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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T80383	EP3
	EP3是一种具有抗细菌和抗真菌活性的抗菌肽。该化合物对E. gallinarum、P. pyocyanea、A. baumanii、K. terrigena展示出MIC值为11.4 μg/mL的抑制效果。EP3也显示了对癌细胞的抗肿瘤作用，并能诱导细胞凋亡(apoptosis)。
T77630	EP3 antagonist 4	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP3 antagonist 4 是一种 EP3 拮抗剂，对 hEP 有抑制作用， Ki 值为 2 nM。EP3 antagonist 4 在大鼠完整 PK 研究中显示出较低的体内清除率、高口服 AUC 和良好的生物利用度。EP3 antagonist 4 可用于研究糖尿病和细胞功能障碍。
T61357	EP3 antagonist 3
	EP3 antagonist 3 (compound 2) is a highly effective and specific antagonist of the EP3 receptor. It displays significant oral bioavailability and exhibits a strong pKi value of 8.3. Furthermore, EP3 antagonist 3 possesses excellent pharmacokinetic characteristics, making it a suitable candidate for experimental investigations involving overactive bladder (OAB) research [1].
T5841	Travoprost 曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Travoprost (Fluprostenol isopropyl ester) 是一种异丙基酯前药，是一种高亲和力的，选择性的 FP 前列腺素全受体激动剂。它能够降低眼压，有潜力应用于青光眼和眼高压。
T7264	CBP/EP300-IN-1	Epigenetic Reader Domain	Chromatin/Epigenetic
	CBP/EP300-IN-1是一种 CBP/EP300 溴结构域抑制剂。
TP1539	AtPep3
	AtPep3 is a hormone-like peptide that plays a role in the salinity stress tolerance of plants.
TP1614	AtPep3 TFA (902781-14-0 free base) AtPep3 TFA
	AtPep3 TFA is a hormone-like peptide that plays a role in the salinity stress tolerance of plants.
T73576	EP39
	EP39 是一种有效的HIV-1成熟抑制剂。EP39 与 Gag 的 SP1 结构域相互作用。EP39 通过与 SP1 结构域的 QVT 基序结合来降低 CA-SP1 连接的动力学，并通过稳定瞬态 α 螺旋结构来扰乱 SP1 结构域两侧的自然螺旋平衡。EP39 通过阻止HIV-1的成熟而起作用，从而阻断其感染性。
T82942	AtPep3 TFA
	AtPep3 TFA 为一种具激素特性的肽类化合物，能够提升植物对盐分的耐受能力，并能防止盐分诱导下幼苗叶绿素发生漂白现象。
T73921	Ep300/CREBBP-IN-2
	Ep300/CREBBP-IN-2 (Example 73) 是一种有效的和具有口服活性的Ep300和CREBBP 抑制剂，IC50分别为 0.052 μM 和 0.148 μM。Ep300/CREBBP-IN-2 可用于癌症研究。
T73922	Ep300/CREBBP-IN-3
	Ep300/CREBBP-IN-3 (Example 61) 是一种有效的Ep300和CREBBP 抑制剂，IC50分别为 0.056 μM 和 0.095 μM。Ep300/CREBBP-IN-3 可用于癌症研究。
T73920	Ep300/CREBBP-IN-8
	Ep300/CREBBP-IN-8 (Example 37) 是一种有效的和具有口服活性的 Ep300和CREBBP 抑制剂，IC50分别为 0.014 μM 和 0.018 μM。Ep300/CREBBP-IN-8 可用于癌症研究。
T73923	Ep300/CREBBP-IN-4
	Ep300/CREBBP-IN-4 (Example 56) 是一种有效的Ep300和CREBBP 抑制剂，IC50分别为 0.024 μM 和 0.064 μM。Ep300/CREBBP-IN-4 可用于癌症研究。
T15108	DG-041	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	DG-041 是高亲和力，选择性的，有效的 EP3受体拮抗剂，在结合和 FLIPR 试验中，IC50分别为 4.6 nM 和 8.1 nM。DG-041通过抑制 PGE2促进血小板聚集。DG-041具有血脑屏障渗透性。
T14148	AH 6809	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	AH 6809 是 EP 和 DP 受体的拮抗剂，对小鼠 EP2受体的 Ki 值为 350 nM，对克隆的人类 EP1，EP2，EP3-III 和 DP 受体的 Ki 值分别为 1217、1150、1597 和 1415 nM。
T11211	EP4 receptor antagonist 1	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP4 receptor antagonist 1 是一种有效的特异性前列腺素 EP4受体拮抗剂，对人和小鼠 EP4受体的 IC50分别为6.1 nM 和16.2 nM。 EP4 receptor antagonist 1 可用于癌症免疫治疗的研究。
T14975	CJ-42794 CJ-042794	Others	Others
	CJ-42794 (CJ-042794)是前列腺素受体 EP4的选择性拮抗剂, 抑制[3H]-PGE2与 EP4受体结合的平均 pKi 为8.5, 对 EP4选择性比 EP1, EP2和 EP3高200多倍。
T63349	Treprostinil diethanolamine UT-15C	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Treprostinil diethanolamine (UT-15C) 是EP2、DP1和IP 的有效激动剂，对EP2、DP1、IP、EP1、EP4、EP3 和 FPKi 的值分别为 3.6、4.4、32.1、212、826、2505 和 4680 nM。Treprostinil diethanolamine 能够促使 cAMP 的上调，进而维持血管系统内的稳态，并造成人肺动脉的血管扩张。
T3306	PF-04418948 PF 04418948,PF04418948	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	PF-04418948 是一种可口服的，选择性的前列腺素EP2受体拮抗剂，IC50为16 nM。
