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21

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9597	H2S Donor 5a N-(苯甲酰基硫基)苯甲酰胺	Endogenous Metabolite	Metabolism
	H2S Donor 5a 是一种稳定的、半胱氨酸活化的的 H2S 供体。它是研究 H2S 的有用工具。
T37720	Difluorinated H2S Fluorescent Probe 1
	Difluorinated H2S probe 1 is a fluorescent probe for hydrogen sulfide (H2S).1It selectively fluoresces in the presence of H2S over Zn2+, Fe3+, S2O32-, ClO-, SO32-, H2O2, NO2-, cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) when used at a concentration of 1 μM. Difluorinated H2S probe 1 displays excitation/emission maxima of 365/450 nm, respectively. 1.Zhang, J., Gao, Y., Kang, X., et al.o,o-Difluorination of aromatic azide yields a fast-response fluorescent probe for H2S detection and...
T22830	GYY4137 GYY 4137 morpholine salt	Others	Others
	GYY4137 (GYY 4137 morpholine salt) 是一种缓释H2S 供体，具有抗炎和抗癌作用，也具有血管扩张和抗高血压活性。
T3560	Desmethylanethol trithione ADT-OH	VEGFR; Akt	Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Desmethylanethol trithione (ADT-OH) 是合成硫化氢的供体。它利用上调 FADD 诱导细胞凋亡，并对体内黑色素瘤的形成具有一定的抑制作用，可用于研究癌症疾病。
T61316	HTS07545	NADPH	Metabolism
	HTS07545 是一种有效的硫化物:醌氧化还原酶抑制剂（IC50： 30 nM）。HTS07545 可降低硫化氢 (H2S) 的分解速率。HTS07545 可用于研究心力衰竭。
T36503	Sodium Hydrogen Sulfide (hydrate)	Others	Others
	Sodium Hydrogen Sulfide (hydrate) 与一氧化氮一样，是一种重要的气体介质，对哺乳动物的免疫、神经、心血管和肺系统有重要影响。Sodium Hydrogen Sulfide (hydrate)是一种H2S 供体，常用于细胞和整个动物实验系统。例如，它被用来证明H2S 促进中性粒细胞迁移，减少气道炎症，保护神经轴突、心脏和肠道免受化学或缺血再灌注损伤。
T36240	AP219
	AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion.
T35860	AP39
	AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an i...
T32293	JK-2 lithium JK-2,JK2,JK 2
	JK-2 is a hydrogen sulfide (H2S) donor. At acidic pH, it shows a greatly accelerated H2S release upon protonation-induced intramolecular cyclization.
T38370	CAY10731
	CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).[1] Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm, respectively. CAY10731 is selective for H2S over glutathione (GSH), cysteine, H2O3-, SO3-, and H2O2 as well as tBuO and OH radicals. It has been used to detect H2S in rat hippocampal slices and nematodes.
T38117	WSP-5 Washington State Probe-5,WSP-5
	Hydrogen sulfide (H2S) is an important gaseous mediator, like nitric oxide, that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. WSP-5 is a reactive disulfide-containing, fluorescent probe designed for fast detection of H2S in biological samples and cells. Through a reaction-based fluorescent turn-on strategy, WSP-5 selectively and rapidly reacts with H2S, generating a fluorophore with excitation and emission maxima of 502 and 525 nm, ...
