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13

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20206	Oxymethurea CSI Paste,1'3-双羟甲基脲,Carbamol,Caurite,Dimethylolurea	Others	Others
	Oxymethurea (CSI Paste) 是一种改性尿素，可在农田中用作缓释肥料。
T32093	Holothurin A
	Holothurin A is a triterpene glycoside.
T32095	Holothurinogenin Nobilisidenol A
	Holothurinogenin, as a lanosterol derivative, has toxic to nerve tissue.
T124549	Ashurbin

T34863	Thurfyl Salicylate Tetrahydrofurfuryl salicylate
	Thurfyl Salicylate (tetrahydrofurfuryl Salicylate) is a redness preparation used for the treatment of musculoskeletal, joint, periarticular, and soft tissue pain.
T32094	Holothurin B
	Holothurin B, as a part of a group of toxins, is originally isolated from the sea cucumber Actinopyga agassizi.
T36493	CMLD-2	Apoptosis; HuR	Apoptosis; Chromatin/Epigenetic
	CMLD-2是一种 HuR-ARE 相互作用的抑制剂（Ki：350 nM），能竞争性地结合 HuR 蛋白并破坏其与富含腺嘌呤元素（ARE）的 mRNA 目标的相互作用。CMLD-2诱导细胞凋亡并通过 MAD2下调表现出抗肿瘤作用。CMLD-2 (1-75 μM ; 24-72 h) 对甲状腺癌细胞的活力具有抑制作用.CMLD-2 (20-30 μM ; 24-48 h) 激活 Caspases 并诱导H1299和A549细胞凋亡.CMLD-2 (30 μM ; 24-48 h) 诱导H1299和A549细胞的G1细胞周期停止和线粒体扰动。 CMLD-2（30μM；24-48小时）减少H1299细胞中HuR 和HuR 调节的mRNAs 和蛋白质的表达.CMLD-2（35μM；72小时）降低SW1736、8505C、BCPAP 和K1细胞的定向迁移能力。CMLD-2诱导SW1736、8505C、BCPAP 和K1细胞中的MAD2 mRNA 水平强烈下降。
T73286	SRI-42127	HuR	Chromatin/Epigenetic
	SRI-42127 是一种新型 RNA 调节因子 HuR 的小分子抑制剂，抑制肿瘤生长，可减弱脂多糖诱导的神经炎症模型中的神经胶质活化，通过抑制神经炎症反应来减轻神经损伤后的神经性疼痛。
T72920	Azaphilone-9 AZA-9
	Azaphilone-9 (AZA-9) 通过结合RNA结合蛋白Hu抗原R (HuR) 抑制HuR-ARERNA相互作用的抑制剂(IC50=1.2 μM)。HuR-RNA相互作用稳定了肿瘤中的许多致癌mRNA。因此，Azaphilone-9可能对抑制癌细胞的生长和进展具有潜力。
T62398	KH-3
	KH-3 是一种 RNA 结合蛋白 Hu 抗原 R (HuR) 的有效抑制剂 (IC50: 0.35 μM)，表现出抗增殖作用。KH-3 能够干扰 HuR–FOXQ1 Mrna 相互作用，抑制乳腺癌细胞侵袭，并延缓肺集落的形成。
T28228	Okicenone
	Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.
T71116	MPT0B098
	MPT0B098 is a potent microtubule inhibitor through binding to the colchicine-binding site of tubulin. MPT0B098 is active against the growth of various human cancer cells, including chemoresistant cells with IC50 values ranging from 70 to 150 nmol/L. MPT0B098 arrests cells in the G2Â–M phase and subsequently induces cell apoptosis. In addition, MPT0B098 effectively suppresses VEGF-induced cell migration and capillary-like tube formation of HUVECs. Distinguished from other microtubule inhibitors, ...
T35993	Epitalon (acetate)
	Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatoni...

化合物

Cat.No: T20206

Synonym: CSI Paste,1'3-双羟甲基脲,Carbamol,Caurite,Dimethylolurea

Target: Others

Cat.No: T32093

Holothurinogenin

Cat.No: T32095

Synonym: Nobilisidenol A

Cat.No: T124549

Thurfyl Salicylate

Cat.No: T34863

Synonym: Tetrahydrofurfuryl salicylate

Cat.No: T32094

Cat.No: T36493

Target: Apoptosis, HuR

Cat.No: T73286

Target: HuR

Cat.No: T72920

Synonym: AZA-9

Cat.No: T62398

Cat.No: T28228

Cat.No: T71116

Epitalon (acetate)

Cat.No: T35993

Cat. No.	Product Name	Target	Signaling Pathways
T3010	Xanthurenic Acid 8-Hydroxykynurenic acid,黄尿酸,4,8-Dihydroxyquinaldic acid,xanthurenate	Apoptosis; Endogenous Metabolite; GluR	Apoptosis; Metabolism; Neuroscience
	Xanthurenic Acid (8-Hydroxykynurenic acid) 是通过 3-羟基犬尿氨酸转氨而由色氨酸代谢产生的分子，可激活 mGlu2/3 代谢型谷氨酸受体。在下丘脑的感觉传输过程中，它被认为是Group II 代谢型谷氨酸受体的激动剂。
TN6277	Phyllanthurinolactone
	Phyllanthurinolactone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6277，CAS号为 168180-12-9。
TN1574	Dhurrin	Others	Others
	Dhurrin is a natural product
TN6587	Clemomandshuricoside B
	Clemomandshuricoside B 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6587，CAS号为 905294-48-6。
TN3653	Cimidahurinine	BCL; ROS	Apoptosis; Immunology/Inflammation
	Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity by decreasing reactive oxygen species (ROS) accumulation and downregulating apoptosis-related Bax/Bcl-2 proteins.
TN1510	Clematomandshurica saponin B	COX	Immunology/Inflammation; Neuroscience
	Clematomandshurica saponin B shows significant inhibitory activity on cyclooxygenase-2 (IC50 = 2.58 microM).
TN1509	Clematomandshurica saponin C Clematiunicinoside E	Others	Others
	Clematiunicinoside E is a natural product from Clematis uncinata.
T13636	Dahurinol	Others	Others
	Dasalinol is a natural compound isolated from the cedar (Cimicifuga acerina).

天然产物

Xanthurenic Acid

Cat.No: T3010

Synonym: 8-Hydroxykynurenic acid,黄尿酸,4,8-Dihydroxyquinaldic acid,xanthurenate

Target: Apoptosis, Endogenous Metabolite, GluR

Phyllanthurinolactone

Cat.No: TN6277

Cat.No: TN1574

Target: Others

Clemomandshuricoside B

Cat.No: TN6587

Cat.No: TN3653

Target: BCL, ROS

Clematomandshurica saponin B

Cat.No: TN1510

Target: COX

Clematomandshurica saponin C

Cat.No: TN1509

Synonym: Clematiunicinoside E

Target: Others

Cat.No: T13636

Target: Others

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