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Search Results for " glucagon-like peptide 2 "

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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1157	GLP-2(1-33)(human) GLP-2 (human),Glucagon-like peptide 2 (human)
	GLP-2(1-33) (human) is an enteroendocrine hormone which stimulates the growth of the intestinal epithelium.
T19850L	Semaglutide Acetate 索玛鲁肽醋酸盐,Semaglutide Acetate(910463-68-2 Free base)	Glucagon Receptor	GPCR/G Protein
	Semaglutide Acetate 是胰高血糖素样肽 1 (GLP-1) 受体的激动剂，可用于治疗 2 型糖尿病的研究。
TP1469	Lixisenatide acetate (320367-13-3 free base) Lixisenatide acetate	Glucagon Receptor	GPCR/G Protein
	Lixisenatide acetate 是一种胰高血糖素样肽 1 受体的激动剂，可用于研究 2 型糖尿病。
T76279L1	Retatrutide sodium salt Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt	Glucagon Receptor	GPCR/G Protein
	Retatrutide sodium salt 是一种有效的胰高血糖素受体 (GCGR)、葡萄糖依赖性促胰岛素多肽受体 (GIPR) 和胰高血糖素样肽-1 受体 (GLP-1R) 的三重激动剂肽。Retatrutide sodium salt 可用于研究2型糖尿病和肥胖症。
T78097L	Mazdutide acetate（2259884-03-0 free base） Mazdutide acetate（2259884-03-0 free base）,OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate	Glucagon Receptor	GPCR/G Protein
	Mazdutide acetate 是一种高效的胰高血糖素样肽 (GLP-1R) 与胰高血糖素受体 (GCGR) 的共激动剂，是一种胃泌酸调节素类似物。Mazdutide acetate可刺激小鼠胰岛的胰岛素分泌，可用于研究肥胖和 2 型糖尿病 (T2D) 。
T19850	Semaglutide 索玛鲁肽,司美格鲁肽,索马鲁肽	Glucagon Receptor	GPCR/G Protein
	Semaglutide 是人胰高血糖素样肽-1受体激动剂，是一种人胰高血糖素样肽-1 的长效类似物。它有用于 2 型糖尿病研究的潜力。
T11407	GLP-1 receptor agonist 2	Others	Others
	GLP-1 receptor agonist 2 is a glucagon-like peptide-1 receptor (GLP-1R) agonist.
T39820	Dapiglutide ZP7570
	Dapiglutide (ZP7570) is a long-acting dual agonist of glucagon-like peptide-1 receptor (GLP-1R) and glucagon-like peptide-2 receptor (GLP-2R) that holds potential for short bowel syndrome (SBS) research.
T12878	Semaglutide TFA (910463-68-2 free base) Semaglutide TFA	Glucagon Receptor	GPCR/G Protein
	Semaglutide TFA is a agonist of glucagon-like peptide-1 (GLP-1) receptor,with a potential for type 2 diabetes treatment.
T76330	Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide
	Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide 是一种带有生物素标签的Glucagon-like peptide-1-(7-36)，后者为一种具备提升胰岛素释放功能，从而表现出抗糖尿病活性的胃肠道肽。
T13091	Taspoglutide R1583,BIM51077,ITM077	Others	Others
	Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist(EC50 value of 0.06 nM),and for treatment of type 2 diabetes
TP1487	Glucagon-Like Peptide (GLP) II, human
	Glucagon-like peptide 2 (GLP-2) is a recently identified intestinal epithelium-specific growth factor that has been shown to reduce the severity of inflammatory disorders of the intestine in rodent models. Currently Glucagon-Like Peptide 2 is used as a po
T40374	Pal-Glu(OSu)-OH
	Pal-Glu(OSu)-OH is a side chain specific to Liraglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist employed in type 2 diabetes mellitus research.
T36428	PACAP-related Peptide (human) (trifluoroacetate salt)	PACAP	GPCR/G Protein
	PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in normal human pancreas and adrenal gland tissue and in some tumors that produce vasoactive intestinal peptide (VIP). PRP (1-29) is secreted by CHO-K1 cells that express human recombinant preproPACAP.
T75718	Dulaglutide
	Dulaglutide (LY2189265)，一种GLP-1受体激动剂，用于2型糖尿病的研究。
T81527	Pegloxenatide PEX 168
	Pegloxenatide，一种胰高血糖素样肽-1受体(GLP-1 RA)激动剂，主要用于2型糖尿病的研究。