T35323	ZYZ-803 ZYZ 803
	ZYZ-803 is a slow H2S-NO-releasing hybrid, attenuating cardiac dysfunction after heart failure.
T19728	SPRC S-Propargyl-cysteine
	SPRC is a novel synthetic molecule exerting antioxidant effects via elevating the generation of endogenous H2S. SPRC activates Gp130-mediated STAT3 and prevents doxorubicin-induced cardiotoxicity.
T81396	PRO-F
	PRO-F是一种光活化H2S供体，具备ROS清除功能。该化合物通过光激活能生成荧光信号，实现H2S释放的实时追踪；其激活过程不耗费内源性成分。PRO-F在细胞内提供H2S，以防止ROS过量造成的细胞损害，并已在慢性伤口愈合和糖尿病模型中展现出促进效果。
T36965	CAY10732 CAY-10732,CAY 10732
	CAY10732 是一种检测硫化氢的荧光剂，可用于检测活细胞中 H2S 成像。
T15361	FW1256	Others	Others
	FW1256 is a phenyl analog. It also a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and causes cell apoptosis. FW1256 shows potent anti-inflammatory effects. It also has the potential for cancer and cardiovascular disease trea
T36223	MitoA
	MitoA is a ratiometric mass spectrometry probe that can be used for assessing changes in H2S within mitochondria in vivo. MitoA contains a triphenylphosphonium cation component that drives its accumulation in mitochondria where its aryl azide moiety selectively reacts with H2S to produce an amine product, MitoN. Quantifying the MitoN/MitoA ratio by LC-MS/MS reflects the mitochondrial matrix H2S concentration. In a mouse model of acute myocardial infarction with MitoA administered prior to ischem...
T37000	7-Azido-4-methylcoumarin
	7-Azido-4-methylcoumarin (AzMC) is a coumarin fluorescent probe for hydrogen sulfide (H2S).1 AzMC selectively fluoresces in the presence of H2S over a panel of reactive nitrogen, oxygen, and sulfur species. AzMC displays excitation/emission maxima of 340/445 nm, respectively. \|1. Chen, B., Li, W., Lv, C., et al. Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues. Analyst 138(3), 946-951 (2013).
T34741	Sulfidefluor-7 AM SF7-AM
	Sulfidefluor-7 AM (SF7-AM) 是一种有效的和具有细胞渗透性的硫化氢(h2s)荧光探针。Sulfidefluor-7 AM 含有乙酰氧基甲酯，在细胞内水解以捕获探针。
T21939	ATB-337
	S-Diclofenac 的分子结构由 H2S 供体和非甾体类抗炎药双氯芬酸组合而成。S-Diclofenac 显著抑制前列腺素的合成，并且不会损伤胃粘膜。
T83768	Zofenoprilat Zofenopril-SH,SQ 26,333
	Zofenoprilat是一种血管紧张素转换酶(ACE; IC50 = 8 nM for the rabbit lung enzyme)的抑制剂，同时也是前体药zofenopril的活性代谢产物。它能够抑制分离的豚鼠小肠中由血管紧张素I或缓激肽诱导的收缩(EC50s = 3 and 1 nM, respectively)。在人类脐静脉内皮细胞(HUVECs)中，Zofenoprilat (10 nM)降低基础内皮素-1分泌和一氧化氮(NO)生成，并阻止TNF-α诱导的活性氧种(ROS)增加以及谷胱甘肽(GSH)水平降低。Zofenoprilat (10 µM)保护初级人类心脏微血管内皮细胞免受多柔比星诱导的细胞毒性。此外，Zofenoprilat (10 µM)还能增加HUVECs中的硫化氢(H2S)生成，以及细胞的黏着、迁移和增殖。在以400 µM浓度使用时，它可以减少Langendorff分离的大鼠心脏灌流缺血再灌注损伤模型中的舒张末压和乳酸脱氢酶(LDH)释放。

