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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T12189	NBDHEX	Apoptosis; Glutathione Peroxidase; Autophagy	Apoptosis; Autophagy; Metabolism
	NBDHEX 是一种谷胱甘肽 S-转移酶 P1-1 抑制剂，也是晚期自噬抑制剂。它诱导肿瘤细胞凋亡，通过抑制 GST 的催化活性，避免抑制剂被特异性泵从细胞中排出，以及破坏 GSTP1-1和关键信号传导因子之间的相互作用，从而起到抗癌的作用。
T14042	4-P-PDOT 4-phenyl-2- propionamidotetralin	Melatonin Receptor; MT Receptor	GPCR/G Protein; Neuroscience
	4-P-PDOT (4-phenyl-2- propionamidotetralin) 是一种选择性和亲和性的褪黑激素受体拮抗剂，可显著抵消褪黑激素介导的抗氧化作用。它对MT2的选择性是 MT1 的 300 倍以上。
T36173	L-Glutathione, oxidized (sodium salt)
	Glutathione can occur in reduced (GSH), oxidized (GSSG), or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell. GSSG is the oxidized form of GSH . It can be reduced back to GSH through the NADPH-dependent enzyme glutathione reductase. GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications. The rat...
T80056	Glutathione Peroxidase GSH-Px,EC 1.11.1.9	Glutathione Peroxidase	Metabolism
	Glutathione Peroxidase (GSH-Px; EC 1.11.1.9)，是一种关键的抗氧化酶，能催化GSH与过氧化氢或脂质过氧化物反应，生成GSSG和H2O，从而减缓氧化应激。此酶在生化研究中具有重要应用。
T73422	CPT-Se4	Topoisomerase	DNA Damage/DNA Repair
	CPT-Se4为含硒前体活性分子的喜树碱(CPT)衍生物，对癌细胞具有较高杀伤力和抑制肿瘤生长效果。在降低GSH/GSSG比率和总硫醇的同时，CPT-Se4能够增加Hep G2细胞中的ROS水平，触发癌细胞凋亡。此化合物对HeLa、Hep G2、A549和SMMC-7721细胞系显示出显著的细胞毒性，IC50值范围为2.54-6.4 μM。
T73421	CPT-Se3	Topoisomerase	DNA Damage/DNA Repair
	CPT-Se3为含硒的喜树碱前体活性分子，其杀癌和抗肿瘤效力显著。它通过降低GSH/GSSG比率及总硫醇水平，增加Hep G2细胞中ROS含量，触发癌细胞凋亡。CPT-Se3对HeLa、Hep G2、A549及SMMC-7721细胞线具备显着细胞毒性，IC50值介于2.19-4.7 μM。
T36514	QD-394
	QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin ...

化合物

NBDHEX

Cat.No: T12189

Synonym:

Target: Apoptosis, Glutathione Peroxidase, Autophagy

4-P-PDOT

Cat.No: T14042

Synonym: 4-phenyl-2- propionamidotetralin

Target: Melatonin Receptor, MT Receptor

L-Glutathione, oxidized (sodium salt)

Cat.No: T36173

Synonym:

Target:

Glutathione Peroxidase

Cat.No: T80056

Synonym: GSH-Px,EC 1.11.1.9

Target: Glutathione Peroxidase

CPT-Se4

Cat.No: T73422

Synonym:

Target: Topoisomerase

CPT-Se3

Cat.No: T73421

Synonym:

Target: Topoisomerase

Cat. No.	Product Name	Target	Signaling Pathways
T1085L	Glutathione oxidized Bi(glutathion-S-yl),Oxidized glutathione,L-谷胱甘肽(氧化型),氧化型谷胱甘肽,L-Glutathione oxidized,Glutathione disulfide,L(-)-Glutathione,GSSG	Reactive Oxygen Species; Endogenous Metabolite; Glutathione reductase	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Glutathione oxidized (L(-)-Glutathione) 是氧化型谷胱甘肽，谷胱甘肽是细胞内一种主要的抗氧化剂和解毒剂。

天然产物

Glutathione oxidized

Cat.No: T1085L

Synonym: Bi(glutathion-S-yl),Oxidized glutathione,L-谷胱甘肽(氧化型),氧化型谷胱甘肽,L-Glutathione oxidized,Glutathione disulfide,L(-)-Glutathione,GSSG

Target: Reactive Oxygen Species, Endogenous Metabolite, Glutathione reductase

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