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18

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7265	HSP27 inhibitor J2 J2	HSP	Cytoskeletal Signaling; Metabolism
	HSP27 inhibitor J2 (J2) 是一种HSP27抑制剂，可显著增强 17-AAG 的抗增殖活性，并对顺铂诱导的肺癌细胞生长抑制具有敏感性。它显著诱导异常 HSP27 二聚体形成并抑制HSP27巨聚合物的产生，从而具有抑制HSP27的伴侣功能和降低细胞保护功能的作用。
T11476	GSK-J2	Others	Others
	GSK-J2, an isomer of GSK-J1, haven't any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.
T41328	Delta-12-Prostaglandin J2

T73782	Prostaglandin J2
	Prostaglandin J2 (PGJ2) 是前列腺素 D2 (PGD2) 的一种内源性代谢物，是一种有效的 PGD2 受体 (DP) 激动剂，对 hDP 和 hCRTH2 的 Ki 分别为 0.9 nM 和 6.6 nM。Prostaglandin J2 刺激细胞内环 AMP 的产生，EC50值为 1.2 nM。Prostaglandin J2 诱导氧化应激和神经细胞凋亡。Prostaglandin J2 诱导泛素化 (Ub) 蛋白的积累/聚集。Prostaglandin J2 具有高度神经毒性，可导致许多神经退行性疾病，包括阿尔茨海默病 (AD) 和帕金森病 (PD)。
T68587	Oxmetidine mesylate
	Oxmetidine mesylate is an antagonist to Histamine H2 Receptors
T77644	AJ2-30	Others	Others
	AJ2-30是一种 SLC15A4 抑制剂，抑制 TLR9 介导的 B 细胞活化，抑制 MDP 转运。AJ2-30 抑制人和小鼠巨噬细胞中的内源性 NOD 信号传导。AJ2-30 可用于研究炎症。
T22881	JNJ28871063 hydrochloride JNJ 28871063 hydrochloride	Others	Others
	ErbB receptor family inhibitor
T80432	δ-Buthitoxin-Hj2a	Sodium Channel	Membrane transporter/Ion channel
	δ-Buthitoxin-Hj2a为一种蝎毒肽，具有对NaV1.1通道的高效激动作用，其EC50值为32 nM。它适用于Dravet综合征（DS）的相关研究。
T79543	J27644	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	J27644为一高效HDAC抑制剂，能缓解TGF-β所引发的肺纤维化现象。
T83152	AJ2-71
	AJ2-71为SLC15A4抑制剂，具有抑制IFN-α产生的能力，并能阻断SLC15A4介导的MDP转运，适用于炎症研究。
T70690	UAWJ246
	UAWJ246 is a SARS-CoV-2 Protease inhibitor (IC50 = 45 nM). UAWJ246 provides new directions for the development of Mpro inhibitors as SARS-CoV-2 antivirals.
T11701	J22352	Caspase	Apoptosis; Proteases/Proteasome
	J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblastoma by promoting HDAC6 degradation. It does so by inhibiting autophagy and stimulating the antitumor immune response, further restoring host antitumor activity through the reduction of PD-L1's immunosuppressive activity.
T69572	UAWJ248
	UAWJ248 is a SARS-CoV-2 Protease inhibitor. UAWJ248 provides new directions for the development of Mpro inhibitors as SARS-CoV-2 antivirals.
T80760	XSJ2-46	Influenza Virus	Microbiology/Virology
	XSJ2-46，一种5'-氨基NI类似物，表现为有效的抗病毒药物，尤其针对Zika病毒。它通过抑制RNA依赖性RNA聚合酶（RdRp），展示出其活性，具有8.78 μM的IC50值。
T22820	GSK J5 HCl (1394854-51-3 free base) GSK J5 HCl	Others	Others
	GSK J5 HCl is the hydrochloride form of GSK J5. GSK J5 is an inactive isomer of GSK J4 and a cell-permeable ester derivative of inactive control GSK J2.
T35551	Gallocyanine
	Gallocyanine is a small molecule blue dye used to stain nuclei. It is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Gallocyanine can disrupt the interaction of Dkk1 with its receptor LRP5/6 (IC50 = 3 μM), thereby activating Wnt/β-catenin signaling. Modulation of the Dkk1-LRP5/6 interaction via gallocyanine has been shown to inhibit prostaglandin J2-induced tau phosphorylation at serine396 in primary cortical neurons in vitro.
T36180	Azelaoyl PAF
	Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ. One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF. Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-δ12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.
T35811	CAY10410
	CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ. Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone. CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reactio...

化合物

HSP27 inhibitor J2

Cat.No: T7265

Synonym: J2

Target: HSP

Cat.No: T11476

Target: Others

Delta-12-Prostaglandin J2

Cat.No: T41328

Prostaglandin J2

Cat.No: T73782

Oxmetidine mesylate

Cat.No: T68587

Cat.No: T77644

Target: Others

JNJ28871063 hydrochloride

Cat.No: T22881

Synonym: JNJ 28871063 hydrochloride

Target: Others

δ-Buthitoxin-Hj2a

Cat.No: T80432

Target: Sodium Channel

Cat.No: T79543

Target: HDAC

Cat.No: T83152

Cat.No: T70690

Cat.No: T11701

Target: Caspase

Cat.No: T69572

Cat.No: T80760

Target: Influenza Virus

GSK J5 HCl (1394854-51-3 free base)

Cat.No: T22820

Synonym: GSK J5 HCl

Target: Others

Cat.No: T35551

Cat.No: T36180

Cat.No: T35811

Cat. No.	Product Name	Target	Signaling Pathways
T22473	15-deoxy-Δ-12,14-Prostaglandin J2	Others	Others
	PPARγ agonist
T15277	Fervenulin	Parasite	Microbiology/Virology
	Fervenulin 具有杀灭线虫活性，抑制线虫M. incognita 卵孵化和 J2 的校正死亡率，MIC 分别为 30 μg/mL 和 120 μg/mL。
TN3050	4'-Methoxyflavanone	Others	Others
	4'-Methoxyflavanone 是一种从天然 Isaria fumosorosea KCH J2中分离得到的黄酮类化合物，可用于研究代谢疾病和心血管疾病。
TN5788	Phyllostine
	Phyllostine appears to be their more immediate precursor, since PCMB-treated extracts of J2 converted Phyllostine but not isoepoxydon to these new metabolites.

天然产物

15-deoxy-Δ-12,14-Prostaglandin J2

Cat.No: T22473

Target: Others

Cat.No: T15277

Target: Parasite

4'-Methoxyflavanone

Cat.No: TN3050

Target: Others

Cat.No: TN5788

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