5
52
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T82887 |
Bifikafusp alfa
L19-IL2 |
||
Bifikafusp alfa (L19-IL2) 是一种由人类L19抗体与细胞因子白介素2 (IL2) 结合而成的免疫融合蛋白,特异性针对纤维连接蛋白的EDB区域,并表现出抗癌活性。 | |||
T81917 |
Lorukafusp alfa
hu14.18-IL2,EMD 273063,14.18 mAb |
||
Lorukafusp alfa(14.18 mAb; hu14.18-IL2)是一种由人源化14.18抗GD2抗体和IL210连接而成的免疫细胞因子。该化合物通过其hu14.18-IL2与肿瘤细胞表面的GD2结合,激活抗体依赖性细胞毒性(ADCC)和补体依赖性细胞毒性,以及与效应细胞上Fc受体结合并激活NK和T细胞的活性,从而显现出抗肿瘤效果。 | |||
T77082 | Melredableukin alfa | ||
Melredableukin alfa (RO-7049665)是一种由人IgG1-κ通过多肽连接子与人突变白细胞介素2(IL2 mutin)融合形成的融合蛋白。它适用于乙型肝炎和溃疡性结肠炎的研究。 | |||
T77141 | Pegaldesleukin | ||
Pegaldesleukin 是一种聚乙二醇与白细胞介素-2 的偶联物 (PEG-IL2)。Pegaldesleukin 具有抗病毒活性,在 HIV 中有潜在应用,可能通过保留免疫组库来延缓 HIV 感染的进展。 | |||
T68594 |
NFAT:AP-1 inhibitor-10
|
||
NFAT:AP-1 inhibitor-10 is a novel inhibitor of the NFAT:AP-1:DNA interaction on the ARRE-2 element, binding to DNA in a sequence-selective manner and inhibiting the transcription of the Il2 gene and several other cyclosporin A-sensitive cytokine genes important for the effector immune response. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01464 |
IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F)
TCGF,Aldesleukin,T-Cell Growth Factor,IL-2... |
Human | HEK293 Cells |
Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system,belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages... | |||
TMPJ-01463 |
IL-2 Protein, Human, Recombinant (E. coli)
Aldesleukin,IL-2,IL2,T-C... |
Human | E. coli |
IL-2 Protein, Human, Recombinant (E. coli) is expressed in E. coli expression system. The accession number is P60568. | |||
TMPY-04570 |
ITK Protein, Mouse, Recombinant (aa 351-619, His & GST)
Tcsk,IL2-inducible T-cell kinase,Emt,Tsk |
Mouse | Baculovirus Insect Cells |
ITK Protein, Mouse, Recombinant (aa 351-619, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 58.4 kDa and the accession number is Q03526. | |||
TMPY-05249 |
ITK Protein, Human, Recombinant (Actived By LCK, GST)
LYK,PSCTK2,LPFS1,IL2-inducible T-... |
Human | Baculovirus Insect Cells |
ITK Protein, Human, Recombinant (Actived By LCK, GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 57.7 kDa and the accession number is Q08881. | |||
TMPK-00769 |
IL-2 Protein, Mouse, Recombinant (His & Avi)
白介素,白细胞介素,T-cell growth factor,TCGF,IL2,Al... |
Mouse | HEK293 Cells |
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15,5 - 16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 has essential roles in key functions of the immune system, tolerance and immunity, primarily via its direct effects on T cells. IL-2 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted m... | |||
TMPK-00770 |
IL-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Aldesleukin,IL2,白介素,TCGF,T-cell growth fac... |
Mouse | HEK293 Cells |
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15,5 - 16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 has essential roles in key functions of the immune system, tolerance and immunity, primarily via its direct effects on T cells. IL-2 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. T... | |||
TMPJ-00877 |
IL-2 Protein, Rat, Recombinant (His)
白介素,白细胞介素,IL2,Interleukin-2,TCGF,... |
Rat | HEK293 Cells |
Interleukin-2(IL-2)is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66% and 73% amino acid sequence identity with human and mouse IL-2,respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine... | |||
TMPJ-00036 |
IL-2 Protein, Human, Recombinant (His & Avi), Biotinylated
IL2,IL-2,白介素,Interleukin... |
Human | HEK293 Cells |
IL-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 16-18 KDa and the accession number is P60568. | |||
TMPY-06258 |
IL-2 Protein, Human, Recombinant
TCGF,白细胞介素,lymphokine,白介素,IL-2,interleukin... |
Human | HEK293 Cells |
IL-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.4 kDa and the accession number is P60568. | |||
TMPY-06196 |
IL-2 Protein, Human, Recombinant (His)
白细胞介素,Interleukin-2,lymphokine,TCGF,interleukin |
Human | HEK293 Cells |
IL-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.9 kDa and the accession number is P60568. | |||
TMPY-05090 |
CD25/IL2R alpha Protein, Rat, Recombinant (His)
interleukin 2 receptor, α,CD25/IL... |
Rat | Baculovirus Insect Cells |
CD25/IL2R alpha Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 25.9 kDa and the accession number is A6JLS0. | |||
TMPY-05680 |
CD122/IL2RB Protein, Human, Recombinant (mFc)
CD122,IL15RB,IL-15RB,int... |
Human | HEK293 Cells |
CD122/IL2RB Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 51 kDa and the accession number is P14784. | |||
TMPY-04717 |
CD122/IL2RB Protein, Rhesus, Recombinant (His)
interleukin 2 receptor, β,interleukin 2 re... |
Rhesus | HEK293 Cells |
