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Search Results for " gitr "

3

抑制剂 & 化合物

1

天然产物

20

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T28921	Tanogitran BIBT 986,BIBT986,BIBT-986
	Tanogitran, a coagulation factor Xa inhibitor, is used potentially for the treatment of septic shock.
T77138	Ragifilimab INCAGN-01876,INCAGN-1876,CM-701	TNF	Apoptosis
	Ragifilimab (INCAGN-1876)，一种针对糖皮质激素诱导的TNFR相关蛋白(GITR)的单克隆抗体激动剂，适用于晚期或转移性实体瘤的研究。
T82502	Efaprinermin alfa OMP-336B11
	Efaprinermin alfa (OMP-336B11)，一种人源化单克隆抗体，靶向TNFRSF18。该化合物为GITR配体-Fc融合蛋白。

化合物

Cat.No: T28921

Synonym: BIBT 986,BIBT986,BIBT-986

Cat.No: T77138

Synonym: INCAGN-01876,INCAGN-1876,CM-701

Target: TNF

Efaprinermin alfa

Cat.No: T82502

Synonym: OMP-336B11

Cat. No.	Product Name	Target	Signaling Pathways
T8294	Quercetagitrin 万寿菊苷,槲皮万寿菊素-7-O-Β-吡喃葡萄糖苷,Quercetagetin-7-O-glucoside	Others	Others
	Quercetagitrin (Quercetagetin-7-O-glucoside) 是分离自非洲万寿菊花 (Tagetes erecta) 中，具有抗炎作用。

天然产物

Cat.No: T8294

Synonym: 万寿菊苷,槲皮万寿菊素-7-O-Β-吡喃葡萄糖苷,Quercetagetin-7-O-glucoside

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00072	GITR/TNFRSF18 Protein, Human, Recombinant (His) AITR,GITR-D,tumor necrosis factor receptor superfam...	Human	HEK293
	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases...
TMPK-01260	GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His) TNFRSF18,GITR-D,AITR,CD357,GITR	Cynomolgus	HEK293
	GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
TMPY-05233	GITR/TNFRSF18 Protein, Human, Recombinant (His), Biotinylated GITR-D,CD357,AITR,GITR,tumor necrosis fact...	Human	HEK293
	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases...
TMPY-05253	GITR/TNFRSF18 Protein, Mouse, Recombinant (mFc) AITR,tumor necrosis factor receptor superfamily, member 18,<...	Mouse	HEK293
	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases...
TMPK-00132	GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His & Avi), Biotinylated GITR-D,CD357,AITR,GITR,TNFRSF18	Human	HEK293
	GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
TMPY-05602	GITR/TNFRSF18 Protein, Human, Recombinant (hFc & Avi), Biotinylated AITR,GITR,tumor necrosis factor receptor superfamil...	Human	HEK293
	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases...
TMPY-04265	GITR/TNFRSF18 Protein, Human, Recombinant (hFc) GITR-D,tumor necrosis factor receptor superfamily, ...	Human	HEK293
	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases...
TMPK-01086	GITR/TNFRSF18 Protein, Mouse, Recombinant (aa 22-153, His) TNFRSF18,AITR,GITR-D,CD357,GITR	Mouse	HEK293
	GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
TMPK-00133	GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His) GITR-D,AITR,GITR,CD357,TNFRSF18	Human	HEK293
	GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
TMPY-06411	GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated CD357,GITR-D,tumor necrosis factor receptor superfa...	Human	HEK293
	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases...
TMPY-06017	GITR/TNFRSF18 Protein, Mouse, Recombinant (His) Gitr,AITR,tumor necrosis factor receptor superfamil...	Mouse	HEK293
	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases...
TMPK-01064	GITR Ligand/TNFSF18 Protein, Mouse, Recombinant (hFc) GITRL,GITR Ligand,TL6,TNFSF18,AITRL	Mouse	HEK293
	Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept.
TMPK-00053	GITR Ligand/TNFSF18 Protein, Human, Recombinant (His & Flag) AITRL,TNFSF18,TL6,GITR Ligand,GITRL	Human	HEK293
	Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept.
TMPK-00054	GITR Ligand/TNFSF18 Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated TL6,GITR Ligand,TNFSF18,AITRL,GITRL	Human	HEK293
	Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept.
TMPJ-00110	GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His) Tnfrsf18,GITR-D,CD357,AITR,Tumor necrosis factor re...	Mouse	Human Cells
	Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and...
TMPY-05155	GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (His) tumor necrosis factor receptor superfamily, member 18	Cynomolgus	HEK293
	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases...
TMPY-03232	GITR/TNFRSF18 Protein, Rat, Recombinant (hFc) tumor necrosis factor receptor superfamily, member 18	Rat	HEK293
	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases...
TMPJ-00432	GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His) GITRL,TNFSF18,Activation-inducible TNF-related liga...	Cynomolgus	Human Cells
	TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation ...
TMPY-05292	GITRL Protein, Human, Recombinant (His) TL6,tumor necrosis factor (ligand) superfamily, member 18,h<...	Human	Baculovirus-Insect Cells
	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Targ...
TMPY-05163	GITRL Protein, Human, Recombinant (mFc) TL6,GITRL,tumor necrosis factor (ligand) superfamil...	Human	HEK293
	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Targ...

重组蛋白

GITR/TNFRSF18 Protein, Human, Recombinant (His)

Cat.No: TMPY-00072

Species: Human

Expression System: HEK293

GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His)

Cat.No: TMPK-01260

Species: Cynomolgus

Expression System: HEK293

GITR/TNFRSF18 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05233

Species: Human

Expression System: HEK293

GITR/TNFRSF18 Protein, Mouse, Recombinant (mFc)

Cat.No: TMPY-05253

Species: Mouse

Expression System: HEK293

GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His & Avi), Biotinylated

Cat.No: TMPK-00132

Species: Human

Expression System: HEK293

GITR/TNFRSF18 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-05602

Species: Human

Expression System: HEK293

GITR/TNFRSF18 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04265

Species: Human

Expression System: HEK293

GITR/TNFRSF18 Protein, Mouse, Recombinant (aa 22-153, His)

Cat.No: TMPK-01086

Species: Mouse

Expression System: HEK293

GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His)

Cat.No: TMPK-00133

Species: Human

Expression System: HEK293

GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06411

Species: Human

Expression System: HEK293

GITR/TNFRSF18 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06017

Species: Mouse

Expression System: HEK293

GITR Ligand/TNFSF18 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01064

Species: Mouse

Expression System: HEK293

GITR Ligand/TNFSF18 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPK-00053

Species: Human

Expression System: HEK293

GITR Ligand/TNFSF18 Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated

Cat.No: TMPK-00054

Species: Human

Expression System: HEK293

GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His)

Cat.No: TMPJ-00110

Species: Mouse

Expression System: Human Cells

GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-05155

Species: Cynomolgus

Expression System: HEK293

GITR/TNFRSF18 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03232

Species: Rat

Expression System: HEK293

GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00432

Species: Cynomolgus

Expression System: Human Cells

GITRL Protein, Human, Recombinant (His)

Cat.No: TMPY-05292

Species: Human

Expression System: Baculovirus-Insect Cells

GITRL Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05163

Species: Human

Expression System: HEK293

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