T5482	TG4-155	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	TG4-155 是一种脑渗透性 EP2 拮抗剂，对 EP2 和 DP1 具有低纳摩尔的拮抗活性。它作用于 EP2 的 KB 为 2.4 nM，比对 DP1 受体的选择性高 14 倍，比对 EP1、EP3、EP4 和 IP 的选择性比高 550-4750 倍。
T70042	PF-06748962
	PF-06748962 is a potent and selective lactam-based prostaglandin EP3 receptor antagonist.
T28252	ONO-AE-248
	ONO-AE-248 is a selective agonist of EP3 receptor.
T15689	L-798106 CM9,GW671021	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	L-798106 is a highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM). It also has micromolar activities at EP4, EP1, and EP2 receptors (Ki: 916 nM, >5000 nM, and >5000 nM at EP4, EP1, and EP2, respectively).
T23404	Sulprostone	Others	Others
	EP3 and EP1 receptor agonist
T15642	KAG-308	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing,
T37996	17-phenyl trinor Prostaglandin E2 ethyl amide 17-phenyl trinor Prostaglandin E2 ethyl amide
	17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to inc...
T37778	19(R)-hydroxy Prostaglandin E1 19(R)-hydroxy Prostaglandin E1
	19(R)-hydroxy Prostaglandin E1 是 EP1 和 EP3 受体亚型的激动剂，并对平滑肌表现出收缩活性，也是灵长类动物精液中的主要前列腺素。
T72513	SC 51089 free base
	SC 51089 free base 是一种选择性的前列腺素受体EP1拮抗剂，对EP1，TP，EP3和FP 受体的Ki 值分别为 1.3，11.2，17.5 和 61.1 μM。SC 51089 free base 具有神经保护活性。
T26925	Butaprost Butaprostum,TR-4979,(R)-Butaprost
	Butaprost is a chemical compound that functions as a selective agonist for the prostaglandin E receptor (EP2). It exhibits an EC50 of 33 nM and a Ki of 2.4 μM when interacting with the murine EP2 receptor. However, Butaprost demonstrates lower activity against murine EP1, EP3, and EP4 receptors. Furthermore, it effectively attenuates fibrosis by inhibiting the TGF-β/Smad2 signaling pathway [1] [2] [3].
T29907	Alprostadil sodium PGE1 sodium salt,Prostaglandin E1 sodium
	Alprostadil sodium 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。
T36080	Rivenprost ONO-4819
	Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively). It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.[1][2][3][4][5] Rivenprost has also been used to support wound healing.[6]
T5150	Treprostinil LRX-15,曲前列环素,Orenitram,曲前列尼尔,Remodulin	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Treprostinil (Orenitram) 是有效的 DP1、IP 和 EP2 激动剂，EC50分别为0.6、1.9 和 6.2 nM。
T23331	SC 51089 SC 51089 free base	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	SC 51089 是一种选择性的前列腺素受体 PGE2 拮抗剂，对前列腺素受体亚型具有选择性，具有抗伤害活性，可改善亨廷顿病 R6/1 小鼠模型中的运动缺陷并挽救记忆力下降。
T4981	Anisotropine Methylbromide	Prostaglandin Receptor; AChR	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Anisotropine Methylbromide 是一种抗胆碱能药物，已用于缓解胃肠道痉挛和抑制胃酸分泌。
TQ0290	ONO-AE3-208 AE 3-208	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	ONO-AE3-208 (AE 3-208) 是一种 EP4 拮抗剂，可抑制前列腺癌的细胞迁移、侵袭和转移。
T37441	KMN-80
	The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis. KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE1 that acts as a selective and potent agonist of EP4 with an IC50 value of 3 nM (IC50 = 1.4 μM for EP3 and > 10 μM for all other pro...
T40738	CAY10580 CAY10580
	CAY10580 is a potent and selective prostaglandin EP 4 receptor agonist ( K i =35 nM).
T20142	Tafluprost acid UNII-WTV8EPZ396
	Tafluprost acid is a selective agonist at the prostaglandin F receptor.
T15828	L 888607	Others	Others
	L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM).