CD122/IL2RB Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.1 kDa and the accession number is H9Z8K1. | |||
TMPY-05216 |
CD122/IL2RB Protein, Human, Recombinant (His)
IL-15RB,interleukin 2 receptor, β,P70-75,<... |
Human | Baculovirus Insect Cells |
CD122/IL2RB Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P14784. | |||
TMPY-04874 |
IL-23 P19/IL23A Protein, Human, Recombinant (hFc)
IL-23A,IL-23,interleukin... |
Human | HEK293 Cells |
IL-23 P19/IL23A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is Q9NPF7. | |||
TMPY-03776 |
CD25/IL2R alpha Protein, Cynomolgus, Recombinant
interleukin 2 receptor, α,interleukin 2 re... |
Cynomolgus | HEK293 Cells |
CD25/IL2R alpha Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.4 kDa and the accession number is H6WS54. | |||
TMPY-05784 |
CD122/IL2RB Protein, Mouse, Recombinant (hFc)
IL-15Rβ,Il-2/15Rbeta,Il-... |
Mouse | HEK293 Cells |
CD122/IL2RB Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.76 kDa and the accession number is P16297. | |||
TMPY-03644 |
CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His)
interleukin 2 receptor, alpha,CD25/IL<... |
Cynomolgus | HEK293 Cells |
CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.1 kDa and the accession number is H6WS54. | |||
TMPY-04031 |
CD122/IL2RB Protein, Mouse, Recombinant (His)
IL-15Rβ,Il-2/15Rbeta,interleukin ... |
Mouse | HEK293 Cells |
CD122/IL2RB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is P16297. | |||
TMPY-00860 |
CD122/IL2RB Protein, Human, Recombinant
interleukin 2 receptor, β,interleukin 2 re... |
Human | HEK293 Cells |
CD122/IL2RB Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.2 kDa and the accession number is P14784. | |||
TMPY-01103 |
CD25/IL2R alpha Protein, Human, Recombinant (His)
interleukin 2 receptor, α,IL-2RA,... |
Human | HEK293 Cells |
CD25/IL2R alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01589. | |||
TMPY-05644 |
CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated
interleukin 2 receptor, α,CD25/IL... |
Rhesus | HEK293 Cells |
CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24.9 kDa and the accession number is Q5MNY4. | |||
TMPY-05102 |
CD122/IL2RB Protein, Rat, Recombinant (His)
interleukin 2 receptor, β,interleukin 2 re... |
Rat | HEK293 Cells |
CD122/IL2RB Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.4 kDa and the accession number is P26896. | |||
TMPY-05584 |
CD25/IL2R alpha Protein, Human, Recombinant (His & Avi), Biotinylated
CD25,p55,interleukin 2 receptor, alpha,TCG... |
Human | HEK293 Cells |
CD25/IL2R alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25 kDa and the accession number is P01589. | |||
TMPY-01923 |
CD25/IL2R alpha Protein, Mouse, Recombinant (His)
Il2r,CD25,interleukin 2 ... |
Mouse | HEK293 Cells |
CD25/IL2R alpha Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P01590. | |||
TMPJ-00326 |
CD122/IL2RB Protein, Human, Recombinant (aa 27-239, His & Avi), Biotinylated
IL-2R subunit beta,High affinity IL |
Human | HEK293 Cells |
Human IL-2RB, also known asinterleukin-2 receptor subunit beta,is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane protein,and has a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit c... | |||
TMPY-00858 |
CD25/IL2R alpha Protein, Human, Recombinant (hFc)
CD25,interleukin 2 receptor, alpha,IL<... |
Human | HEK293 Cells |
CD25/IL2R alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.5 kDa and the accession number is P01589. | |||
TMPY-04716 |
CD122/IL2RB Protein, Rhesus, Recombinant (hFc)
interleukin 2 receptor, beta,interleukin 2... |
Rhesus | HEK293 Cells |
CD122/IL2RB Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.4 kDa and the accession number is H9Z8K1. | |||
TMPY-03740 |
CD25/IL2R alpha Protein, Cynomolgus, Recombinant (hFc)
interleukin 2 receptor, α,interleukin 2 re... |
Cynomolgus | HEK293 Cells |
CD25/IL2R alpha Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.7 kDa and the accession number is H6WS54. | |||
TMPY-04035 |
CD122/IL2RB Protein, Canine, Recombinant (hFc)
interleukin 2 receptor, beta,interleukin 2... |
Canine | HEK293 Cells |
CD122/IL2RB Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.3 kDa and the accession number is XP_003431552.1. | |||
TMPK-01169 |
IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated
Interleukin-23 subunit α,Interleukin-23 su... |
Mouse | HEK293 Cells |
The heterodimeric cytokine interleukin-23 (IL-23 or IL23A/IL12B) is produced by dendritic cells and macrophages and promotes the proinflammatory and regenerative activities of T helper 17 (Th17) and innate lymphoid cells. A recent study has reported that IL-23 is also secreted by lung adenoma cells and generates an inflammatory and immune-suppressed stroma. | |||
TMPY-00859 |
