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16

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T15500	HPi1	Others; Antibacterial	Microbiology/Virology; Others
	HPi1 是一种有口服活性的，针对幽门螺杆菌的选择性抗菌剂，IC50为 0.24 μM，MIC 为 0.08-0.16 μg/mL。
T6415	Bismuth Subcitrate Potassium	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Bismuth subcitrate potassium 是针对 12 种幽门螺杆菌菌株的抗生素，MIC50为 8 μg/ml。它用于幽门螺杆菌感染的上胃肠道疾病的研究。
T34093	pNNP p NNP,p-Nitrophenyl phosphate,p-NNP,Nitrophenylphosphate	Carbonic Anhydrase	Metabolism
	pNNP (Nitrophenylphosphate) 可用作 PP2C 试验的底物。pNNP 对β-碳酸酐酶和α-碳酸酯脱水酶有抑制作用，对幽门螺杆菌幽门螺杆菌也具有抑制作用。pNNP 是一种活性较弱的组织非特异性碱性磷酸酶调节剂。
T27375	FR-182024 FR 182024,FR182024
	FR-182024 is a novel cephem derivative, it has potent anti-Helicobacter pylori activity.
T27999	MDK-4624 AMPKα1 activator C13,C13, Compound 13
	MDK-4624 is a AMPKα1 activator. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 potently inhibits melanoma cell proliferation
T61623	Ecabet
	Ecabet sodium (TA-2711) is a chemical compound utilized for the clinical treatment of gastrointestinal disease through the suppression of reactive oxygen species (ROS) generation and enhancement of Helicobacter pylori eradication [1]. Moreover, Ecabet sodium effectively attenuates apoptosis [2].
T71059	Ranitidine bismuth citrate IST 622,雷尼替丁枸橼酸盐
	Ranitidine bismuth citrate 为一种口服活性的组胺H2受体(Histamine H2-receptor)拮抗剂，其IC50值为3.3 μM，对SARS-CoV-2感染细胞显示高选择性。该化合物还是治疗幽门螺杆菌(Helicobacter Pylori)感染的常用试剂，其MIC90为16 ng/L。
T75420	alpha-1,3/4-Fucosyltransferase (α1,3/4FucT)
	alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) (Hp3/4FT) 存在于幽门螺杆菌中。alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) 催化岩藻糖从供体 GDP-β-l-岩藻糖转移到 GlcNAc。
T11289	Finafloxacin	Others	Others
	Finafloxacin, a fluoroquinolone antimicrobial agent from a new 8-cyano subclass, is most effective in slightly acidic environments (pH 5.0-6.0), a condition where other fluoroquinolones typically reduce in activity. It selectively targets bacterial type II topoisomerases, such as DNA gyrase and DNA topoisomerase IV, making it suitable for treating serious bacterial infections particularly in acidic contexts, including urinary tract infections (UTIs) and Helicobacter pylori infections.
T16749	Rifalazil 利福拉齐,KRM-1648,ABI-1648	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Rifalazil is a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis (MIC: 0.00025 to 0.0025 μg/ml).
T38581	Antofloxacin
	Antofloxacin is a well-tolerated, orally active, and broad-spectrum 8-amino-fluoroquinolone compound that exhibits potent antibacterial properties. It demonstrates superior activity against gyrA mutation-positive Helicobacter pylori strains, particularly in strains with mutations in the Asn87 position, when compared to levofloxacin. Additionally, Antofloxacin acts as a weak but reversible inhibitor of CYP1A2 and is clinically used to treat infections caused by various bacterial species.
T76107	Urease
	Urease 由多种类型细菌产生，是一些致病菌的有效毒力因子。Urease 还是幽门螺杆菌代谢和毒力的中心，帮助其在胃粘膜中定植。
T61643	Vonoprazan hydrochloride
	Vonoprazan hydrochloride 是一种高效且具口服活性的质子泵抑制剂 (PPI) 和钾竞争性酸阻断剂 (potassium-competitive acid blocker, P-CAB)，展示出优秀的抗分泌活性。在 pH 为 6.5 的条件下，该化合物可抑制猪胃微粒体内 H+,K+-ATPase 的酶活性，呈现出 19 nM 的 IC50 值。Vonoprazan hydrochloride 主要应用于胃酸相关疾病的研究，包括胃食管反流病和消化性溃疡，并可用于根除幽门螺杆菌。
T35840	4-Amino-6-chloro-1,3-benzenedisulfonamide
	4-Amino-6-chloro-1,3-benzenedisulfonamide is a carbonic anhydrase inhibitor.1 Formulations containing this compound are diuretics.2 4-Amino-6-chloro-1,3-benzenedisulfonamide is detected as a hydrolysis product of chlorothiazide in the urine.2 Diuretics, including chlorothiazide, have been abused as performance-enhancing drugs and masking agents in sports doping.3References1. Nishimori, I., Vullo, D., Minakuchi, T., et al. Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies ...
T8761	[Leu15]-Gastrin I human Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2	Others	Others
	[Leu15]-Gastrin I human (Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2) 基因编码人体内的蛋白质 [Leu15]-胃泌素 I。在人类染色体中，GAST 基因定位于 17q21.2。胃窦中的 G 细胞产生 [Leu15]-胃泌素 I 的前体前胃泌素。前胃泌素经过裂解和加工产生胃泌素，它对整个胃肠道上皮细胞具有营养作用。胃泌素对消化系统的生长至关重要，并刺激壁细胞产生胃酸。胃泌素通过称为胆囊收缩素(CCK) 或 CCK-B 受体 (CCK-BR) 的 G 蛋白偶联受体发挥其功能。胃泌素的释放受到食物的刺激，尤其是蛋白质饮食，并受到非常低的 pH 值的抑制。萎缩性胃炎、幽门螺杆菌感染和长期服用质子泵抑制剂感染可能导致胃泌素过度表达。胃腺癌显示高水平的胃泌素。
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