化合物

Cat.No: T9597

Synonym: N-(苯甲酰基硫基)苯甲酰胺

Target: Endogenous Metabolite

Difluorinated H2S Fluorescent Probe 1

Cat.No: T37720

Cat.No: T22830

Synonym: GYY 4137 morpholine salt

Target: Others

Desmethylanethol trithione

Cat.No: T3560

Synonym: ADT-OH

Target: VEGFR, Akt

Cat.No: T61316

Target: NADPH

Sodium Hydrogen Sulfide (hydrate)

Cat.No: T36503

Target: Others

Cat.No: T36240

Cat.No: T35860

Cat.No: T32293

Synonym: JK-2,JK2,JK 2

Cat.No: T38370

Cat.No: T38117

Synonym: Washington State Probe-5,WSP-5

Cat.No: T35323

Synonym: ZYZ 803

Cat.No: T19728

Synonym: S-Propargyl-cysteine

Cat.No: T81396

Cat.No: T36965

Synonym: CAY-10732,CAY 10732

Cat.No: T15361

Target: Others

Cat.No: T36223

7-Azido-4-methylcoumarin

Cat.No: T37000

Sulfidefluor-7 AM

Cat.No: T34741

Synonym: SF7-AM

Cat.No: T21939

Cat.No: T83768

Synonym: Zofenopril-SH,SQ 26,333

Cat. No.	Product Name	Target	Signaling Pathways
T10933	D-Cysteine	Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	D-Cysteine 是一种大肠杆菌生长的有力抑制剂，是半胱氨酸的 D 型异构体。它由 D-氨基酸氧化酶介导产生 H2S，是一种对抗小脑共济失调的神经保护剂。 D-半胱氨酸可以抑制由变形链球菌和链球菌血红蛋白形成的两种生物膜的生长和致龋性。
T1285	Anethole trithione 茴三硫,Anetholtrithion	Others; AChR	Neuroscience; Others
	Anethole trithione (Anetholtrithion) 是硫杂环胆碱，是一种胆汁分泌刺激剂，可增强唾液分泌并增加 mAChR 受体，用于口干症的研究。
T2O2721	L-Cysteine Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine	Endogenous Metabolite	Metabolism
	L-Cysteine (L-(+)-Cysteine) 是人体非必需的含硫氨基酸。L-Cysteine 对蛋白质合成、解毒和多种代谢功能很重要。L-Cysteine 存在于指甲、皮肤和头发的主要蛋白质-角蛋白中，对胶原蛋白的生成、皮肤弹性和质地都很重要。L-Cysteine 是抗氧化剂谷胱甘肽的一种成分，在辅酶A、肝素和生物素等基本生化物质的代谢中起着重要作用，也是氨基酸牛磺酸的制造所必需的。
T8693	Diallyl Trisulfide 二烯丙基三硫化物,二烯丙基三硫醚	Apoptosis; Reactive Oxygen Species; Antifungal	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Diallyl Trisulfide 是一种在大蒜中发现的有机多硫化物，可作为 H2S 供体。它抑制扩张性青霉的生长，有抗癌能力。
TN5283	L-Cysteine hydrochloride hydrate L-Cysteine hydrochloride monohydrate,L-半胱氨酸盐酸盐一水物,L-半胱氨酸盐酸盐一水合物	Others; Endogenous Metabolite	Metabolism; Others
	L-Cysteine hydrochloride hydrate (L-Cysteine hydrochloride monohydrate) 是条件必需氨基酸，是硫化氢、谷胱甘肽和牛磺酸等生物活性分子的前体。它可以抑制胃饥饿素，抑制啮齿动物和人类的食欲。
T8141	L-Cysteine hydrochloride L-Cysteine HCl,L-半胱氨酸盐酸盐,L-半胱氨酸盐酸盐(无水物)	Others; Endogenous Metabolite	Metabolism; Others
	L-Cysteine hydrochloride (L-Cysteine HCl) 是一种条件必需氨基酸，是硫化氢 (H2S)、牛磺酸谷胱甘肽和等生物特性分子的前体。它能抑制胃饥饿素，抑制啮齿动物和人类的食欲。

天然产物

Cat.No: T10933

Target: Endogenous Metabolite, Antibacterial

Anethole trithione

Cat.No: T1285

Synonym: 茴三硫,Anetholtrithion

Target: Others, AChR

Cat.No: T2O2721

Synonym: Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine

Target: Endogenous Metabolite

Diallyl Trisulfide

Cat.No: T8693

Synonym: 二烯丙基三硫化物,二烯丙基三硫醚

Target: Apoptosis, Reactive Oxygen Species, Antifungal

L-Cysteine hydrochloride hydrate

Cat.No: TN5283

Synonym: L-Cysteine hydrochloride monohydrate,L-半胱氨酸盐酸盐一水物,L-半胱氨酸盐酸盐一水合物

Target: Others, Endogenous Metabolite

L-Cysteine hydrochloride

Cat.No: T8141

Synonym: L-Cysteine HCl,L-半胱氨酸盐酸盐,L-半胱氨酸盐酸盐(无水物)

Target: Others, Endogenous Metabolite

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