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Targets Recommended: Dehydrogenase Sirtuin HDAC p53 Autophagy

6

抑制剂 & 化合物

2

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T8480 Tenovin-6 Hydrochloride

Dehydrogenase; Sirtuin; HDAC; p53; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
Tenovin-6 Hydrochloride 是 Tenovin-1 的类似物,能抑制二氢乳清酸脱氢酶。它是一种 p53转录活性的激活剂,抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性,IC50分别为 21 μM、10 μM 和 67 μM。
T1919 Tenovin-1

Tenovin 1

Mdm2; Dehydrogenase; Sirtuin; p53; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
Tenovin-1 抑制 SirT1 和 SirT2 的蛋白质去乙酰化活性,并防止 MDM2 介导的 p53 降解,这涉及泛素化。它具有癌症的研究潜力。
T1873 Tenovin-3

Tenovin3

Sirtuin Chromatin/Epigenetic; DNA Damage/DNA Repair
Tenovin-3 是一种 p53激活剂。
T4642 Tenovin-2

Others Others
Tenovin-2 在生命科学相关研究中具有广泛的应用。
T1818 Tenovin-6

Tenovin 6

Dehydrogenase; Sirtuin; Autophagy Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
Tenovin-6 是 Tenovin-1 的类似物,能抑制二氢乳清酸脱氢酶。它也抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性,IC50分别为 21 μM、10 μM 和 67 μM。它是一种 p53转录活性的激活剂。
T26259 Tenovin-D3

TenovinD3

Tenovin-D3 is a sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner.

化合物

Tenovin-6 Hydrochloride
Cat.No: T8480
Synonym:
Target: Dehydrogenase, Sirtuin, HDAC, p53, Autophagy
Tenovin-1
Cat.No: T1919
Synonym: Tenovin 1
Target: Mdm2, Dehydrogenase, Sirtuin, p53, Autophagy
Tenovin-3
Cat.No: T1873
Synonym: Tenovin3
Target: Sirtuin
Tenovin-2
Cat.No: T4642
Synonym:
Target: Others
Tenovin-6
Cat.No: T1818
Synonym: Tenovin 6
Target: Dehydrogenase, Sirtuin, Autophagy
Tenovin-D3
Cat.No: T26259
Synonym: TenovinD3
Target:
Cat. No. Product Name Species Expression System
TMPJ-00100 Artemin Protein, Human, Recombinant

ARTN,Artemin,EVN,Enovin,Neublastin

Human E. coli
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I...
TMPK-00109 Artemin Protein, Human, Recombinant (hFc)

ARTNE,ARTN,Neublastin,Enovin,Artemin,NBN,EVN

Human HEK293 Cells
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons.

重组蛋白

Artemin Protein, Human, Recombinant
Cat.No: TMPJ-00100
Species: Human
Expression System: E. coli
Artemin Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00109
Species: Human
Expression System: HEK293 Cells
TargetMol Loading
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