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Search Results for " epha2 "

13

抑制剂 & 化合物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T74611	EphA2 agonist 1
	EphA2agonist 1 (Compound 7bg) 是一种有效的EphA2receptor 激动剂。EphA2agonist 1 对EphA2过表达的胶质瘤细胞具有很强的活性和选择性，并能刺激EphA2磷酸化。
T72765	EphA2 agonist 2
	EphA2agonist 2 (Lead compound) 为一种选择性EphA2激动剂，展现出抗肿瘤活性，并能透过血脑屏障。
T19487	NVP-BHG712 isomer	Ephrin Receptor	Tyrosine Kinase/Adaptors
	NVP-BHG712 isomer 是一种 NVP-BHG712 的位置异构体，能够与EPHA2和EPHB4显示保守非键结合。
T73368	UniPR505	Ephrin Receptor	Tyrosine Kinase/Adaptors
	UniPR505 是一种有效的 EphA2 拮抗剂（IC50：0.95 µM），是一种具有抗血管生成作用的新型 3α-氨基甲酰氧基衍生物。
T6479	Dovitinib lactate hydrate Dovitinib (TKI258) Lactate,多韦替尼,Dovitinib Lactate,TKI258	VEGFR; FGFR; FLT; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Dovitinib lactate hydrate (TKI258) 是一种多靶点的酪氨酸激酶抑制剂，抑制 FLT3，c-Kit，FGFR1/3，VEGFR1/2/3和 PDGFRα/β的 IC50值分别为 1，2，8/9，10/13/8，27/210 nM。
T6289	Dovitinib TKI258,多韦替尼,CHIR-258,度维替尼	VEGFR; FGFR; FLT; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Dovitinib (CHIR-258) 是一种口服有效的、多靶点的酪氨酸激酶 (RTK) 抑制剂，具有抗肿瘤作用。
T80897	UniPR1447	Ephrin Receptor	Tyrosine Kinase/Adaptors
	UniPR1447 是一种双重EphA2和EphB2拮抗剂，其对EphA2−ephrin-A1结合的IC50为6.6 μM。
T76375	Targefrin
	Targefrin 是一种有效的靶向 EphA2的试剂，作为拮抗剂发挥作用。Targefrin 结合 EphA2- LBD 的解离常数为 21 nM，IC50值为10.8 nM。Targefrin 在几种胰腺癌细胞系中诱导细胞受体内化和降解。
T83667	A11 TFA CPP-EYVQTVKSSKG
	A11是一种细胞穿透肽，由HIV-1 Tat蛋白质转导域与对应于脂联素A1 N末端第20至30残基的11氨基酸肽连接而成。它减少脂联素A1与Eph受体酪氨酸激酶A2(EphA2)的结合，并在HK1鼻咽癌(NPC)细胞中增加EphA2的泛素化。A11（10 µM）抑制HK1和5-8F NPC细胞的增殖、迁移和侵袭。在体内，A11减少5-8F和HK1 NPC小鼠异种移植模型中的肿瘤体积。
T80896	UniPR1449	Ephrin Receptor	Tyrosine Kinase/Adaptors
	UniPR1449为EphA2受体拮抗剂，具有KD值约为3.8±2.4 μM，对癌症具有关键影响。
T74647	BT5528
	BT5528 是一种双环肽毒素结合物，一种EphA2激活剂。BT5528 由双环肽和AuristatinE 组成，是 BCY6099 的衍生物。BT5528 在大鼠模型中显示出强大的抗肿瘤活性，不导致出血或引起凝血毒性。
T6193	Dovitinib Dilactic Acid Dovitinib (TKI-258) Dilactic Acid,TKI258 Dilactic acid	VEGFR; FGFR; FLT; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Dovitinib Dilactic Acid (Dovitinib(TKI-258) Dilactic Acid) 是 Dovitinib 的双乳酸，是一种多靶点 RTK 抑制剂，主要用于 III 类 (FLT3/c-Kit)，IC50 为 1 nM/2 nM，对 IV 类 (FGFR1/ 3) 和 V 类 (VEGFR1-4) RTK，IC50 为 8-13 nM，对 InsR、EGFR、c-Met、EphA2、Tie2、IGFR1 和 HER2 的效力较低。
T14928	Agerafenib hydrochloride RXDX-105 hydrochloride,CEP-32496 (hydrochloride)	c-RET; c-Kit	Apoptosis; Tyrosine Kinase/Adaptors
	Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).

化合物

EphA2 agonist 1

Cat.No: T74611

EphA2 agonist 2

Cat.No: T72765

NVP-BHG712 isomer

Cat.No: T19487

Target: Ephrin Receptor

Cat.No: T73368

Target: Ephrin Receptor

Dovitinib lactate hydrate

Cat.No: T6479

Synonym: Dovitinib (TKI258) Lactate,多韦替尼,Dovitinib Lactate,TKI258

Target: VEGFR, FGFR, FLT, PDGFR, c-Kit

Cat.No: T6289

Synonym: TKI258,多韦替尼,CHIR-258,度维替尼

Target: VEGFR, FGFR, FLT, PDGFR, c-Kit

Cat.No: T80897

Target: Ephrin Receptor

Cat.No: T76375

Cat.No: T83667

Synonym: CPP-EYVQTVKSSKG

Cat.No: T80896

Target: Ephrin Receptor

Cat.No: T74647

Dovitinib Dilactic Acid

Cat.No: T6193

Synonym: Dovitinib (TKI-258) Dilactic Acid,TKI258 Dilactic acid

Target: VEGFR, FGFR, FLT, c-Kit

Agerafenib hydrochloride

Cat.No: T14928

Synonym: RXDX-105 hydrochloride,CEP-32496 (hydrochloride)

