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Cat. No. Product Name Target Signaling Pathways
T11344 G150

DNA; cGAS DNA Damage/DNA Repair; Immunology/Inflammation
G150 是高选择性h-cGAS 抑制剂,IC50值为 10.2 nM,用于抑制 dsDNA 引发的干扰素表达。
T8752 BAR 501 impurity

GPCR19 GPCR/G Protein
BAR 501 impurity 在 BAR501 制剂中发现的一种杂质,可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。
T36949 Niaprazine

5-HT Receptor; Adrenergic Receptor; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Neuroscience
Niaprazine 是有效的组胺 H1 受体拮抗剂,具有抗组胺和抗血清素活性。Niaprazine 在睡眠障碍方面有研究的价值。
T36729 Urotensin II (goby) (trifluoroacetate salt)

Urotensin II is a peptide vasoconstrictor and agonist of the urotensin (UT) receptor (Ki= 2.06 nM for the human recombinant receptor expressed in HEK293 cells).1It stimulates intracellular calcium mobilization in HEK293 cells expressing human and rat UT (EC50s = 0.47 and 0.78 nM, respectively) but decreases intracellular calcium concentration in goby (G. mirabilis) enterocytes when used at a concentration of 500 nM.2Urotensin II (20 mU/ml) stimulates active sodium and chloride absorption across ...
T37096 Sepimostat dimethanesulfonate

Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 μM[1]. Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect[1]. ...

化合物

G150
Cat.No: T11344
Synonym:
Target: DNA, cGAS
BAR 501 impurity
Cat.No: T8752
Synonym:
Target: GPCR19
Niaprazine
Cat.No: T36949
Synonym:
Target: 5-HT Receptor, Adrenergic Receptor, Histamine Receptor
Urotensin II (goby) (trifluoroacetate salt)
Cat.No: T36729
Synonym:
Target:
Sepimostat dimethanesulfonate
Cat.No: T37096
Synonym:
Target:
TargetMol Loading
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