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Search Results for " ido-in-1 "

20

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7181	IDO-IN-1 4-氨基-N-(3-溴-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-1 是吲哚胺-2,3-双加氧酶抑制剂，IC50=59 nM。
T4142	PCC0208009 IDO inhibitor 1,DO-IN-2,IDO-IN-2	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	PCC0208009 (IDO-IN-2) 是一种有效的 IDO 抑制剂，其在 HeLa 细胞中的 IC50=4.52 nM。它调节 ACC 和杏仁核的突触可塑性，减少神经性疼痛和合并症。
T11901	IDO1-IN-5	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-5 是可透过血脑屏障的、选择性的IDO1抑制剂，能够与缺乏血红素的 apo-IDO1 结合，但无法与成熟血红素的 IDO1 结合。
T11623	IDO/TDO-IN-1	Others	Others
	IDO/TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM).
T20513	IDO1-IN-1 IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1	IDO	Metabolism
	IDO1-IN-1 (2 HzBTZ) 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。
T11624	IDO1-IN-2	IDO	Metabolism
	IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
T12801	(S)-IDO1-IN-5	Others	Others
	(S)-IDO1-IN-5 is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL(IC50 value less than 1.5 µΜ).
T12668	(Rac)-IDO1-IN-5	Others	Others
	(Rac)-IDO1-IN-5 is a racemate of IDO1-IN-5, a potent, selective, and brain-penetrating inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity. It specifically binds to apo-IDO1, which lacks heme, instead of mature heme-bound IDO1.
T39888	IDO1-IN-7 IDO1-IN-7
	IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.
T39839	IDO1-IN-11 IDO1-IN-11
	IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM.
T39946	IDO1-IN-12 IDO1-IN-12
	IDO1-IN-12 is a potent and orally available IDO1 inhibitor.
T11616	IDO-IN-13 GS-4361	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-13 (GS-4361) 是 indoleamine 2,3-dioxygenase 1 抑制剂，EC50=17 nM。
T11619	IDO-IN-5 NLG-1489	IDO	Metabolism
	IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11618	IDO-IN-4	Others	Others
	IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor.
T11621	IDO-IN-8 NLG-1487	IDO	Metabolism
	IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T39089	Acid secretion-IN-1
	Acid secretion-IN-1, a polycyclic compound, is synthesized for its application as an IDO inhibitor in synthetic experiments.
T72056	KYN-101
	KYN-101是一种高效、选择性的芳香烃受体(AHR)合成拮抗剂,在人HepG2 DRE 荧光素酶报告基因检测中IC50为22 nM,在小鼠Hepa1 Cyp-luc 检测中IC50为23 nM。KYN-101逆转IDO/TDO 介导的肿瘤进展,提高PD-1阻断B16 IDO 荷瘤小鼠和表达内源性高水平IDO 的CT26结直肠癌模型的疗效。
T74536	IDO/Tubulin-IN-2
	IDO/Tubulin-IN-2 (HT2) 是一种对TDO和微管蛋白 (tubulin)展现出高效抑制作用的化合物。该抑制剂对多种癌细胞系（包括U87、HepG2、A549、HCT-116和LO2）均表现出强抗肿瘤活性，其半抑制浓度（IC50）分别为0.43、0.036、0.041、0.095和1.04 μM，有效提升了抗肿瘤效果。
T38276	Benzomalvin C
	Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/ml in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.
T40211	eIF4E-IN-1 eIF4E-IN-1
	eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1 functions to disrupt immune suppression and promote immune release in specific diseases such as cancer and infectious diseases.

化合物

Cat.No: T7181

Synonym: 4-氨基-N-(3-溴-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4142

Synonym: IDO inhibitor 1,DO-IN-2,IDO-IN-2

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T11901

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T11623

Target: Others

Cat.No: T20513

Synonym: IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1

Target: IDO

Cat.No: T11624

Target: IDO

(S)-IDO1-IN-5

Cat.No: T12801

Target: Others

(Rac)-IDO1-IN-5

Cat.No: T12668

Target: Others

Cat.No: T39888

Synonym: IDO1-IN-7

Cat.No: T39839

Synonym: IDO1-IN-11

Cat.No: T39946

Synonym: IDO1-IN-12

Cat.No: T11616

Synonym: GS-4361

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T11619

Synonym: NLG-1489

Target: IDO

Cat.No: T11618

Target: Others

Cat.No: T11621

Synonym: NLG-1487

Target: IDO

Acid secretion-IN-1

Cat.No: T39089

Cat.No: T72056

IDO/Tubulin-IN-2

Cat.No: T74536

Cat.No: T38276

Cat.No: T40211

Synonym: eIF4E-IN-1

Cat. No.	Product Name	Target	Signaling Pathways
T4S0051	Coptisine sulfate	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine Sulfate 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T5S0802	Palmatine 巴马汀,Berbericinine,Burasaine	Indoleamine 2,3-Dioxygenase (IDO); AChR; AChE; Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Neuroscience
	Palmatine (Burasaine) 是口服具有活力的、不可逆IDO-1抑制剂。它可以减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，从而改善DSS (Dextran Sulphate Sodium Salt) 诱发的结肠炎。它有用于结肠炎的研究潜力。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。

天然产物

Coptisine sulfate

Cat.No: T4S0051

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T5S0802

Synonym: 巴马汀,Berbericinine,Burasaine

Target: Indoleamine 2,3-Dioxygenase (IDO), AChR, AChE, Aurora Kinase

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

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