一种基于苯甲酰胺的Von Hippel-Lindau (VHL)E3-连接酶蛋白水解靶向嵌合体 (PROTAC)。JPS036 降解 I 类组蛋白脱乙酰酶 (HDAC)。JPS036 是一种有效的 HDAC1/2 降解剂，与 HCT116 细胞中更大的总差异表达基因和增强的细胞凋亡 (apoptosis) 相关。
T77938	JPS016 TFA	HDAC; PROTACs	Chromatin/Epigenetic; DNA Damage/DNA Repair; PROTAC
	JPS016 TFA是一种苯甲酰胺基Von Hippel-Lindau (VHL) E3连接酶蛋白水解靶向嵌合体(PROTAC)。该化合物能够降解I类组蛋白脱乙酰酶(HDAC)，特别是有效地降解HDAC1/2。在HCT116细胞中，JPS016 TFA与大量差异基因表达增加及细胞凋亡(apoptosis)激活相关。
T74453	JPS014
	JPS014, 基于苯甲酰胺的Von Hippel-Lindau (VHL) E3-连接酶蛋白水解靶向嵌合体 (PROTAC)，有效降解I 类组蛋白脱乙酰酶 (HDAC)。它作为HDAC1/2的强效降解剂，与HCT116细胞中的总差异表达基因更大和增强的细胞凋亡 (apoptosis) 密切相关。
T77966	SJPYT-195
	SJPYT-195为GSPT1降解物，具备细胞毒性，适用于PROTAC合成。
T32315	JPB 25 BRN0977600,JPB25,BRN-0977600,JPB-25,BRN 0977600
	JPB 25 is a bioactive chemical.
T74454	JPS016
	JPS016 是一种基于苯甲酰胺的Von Hippel-Lindau (VHL)E3-连接酶蛋白水解靶向嵌合体 (PROTAC)。JPS016 降解 I 类组蛋白脱乙酰酶 (HDAC)。JPS016 是一种有效的 HDAC1/2 降解剂，与 HCT116 细胞中更大的总差异表达基因和增强的细胞凋亡 (apoptosis) 相关。
T77937	JPS014 TFA	HDAC; PROTACs	Chromatin/Epigenetic; DNA Damage/DNA Repair; PROTAC
	JPS014 TFA是一种VHL E3连接酶蛋白水解靶向嵌合体(PROTAC)，以苯甲酰胺为基础，专门降解I类组蛋白脱乙酰酶(HDAC)。作为一种高效的HDAC1/2降解剂，JPS014 TFA与HCT116细胞中广泛的基因表达差异及促进细胞凋亡(apoptosis)密切相关。

化合物

Cat.No: T24064

Synonym: JP-1730,BVF-025,JP 1730,JP1730

Target: Adrenergic Receptor

Cat.No: T22882

Target: Adrenergic Receptor

Cat.No: T25560

Synonym: JP 8g,JP8g

JP1302 dihydrochloride

Cat.No: T11726

Target: Adrenergic Receptor

Cat.No: T32313

Synonym: JP-7,JP 7

Cat.No: T27321

Synonym: MPV1730,JP1730,MPV-1730,MPV 1730,JP 1730,JP-1730

Cat.No: T78593

Target: FAAH

Cat.No: T74149

Cat.No: TQ0081

Synonym: KYT-0353

Target: Others

Cat.No: T8857

Synonym: LJP 1586,LJP-1586 hydrochloride,LJP-1586,LJP1586

Target: Others

JPH203 dihydrochloride

Cat.No: T11727

Synonym: KYT-0353 dihydrochloride

Target: Others

Cat.No: T15626

Target: Others

Cat.No: T74455

Cat.No: T27693

Synonym: JPC 211,PNU-99194A free base

Cat.No: T71056

Cat.No: T74650

Cat.No: T79524

Target: 5-HT Receptor

Cat.No: T69955

Cat.No: T74456

Cat.No: T77938

Target: HDAC, PROTACs

Cat.No: T74453

Cat.No: T77966

Cat.No: T32315

Synonym: BRN0977600,JPB25,BRN-0977600,JPB-25,BRN 0977600

Cat.No: T74454

Cat.No: T77937

Target: HDAC, PROTACs

Cat. No.	Product Name	Target	Signaling Pathways
TN4015	JP-2 Ethyl(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate	Others	Others
	JP-2 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4015，CAS号为 60263-06-1。

天然产物

Cat.No: TN4015

Synonym: Ethyl(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00732	Cathepsin C Protein, Human, Recombinant (His) DPP-I,PLS,JP,cathepsin C,CPPI,DPPI,PDON1,PALS,DPP1,...	Human	HEK293 Cells
	Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also known as dipeptidyl peptidase I (DPPI/DPP1), activates a number of granule-associated serine proteases with pro-inflammatory and immune functions by removal of their inhibitory N-terminal dipeptides. This lysosomal exo-cysteine protease belonging to the peptidase C1 family. Active c...
TMPY-04061	HIV-2 (subtype CRF01_AB, strain 07JP_NMC716_clone_01) gp36 Protein (His & MBP) GP36	HIV	E. coli
	HIV-2 (subtype CRF01_AB, strain 07JP_NMC716_clone_01) gp36 Protein (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 58.8 kDa and the accession number is L8B302.
TMPH-00065	MRJP1 Protein, Apis mellifera, Recombinant (GST)	Apis mellifera	E. coli
	MRJP1 Protein, Apis mellifera, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 73.9 kDa and the accession number is O18330.
TMPH-00064	MRJP1 Protein, Apis mellifera, Recombinant (His)	Apis mellifera	P. pastoris (Yeast)
	Induces the differentiation of honeybee larvae into queens through an Egfr-mediated signaling pathway. Promotes body size increase by activating p70 S6 kinase, stimulates ovary development by augmenting the titer of vitellogenin (Vg) and juvenile hormone, and reduces developmental time by increasing the activity of mitogen-activated protein kinase and inducing the 20-hydroxyecdysone protein (20E). Most abundant protein found in the royal jelly which is the food of the queen honey bee larva. The ...

重组蛋白

Cathepsin C Protein, Human, Recombinant (His)

Cat.No: TMPY-00732

Species: Human

Expression System: HEK293 Cells

HIV-2 (subtype CRF01_AB, strain 07JP_NMC716_clone_01) gp36 Protein (His & MBP)

Cat.No: TMPY-04061

Species: HIV

Expression System: E. coli

MRJP1 Protein, Apis mellifera, Recombinant (GST)

Cat.No: TMPH-00065

Species: Apis mellifera

Expression System: E. coli

MRJP1 Protein, Apis mellifera, Recombinant (His)

Cat.No: TMPH-00064

Species: Apis mellifera

Expression System: P. pastoris (Yeast)

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