Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6488 |
Epinastine hydrochloride
Alesion,Epinastine HCl,WAL-801CL HCl,依匹斯汀盐酸盐,Elestat |
5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Epinastine hydrochloride (WAL-801CL HCl) 是抗组胺剂和肥大细胞稳定剂,是一种可口服的选择性组胺 H1 受体拮抗剂,可抑制 IL-8 释放,具有抗过敏作用。 | |||
T3107 |
Alvelestat
AZD9668,Avelestat |
Others; Serine Protease | Others; Proteases/Proteasome |
Alvelestat (AZD9668) 是一种口服活性,亲和性和选择性的中性粒细胞弹性蛋白酶 (NE) 抑制剂,pIC50=7.9 nM,Ki=为 9.4 nM,Kd=9.5 nM。 | |||
T20762 |
Sivelestat sodium tetrahydrate
ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046 |
Serine Protease | Proteases/Proteasome |
Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂,其 IC50 值为 44 nM, Ki 值为 200 nM。Sivelestat (EI546) sodium tetrahydrate 有潜力用于 COVID-19的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。 | |||
T6986 |
Sivelestat
ONO5046,EI546,西维来司他,LY544349 |
Others; SARS-CoV; Serine Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Sivelestat (ONO5046) 是一种选择性的中性粒细胞弹性蛋白酶抑制剂,其 IC50值为 44 nM,Ki 值为 200 nM。它有潜力研究 COVID-19 的急性肺损伤、急性呼吸窘迫综合征或弥散性血管内凝血。 | |||
T76216 |
Lonodelestat TFA
|
||
Lonodelestat TFA (POL6014 TFA) 是一种有效的、口服活性的、选择性的肽类hNE抑制剂,展现了治疗囊性纤维化(CF)的潜力。 | |||
T73657 |
Tiprelestat
|
||
Tiprelestat为有效的人类中性粒细胞弹性蛋白酶(elastase)抑制剂,展现抗菌及抗炎活性,适用于炎症/免疫疾病研究。 | |||
T3107L | Alvelestat tosylate | ||
Alvelestat can inhibit neutrophil elastase (NE), which acts an important role in NET formation. | |||
T21414 |
Sivelestat sodium
ONO 5046,LY-544349,Sivelestat sodium salt,ONO-5046,ONO5046,西维来司钠,LY544349,LY 544349 |
||
Sivelestat, an inhibitor of human neutrophil elastase, is used in the treatment of acute respiratory failure. Preliminary studies show Sivelestat may improve neuropathic pain. | |||
T31877 |
Freselestat
ONO-PO 736,ONO-6818,ONO 6818,ONO6818 |
||
Freselestat (ONO-6818) is a potent neutrophil elastase inhibitor that significantly reduces the production of interleukin 8 and C5B-9. Freselestat reduces inflammatory mediators during simulated cardiopulmonary bypass. | |||
T41043 |
Lonodelestat
POL6014 |
||
Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). | |||
T62846 | Freselestat quarterhydrate | ||
Freselestat quarterhydrate (ONO-6818 quarterhydrate) 是一种有效的、口服具有活力的嗜中性粒细胞弹性蛋白酶 (neutrophil elastase) 抑制剂 (Ki: 12.2 nM)。Freselestat quarterhydrate 对其他蛋白酶(例如胰蛋白酶,蛋白酶3,胰弹性蛋白酶,凝血酶,纤溶酶,胶原酶,组织蛋白酶G 和鼠巨噬细胞弹性蛋白酶)的活性低 100 倍以上,表现出有效的抗炎作用。 |