Target: c-RET, c-Kit

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00980	EPhA2 Protein, Cynomolgus, Recombinant (hFc) EC:2.7.10.1,Ephrin type-A receptor 2,E...	Cynomolgus	HEK293 Cells
	Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis; therefore, it is important to understand how EPHA2 gene (EPHA2) expression is regulated. EPhA2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 83.1 kDa and the accession number is Q1KL86.
TMPK-00979	EPhA2 Protein, Cynomolgus, Recombinant (His & Avi) EPHA2,EC:2.7.10.1,Ephrin type-A r...	Cynomolgus	HEK293 Cells
	Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis; therefore, it is important to understand how EPHA2 gene (EPHA2) expression is regulated. EPhA2 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 59.2 kDa and the accession number is Q1KL86.
TMPY-05588	EphA2 Protein, Human, Recombinant (His & Avi), Biotinylated ECK,CTPP1,EPH receptor A2,ARCC2,CTRCT6,CTP...	Human	HEK293 Cells
	EphA2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 59.4 kDa and the accession number is A0A024QZA8.
TMPY-06635	EphA2 Protein, Mouse, Recombinant Myk2,Sek2,Sek-2,Eck,EPH receptor ...	Mouse	HEK293 Cells
	EphA2 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 57.03 kDa and the accession number is NP_034269.2.
TMPY-03552	EphA2 Protein, Human, Recombinant (His) CTPA,EPH receptor A2,ECK,CTRCT6,CTPP1,ARCC2	Human	HEK293 Cells
	EphA2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is P29317.
TMPY-01777	EphA2 Protein, Mouse, Recombinant (His) Eck,Sek-2,AW545284,Myk2,EPH recep...	Mouse	HEK293 Cells
	EphA2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58 kDa and the accession number is Q03145.
TMPY-06769	EphA2 Protein, Human, Recombinant (hFc) EPH receptor A2,ARCC2,CTPA,CTPP1,CTRCT6,EC...	Human	HEK293 Cells
	EphA2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.91 kDa and the accession number is P29317.
TMPY-06812	EphA2 Protein, Mouse, Recombinant (His & Avi), Biotinylated Eck,AW545284,EPH receptor A2,Sek-2	Mouse	HEK293 Cells
	EphA2 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 60 kDa and the accession number is NP_034269.2.
TMPY-04427	EphA2 Protein, Human, Recombinant (aa 585-976, His & GST) ARCC2,EPH receptor A2,CTPA,ECK,CTPP1,CTRCT...	Human	Baculovirus Insect Cells
	EphA2 Protein, Human, Recombinant (aa 585-976, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 72.1 kDa and the accession number is P29317.
TMPJ-00114	EFNA3 Protein, Mouse, Recombinant (hFc) EFL2,LERK-3,EFNA3,Ephrin-A3,EHK1-L,EPLG3,EFL-2<...	Mouse	HEK293 Cells
	Ephrins-A3 belongs the Ephrins ligand family which involved in a variety of biological processes, especially in the nervous system and in erythropoiesis. It is shown that Ephrin-A3 is expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes. Ephrin-A3 has a GPI anchor following the extracellular sequence and a signal sequence of 22 amino acids. Ephrin-A3 can bind EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8 and EphB1. Futhe...
TMPJ-00085	EFNA4 Protein, Human, Recombinant (hFc & His) LERK-4,LERK4,EPH-Related Receptor Tyrosine Kinase Ligand 4,E...	Human	HEK293 Cells
	Ephrin-A4 is a member of the ephrin ligand family which binds members of the Eph receptor family. All ligands share a conserved extracellular sequence, which most likely corresponds to the receptor binding domain. Ephrin-A4 consists of approximately 125 amino acids and includes four invariant cysteines, It has been shown to bind EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, and EphB1. Ephrin-A4 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional s...
TMPJ-00546	EFNA1 Protein, Human, Recombinant (hFc) TNFAIP4,LERK1,Tumor Necrosis Factor α-Induced Protein 4,Imme...	Human	HEK293 Cells
	Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the...
TMPJ-00088	EFNA1 Protein, Mouse, Recombinant (hFc & His) Epgl1,Epl1,Immediate early response protein B61,Lerk1,EPH-re...	Mouse	HEK293 Cells
	Ephrin-A1 is a cell membrane protein and contains 1 ephrin RBD (ephrin receptor-binding) domain. EFNA1 belongs to the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membran...

重组蛋白

EPhA2 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPK-00980

Species: Cynomolgus

Expression System: HEK293 Cells

EPhA2 Protein, Cynomolgus, Recombinant (His & Avi)

Cat.No: TMPK-00979

Species: Cynomolgus

Expression System: HEK293 Cells

EphA2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05588

Species: Human

Expression System: HEK293 Cells

EphA2 Protein, Mouse, Recombinant

Cat.No: TMPY-06635

Species: Mouse

Expression System: HEK293 Cells

EphA2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03552

Species: Human

Expression System: HEK293 Cells

EphA2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01777

Species: Mouse

Expression System: HEK293 Cells

EphA2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-06769

Species: Human

Expression System: HEK293 Cells

EphA2 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06812

Species: Mouse

Expression System: HEK293 Cells

EphA2 Protein, Human, Recombinant (aa 585-976, His & GST)

Cat.No: TMPY-04427

Species: Human

Expression System: Baculovirus Insect Cells

EFNA3 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00114

Species: Mouse

Expression System: HEK293 Cells

EFNA4 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00085

Species: Human

Expression System: HEK293 Cells

EFNA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00546

Species: Human

Expression System: HEK293 Cells

EFNA1 Protein, Mouse, Recombinant (hFc & His)

Cat.No: TMPJ-00088

Species: Mouse

Expression System: HEK293 Cells

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