CD122/IL2RB Protein, Human, Recombinant (hFc)
IL-15RB,interleukin 2 receptor, beta,inter... |
Human | HEK293 Cells |
CD122/IL2RB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.3 kDa and the accession number is P14784. | |||
TMPY-05541 |
CD25/IL2R alpha Protein, Mouse, Recombinant (hFc)
Ly-43,Il2r,interleukin 2 receptor... |
Mouse | HEK293 Cells |
CD25/IL2R alpha Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.4 kDa and the accession number is P01590. | |||
TMPY-05018 |
CD122/IL2RB Protein, Canine, Recombinant (His)
interleukin 2 receptor, beta,interleukin 2... |
Canine | HEK293 Cells |
CD122/IL2RB Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is NP_001273779.1. | |||
TMPY-06515 |
CD122/IL2RB Protein, Human, Recombinant (His & Avi), Biotinylated
P70-75,IL15RB,interleukin 2 receptor, beta... |
Human | HEK293 Cells |
CD122/IL2RB Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 28.73 kDa and the accession number is NP_000869.1. | |||
TMPH-00779 |
IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)
|
Guinea pig | E. coli |
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible fo... | |||
TMPY-06536 |
IL-7RA & IL2RG Heterodimer Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
IL-7RA & IL2RG Heterodimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.54 kDa and the accession number is P16871-1. | |||
TMPY-06646 |
IL-4R & IL2RG Heterodimer Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
IL-4R & IL2RG Heterodimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.74 kDa and the accession number is NP_000409.1. | |||
TMPY-03413 |
PPIL2 Protein, Human, Recombinant (aa 280-457, His)
UBOX7,Cyp-60,CYP60,CYC4,peptidylprolyl isomerase (cycloph |
Human | E. coli |
PPIL2, is an enzyme that belongs to the cyclophilin family. The cyclophilins are peptidylprolyl isomerases and are highly conserved ubiquitous. They play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL2 interacts with the proteinase inhibitor eglin c and is localized in the nucleus. It contains 1 PPIL2 cyclophilin-type domain and 1 U-box domain. PPIL2 accelerate the folding of proteins. It catalyzes the cis-trans isomerization of pro... | |||
TMPY-04987 |
IL-23 P19/IL23A Protein, Human, Recombinant (mFc)
IL-23,interleukin 23, alpha subun... |
Human | HEK293 Cells |
IL-23 P19/IL23A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9NPF7. | |||
TMPJ-00059 |
IL-7 Protein, Human, Recombinant (His)
Interleukin-7,IL7,白细胞介素,IL-7,白介素 |
Human | HEK293 Cells |
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe... | |||
TMPJ-01461 |
IL-15RA & IL-15 Protein, Human, Recombinant (hFc)
IL-15 Receptor α & IL-15 Fusion Protein,In... |
Human | HEK293 Cells |
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ... | |||
TMPJ-01462 |
IL-15RA & IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc)
IL15,IL15RA&IL15,IL-15,I... |
Human | HEK293 Cells |
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ... | |||
TMPH-02806 |
Nav3 Protein, Mouse, Recombinant (His)
|
Mouse | E. coli |
May regulate IL2 production by T-cells. May be involved in neuron regeneration. | |||
TMPJ-00239 |
IL-2RG Protein, Mouse, Recombinant (aa 25-263, hFc)
Il2rg,Interleukin 2 receptor, gam... |
Mouse | HEK293 Cells |
The Interleukin-2 receptor gamma chain (IL-2 Rγ, CD132) of the high affinity functional mouse IL-2 receptor complex is a member the hematopoietin receptor family. It is expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. Common IL2 receptor-γ Chain is required for IL-2 receptor signaling. Besides IL-2, the Common IL2 receptor-γ chain has been shown to be a component of the functional receptor complexes for IL-4, IL-7, IL-9 and IL-15.... | |||
TMPH-02441 |
IL-15 Protein, Rhesus macaque, Recombinant (His)
|
Rhesus | P. pastoris (Yeast) |
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA. In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation. IL-15 Protein, Rhesus macaque, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 1... | |||
TMPH-01557 |
ILF2 Protein, Human, Recombinant (GST)
|
Human | E. coli |
Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. ILF2 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 70.1 kDa and the acce... | |||
TMPH-01796 |
NR4A1 Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury. NR4A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expre... | |||
TMPK-00617 |
IL-13 Protein, Human, Recombinant (His & Avi)
NC30,ALRH,IL13,MGC116786,MGC116789,P600,MGC116788,B... |
Human | HEK293 Cells |
Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macro... | |||
TMPH-02275 |
Lck Protein, Human, Recombinant (His)
|
Human | E. coli |
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules... | |||
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