Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23490 |
UBP310
UBP 310 |
Others; iGluR | Membrane transporter/Ion channel; Neuroscience; Others |
UBP310 (UBP 310) 是选择性GluR5拮抗剂,Kd 值为 130 nM。 | |||
T38659 |
mGluR5 modulator 1
|
||
mGluR5 modulator 1 is a compound that acts as a positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Its primary application lies in the field of schizophrenia and cognitive impairment research. | |||
T81801 |
mGluR5 antagonist-1
|
||
mGluR5 antagonist-1,一种高亲和力的mGluR5拮抗剂,其IC50为11.5 nM,表现出抗抑郁活性。 | |||
T27947L |
LY339434 HCl
LY339434 HCl(219566-62-8 Free base) |
GluR; NMDAR | Neuroscience |
LY339434 HCl是一种亲和力很低的GluR5红氨酸受体激动剂。LY339434 HCl 主要通过影响 N-甲基-D-天冬氨酸(NMDA)受体来快速的神经元死亡。 | |||
T27949 |
LY382884
LY-382884,LY 382884 |
GluR | Neuroscience |
LY382884 是一种具有选择性和有效性的 GLU(K5)受体拮抗剂,具有抗焦虑活性。LY382884可阻断阻断苔藓纤维LTP的诱导。 | |||
T0675 |
Topiramate
RWJ 17021,McN 4853,托吡酯 |
Potassium Channel; Calcium Channel; GABA Receptor; Sodium Channel; GluR; Carbonic Anhydrase; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Topiramate (RWJ 17021) 是一种GluR5受体拮抗剂,可通过增强GABAergic 活性,抑制kainate/AMPA 受体,抑制钠和钙通道的电压敏感,增加钾电导并抑制碳酸酐酶来产生抗癫痫作用,用于治疗部分性和全身性癫痫发作。 | |||
T10405 | ATPA | Others | Others |
ATPA is a selective glutamate receptor GluR5 activator (EC50s: 0.66, 1.4, 9.5, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S721T), GluR5(S741M), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V)). | |||
T22546 |
UBP316
ACET |
Others | Others |
GluR5-containing kainate receptor antagonist | |||
T27947 |
LY339434
LY 339434,LY-339434 |
||
LY339434 is a potent and selective agonist of the kainate receptor GluK1, GluR5. | |||
T13185 |
Topiramate D12
RWJ 17021 D12,McN 4853 D12 |
Others | Others |
Topiramate D12 is a deuterium labeled Topiramate. Topiramate is an agent of broad-spectrum antiepileptic. Topiramate is an antagonist of GluR5 receptor. | |||
T23488 |
UBP 296
|
Others | Others |
GluR5-subunit containing kainate receptor antagonist | |||
T61145 | Topiramate lithium | ||
Topiramate lithium (McN 4853) is a wide-ranging antiepileptic compound with GluR5 receptor antagonistic properties. Its mechanism of action involves enhancing GABAergic activity, inhibiting kainate/AMPA receptors, voltage-sensitive sodium and calcium channels, and increasing potassium conductance. Additionally, this compound inhibits carbonic anhydrase. [1][2][3] |