T37435	PACAP-related Peptide (rat) (trifluoroacetate salt)	PACAP	GPCR/G Protein
	PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala. PRP is also expressed in vaginal, uterine cervica...
TP1340	Lixisenatide
	Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used in the treatment of type 2 diabetes mellitus (T2DM).It is an injectable diabetes medicine that helps control blood sugar levels.
T13091L	Taspoglutide acetate (275371-94-3 Free base)
	Taspoglutideacetate (275371-94-3 Free base) 是一种长效胰高血糖素样肽 1 (GLP-1) 受体激动剂，可用于有关 2 型糖尿病的研究。
T78097	Mazdutide IBI-362,LY-3305677,OXM-3
	Mazdutide (IBI-362; LY-3305677) 是一种具有安全性和耐受性的胃泌酸调节素类似物，用于肥胖和2型糖尿病(T2D)的研究。它同时作为胰高血糖素样肽(GLP-1R)和胰高血糖素受体(GCGR)的共激动剂，表现出长效作用。
T80079	Mazdutide TFA LY-3305677 TFA,IBI-362 TFA,OXM-3 TFA
	Mazdutide (IBI-362; LY-3305677) TFA 是一款GLP-1R与GCGR的共激动剂，同时是长效合成胃泌酸调节素类似物。该化合物安全性和耐受性良好，适用于肥胖与T2D研究。
T76006	Tirzepatide TFA Tirzepatide TFA(2023788-19-2 free base),LY3298176 TFA
	Tirzepatide TFA (LY3298176 TFA) 是葡萄糖依赖性胰岛素营养多肽(GIP)和胰高血糖素样肽-1(GLP-1)受体双重激动剂，有潜力用于 2 型糖尿病的研究。
T82923	Bamadutide SAR425899
	Bamadutide (SAR425899)是一种高效的GLP-1/GIP受体激动剂，主要通过增强β细胞功能和降低葡萄糖吸收速率，从而改善餐后血糖控制。该化合物适用于2型糖尿病的研究。
T75822	GLP-1(9-36)amide TFA
	GLP-1(9-36)amide TFA, 作为胰高血糖素样肽-1 (7-36)amide的主要代谢产物，是人胰腺GLP-1受体的拮抗剂。
T81025	Teduglutide TFA ALX-0600 TFA
	Teduglutide TFA 是一种具有耐受二肽基肽酶 IV 的胰高血糖素样肽 2 (GLP-2) 类似物，与肠道黏膜营养作用相关。它可用于研究短肠综合征 (SBS) 和克罗恩病 (CD)。
T36380	GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)
	GLP-1 amide is a peptide hormone cleaved from proglucagon in the pancreas.1,2 Mice lacking the glucagon receptor (Gcgr-/-) have approximately nine-fold higher levels of total GLP-1 amide, including GLP-1 (1-36) amide and truncated GLP-1 (7-36) amide , in pancreatic tissue compared to wild-type mice.2References1. Schjoldager, B.T., Mortensen, P.E., Christiansen, J., et al. GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans...
T76290	Exendin-4 (3-39)
	Exendin-4 (3-39) 是一种肽。Exendin-4 (3-39) 是 Exendin-4 的截断形式，缺少前两个氨基酸。Exendin-4 是一种有效的 GLP-1r 激动剂。Exendin-4 (3-39) 和 Exendin-4 可用于糖尿病和下丘脑-垂体-肾上腺 (HPA) 轴的研究。
T76291	Des His1, Glu8 Exendin-4
	Des His1, Glu8 Exendin-4 是一种高效的GLP-1-R（胰高血糖素样肽-1 受体）拮抗剂，主要通过调控胰岛素分泌和抑制葡萄糖生成来维持葡萄糖稳态。该化合物广泛应用于2型糖尿病及胃肠道相关研究领域。
T76056	Glepaglutide
	Glepaglutide (ZP1848)，一种长效的 GLP-2 类似物，是一种有效的GLP-2R 激动剂。Glepaglutide 可减少粪便排出量并增加肠道吸收。Glepaglutide 可减轻小肠炎症。Glepaglutide 可用于炎症性肠病 (IBD) 和克罗恩病的研究。
T76057	Glepaglutide acetate
	Glepaglutide (ZP1848) acetate，一种长效的 GLP-2 类似物，是一种有效的GLP-2R 激动剂。Glepaglutide acetate 可减少粪便排出量并增加肠道吸收。Glepaglutide acetate 可减轻小肠炎症。Glepaglutide acetate 可用于炎症性肠病 (IBD) 和克罗恩病的研究。
T73694	Albiglutide TFA
	Albiglutide TFA 是一种胰高血糖素样肽GLP-1模拟物，是长效的GLP-1受体激动剂。Albiglutide TFA 可显著降低糖化血红蛋白 (A1C)。Albiglutide TFA 可用于研究 2 型糖尿病 (T2D)。Albiglutide TFA 是由抗DPP-4的GLP-1二聚体与人白蛋白的基因融合产生的。
T83906	Tirzepatide sodium LY3298176
	Tirzepatide 是一种glucagon-like peptide 1 receptor (GLP-1R) 和 G protein-coupled receptor 119 (GPR119)的激动剂。它在表达人类GLP-1R或GPR119的HEK293细胞中诱导cAMP的产生（EC50s分别为6.54和1.01 nM）。Tirzepatide（100 nM）在表达人类GLP-1R或GPR119的HEK293细胞中诱导受体内化。在体内，Tirzepatide（每天10 nmol/kg）降低高脂饮食诱导的肥胖小鼠模型的体重、食物摄入量、血浆leptin、三酸甘油酯和free fatty acids (FFAs)水平、肝脏三酸甘油酯和血糖水平。它通过每三天给药50 nmol/kg的剂量，阻止A. alternata诱导的A. alternata挑战小鼠的支气管肺泡灌洗液（BALF）中嗜酸性粒细胞和淋巴细胞数量的增加。Tirzepatide（每三天50 nmol/kg）抑制由毒蕈碱受体激动剂methacholine (acetyl-β-methylcholine)导致的在糖尿病诱导的哮喘...

