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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39308 |
Boc-Asp(OMe)-fluoromethyl ketone
Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK |
Caspase | Apoptosis; Proteases/Proteasome |
Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) 是广谱的 caspase 抑制剂,可抑制 Fas 介导的吞噬作用和氧化破裂抑制,但对 IL-8 的趋化活性无影响。 | |||
T17018 |
TCPOBOP
|
BCL | Apoptosis |
TCPOBOP 是一种组成型雄烷受体激动剂,可诱导强大的肝细胞增殖和肝肿大。它通过改变 Bcl-2 蛋白来减少 Fas 诱导的小鼠肝损伤。 | |||
T78586 | Ac-IETD-CHO | Apoptosis | Apoptosis |
Ac-IETD-CHO是一种针对granzyme B和caspase 8的有效可逆抑制剂,能够阻止Fas介导的(Apoptosis)、出血和肝衰竭,并且能够抑制细胞毒性T淋巴细胞引发的细胞死亡。 | |||
T64171 | LXR antagonist 2 | ||
LXR antagonist 2 (compound 10rr) 是一种有效的 LXR (肝 X 受体) 反向激动剂,能够作用于 LXRβ (IC50: 0.36 μM) 和 LXRα (IC50: 2.25 μM)。 LXR antagonist 2 是一种脂肪生成抑制剂,能够下调 LXR 靶基因 SREBP-1c、ACC、FAS 和 SCD-1。LXR antagonist 2 对 Triton WR-1339 诱导的高脂血症小鼠表现出降脂活性。 | |||
T36130 |
22(S)-hydroxy Cholesterol
22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol |
||
22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2854 |
Phillyrin
Forsythin,连翘苷 |
P450; Influenza Virus; AMPK | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Phillyrin (Forsythin) 是从连翘中分离出来的一种天然产物,具有抗甲型流感病毒的活性,以及抗菌和消炎作用。 | |||
T13815 |
Penicillic acid
|
Apoptosis; Caspase; Antibacterial; Antibiotic | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Penicillic acid,一种由多种Aspergillus和Penicillium物种合成的polyketide mycotoxin,通过阻碍caspase-8的自我处理作用,抑制Fas ligand引发的apoptosis。此外,体外研究表明,Penicillic acid在rat alveolar macrophages中显示出cytotoxic特性。 |