化合物

Cat.No: T15500

Target: Others, Antibacterial

Bismuth Subcitrate Potassium

Cat.No: T6415

Target: Others, Antibacterial, Antibiotic

Cat.No: T34093

Synonym: p NNP,p-Nitrophenyl phosphate,p-NNP,Nitrophenylphosphate

Target: Carbonic Anhydrase

Cat.No: T27375

Synonym: FR 182024,FR182024

Cat.No: T27999

Synonym: AMPKα1 activator C13,C13, Compound 13

Cat.No: T61623

Ranitidine bismuth citrate

Cat.No: T71059

Synonym: IST 622,雷尼替丁枸橼酸盐

alpha-1,3/4-Fucosyltransferase (α1,3/4FucT)

Cat.No: T75420

Cat.No: T11289

Target: Others

Cat.No: T16749

Synonym: 利福拉齐,KRM-1648,ABI-1648

Target: DNA/RNA Synthesis

Cat.No: T38581

Cat.No: T76107

Vonoprazan hydrochloride

Cat.No: T61643

4-Amino-6-chloro-1,3-benzenedisulfonamide

Cat.No: T35840

[Leu15]-Gastrin I human

Cat.No: T8761

Synonym: Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2

Target: Others

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

Cat. No.	Product Name	Target	Signaling Pathways
TN1213	2-(Hydroxymethyl)anthraquinone	Anti-infection	Microbiology/Virology
	2-(Hydroxymethyl)anthraquinone 是光可清除保护基团，在结构上可以阻碍性信息素释放。
TN5173	Trichorabdal A	Antifection	Microbiology/Virology
	Trichorabdal A 是一种二萜化合物，分离自 Rabdosia trichocarpa，抗肿瘤作用强大。
TN6733	Kansuiphorin C KPC,甘遂大戟萜酯C	Others	Others
	Kansuiphorin C (KPC) 是一种具有多种生物活性的天然产物。它能够调节肠道菌群及相关代谢功能，并可以改善恶性腹水。
TN1733	Hesperetin 7-O-glucoside	Anti-infection; Antibacterial; HMG-CoA Reductase	Metabolism; Microbiology/Virology
	Hesperetin 7-O-glucoside 是通过 Hesperidin 的酶促转化产生的一种人 HMG-CoA 还原酶抑制剂，具有降压作用，可抑制幽门螺杆菌的生长。
T3831	Licoricone	Antifection	Microbiology/Virology
	Licoricone exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains.
T28834	Spirolaxine
	Spirolaxine, a natural product isolated from Sporotrichum laxum ATCC 15155, has shown a variety of biological activities including promising anti-Helicobacter pylori property.
TN1699	Glyasperin D 粗毛甘草素 D,粗毛甘草素D	Antifection	Microbiology/Virology
	Glyasperin D possesses weak anti-Helicobacter pylori activity.
TN4579	Monomethylsulochrin	Antifection	Microbiology/Virology
	Monomethylsulochrin shows antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. It shows moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with the MIC value of 28.9+/-0.1 microM.
TN1099	Dihydroevocarpine	MAO; P-gp; Antifection	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it shows more potent inhibitory effects against MAO-B compared to MAO-A.
T38252	Lacto-N-biose I
	Lacto-N-biose I, also known as Galβ1-3GlcNAc, is a naturally occurring metabolite that serves as a substrate for the α1,2-fucosyltransferase enzyme derived from Helicobacter pylori[1].
TMA2418	1-Methoxyphaseollidin	PAFR; Antifection	GPCR/G Protein; Microbiology/Virology
	1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Methoxyphaseollidin may show moderate cytotoxic activity against KB and L1210 cells. 1-Methoxyphaseollidin also shows inhibition of lysoPAF acetyltransferase activity.
T75507	1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone
	1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone 对幽门螺杆菌菌株 51 表现出有效的抗菌活性，MIC50 值和 MIC90 值分别为 22 µM 和 50 µM。该化合物展现了在研究胃及十二指肠溃疡方面的潜力。
T75697	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone，为喹诺酮类生物碱，作用为二酰基甘油酰基转移酶抑制剂与血管紧张素II受体阻断剂，其IC50值依次为20.1 μM与34.1 μM。此化合物亦展现对幽门螺杆菌的有效抗活性，MIC值达10 μg/mL。

天然产物

2-(Hydroxymethyl)anthraquinone

Cat.No: TN1213

Target: Anti-infection

Cat.No: TN5173

Target: Antifection

Cat.No: TN6733

Synonym: KPC,甘遂大戟萜酯C

Target: Others

Hesperetin 7-O-glucoside

Cat.No: TN1733

Target: Anti-infection, Antibacterial, HMG-CoA Reductase

Cat.No: T3831

Target: Antifection

Cat.No: T28834

Cat.No: TN1699

Synonym: 粗毛甘草素 D,粗毛甘草素D

Target: Antifection

Monomethylsulochrin

Cat.No: TN4579

Target: Antifection

Dihydroevocarpine

Cat.No: TN1099

Target: MAO, P-gp, Antifection

Lacto-N-biose I

Cat.No: T38252

1-Methoxyphaseollidin

Cat.No: TMA2418

Target: PAFR, Antifection

1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone

Cat.No: T75507

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

Cat.No: T75697

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