化合物

GLP-2(1-33)(human)

Cat.No: TP1157

Synonym: GLP-2 (human),Glucagon-like peptide 2 (human)

Semaglutide Acetate

Cat.No: T19850L

Synonym: 索玛鲁肽醋酸盐,Semaglutide Acetate(910463-68-2 Free base)

Target: Glucagon Receptor

Lixisenatide acetate (320367-13-3 free base)

Cat.No: TP1469

Synonym: Lixisenatide acetate

Target: Glucagon Receptor

Retatrutide sodium salt

Cat.No: T76279L1

Synonym: Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt

Target: Glucagon Receptor

Mazdutide acetate（2259884-03-0 free base）

Cat.No: T78097L

Synonym: Mazdutide acetate（2259884-03-0 free base）,OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate

Target: Glucagon Receptor

Cat.No: T19850

Synonym: 索玛鲁肽,司美格鲁肽,索马鲁肽

Target: Glucagon Receptor

GLP-1 receptor agonist 2

Cat.No: T11407

Target: Others

Cat.No: T39820

Synonym: ZP7570

Semaglutide TFA (910463-68-2 free base)

Cat.No: T12878

Synonym: Semaglutide TFA

Target: Glucagon Receptor

Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide

Cat.No: T76330

Cat.No: T13091

Synonym: R1583,BIM51077,ITM077

Target: Others

Glucagon-Like Peptide (GLP) II, human

Cat.No: TP1487

Pal-Glu(OSu)-OH

Cat.No: T40374

PACAP-related Peptide (human) (trifluoroacetate salt)

Cat.No: T36428

Target: PACAP

Cat.No: T75718

Cat.No: T81527

Synonym: PEX 168

PACAP-related Peptide (rat) (trifluoroacetate salt)

Cat.No: T37435

Target: PACAP

Cat.No: TP1340

Taspoglutide acetate (275371-94-3 Free base)

Cat.No: T13091L

Cat.No: T78097

Synonym: IBI-362,LY-3305677,OXM-3

Cat.No: T80079

Synonym: LY-3305677 TFA,IBI-362 TFA,OXM-3 TFA

Tirzepatide TFA

Cat.No: T76006

Synonym: Tirzepatide TFA(2023788-19-2 free base),LY3298176 TFA

Cat.No: T82923

Synonym: SAR425899

GLP-1(9-36)amide TFA

Cat.No: T75822

Teduglutide TFA

Cat.No: T81025

Synonym: ALX-0600 TFA

GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)

Cat.No: T36380

Exendin-4 (3-39)

Cat.No: T76290

Des His1, Glu8 Exendin-4

Cat.No: T76291

Cat.No: T76056

Glepaglutide acetate

Cat.No: T76057

Albiglutide TFA

Cat.No: T73694

Tirzepatide sodium

Cat.No: T83906

Synonym: LY3298176

Cat. No.	Product Name	Target	Signaling Pathways
T37526	2-Oleoylglycerol 2-Oleoyl Glycerol,2-OG,2-Monoolein	GPR	Endocrinology/Hormones; GPCR/G Protein
	2-Oleoylglycerol 是一种存在于棕榈仁、葵花籽和米糠中的脂质。2-Oleoylglycerol 可当作一种 GPR119 激动剂，具有神经保护作用，可诱导胰高血糖素样肽 1 (GLP-1) 分泌。2-Oleoylglycerol 可用于非酒精性脂肪性肝炎造模。

天然产物

2-Oleoylglycerol

Cat.No: T37526

Synonym: 2-Oleoyl Glycerol,2-OG,2-Monoolein

Target: GPR

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