化合物

Cat.No: T80383

EP3 antagonist 4

Cat.No: T77630

Target: Prostaglandin Receptor

EP3 antagonist 3

Cat.No: T61357

Cat.No: T5841

Synonym: 曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221

Target: Prostaglandin Receptor

Cat.No: T7264

Target: Epigenetic Reader Domain

Cat.No: TP1539

AtPep3 TFA (902781-14-0 free base)

Cat.No: TP1614

Synonym: AtPep3 TFA

Cat.No: T73576

Cat.No: T82942

Ep300/CREBBP-IN-2

Cat.No: T73921

Ep300/CREBBP-IN-3

Cat.No: T73922

Ep300/CREBBP-IN-8

Cat.No: T73920

Ep300/CREBBP-IN-4

Cat.No: T73923

Cat.No: T15108

Target: Prostaglandin Receptor

Cat.No: T14148

Target: Prostaglandin Receptor

EP4 receptor antagonist 1

Cat.No: T11211

Target: Prostaglandin Receptor

Cat.No: T14975

Synonym: CJ-042794

Target: Others

Treprostinil diethanolamine

Cat.No: T63349

Synonym: UT-15C

Target: Prostaglandin Receptor

Cat.No: T3306

Synonym: PF 04418948,PF04418948

Target: Prostaglandin Receptor

Cat.No: T5482

Target: Prostaglandin Receptor

Cat.No: T70042

Cat.No: T28252

Cat.No: T15689

Synonym: CM9,GW671021

Target: Prostaglandin Receptor

Cat.No: T23404

Target: Others

Cat.No: T15642

Target: Prostaglandin Receptor

17-phenyl trinor Prostaglandin E2 ethyl amide

Cat.No: T37996

Synonym: 17-phenyl trinor Prostaglandin E2 ethyl amide

19(R)-hydroxy Prostaglandin E1

Cat.No: T37778

Synonym: 19(R)-hydroxy Prostaglandin E1

SC 51089 free base

Cat.No: T72513

Cat.No: T26925

Synonym: Butaprostum,TR-4979,(R)-Butaprost

Alprostadil sodium

Cat.No: T29907

Synonym: PGE1 sodium salt,Prostaglandin E1 sodium

Cat.No: T36080

Synonym: ONO-4819

Cat.No: T5150

Synonym: LRX-15,曲前列环素,Orenitram,曲前列尼尔,Remodulin

Target: Prostaglandin Receptor

Cat.No: T23331

Synonym: SC 51089 free base

Target: Prostaglandin Receptor

Anisotropine Methylbromide

Cat.No: T4981

Target: Prostaglandin Receptor, AChR

Cat.No: TQ0290

Synonym: AE 3-208

Target: Prostaglandin Receptor

Cat.No: T37441

Cat.No: T40738

Synonym: CAY10580

Tafluprost acid

Cat.No: T20142

Synonym: UNII-WTV8EPZ396

Cat.No: T15828

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1626	Prostaglandin E1 前列地尔,PGE1,列腺素E1,Alprostadil	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。

天然产物

Prostaglandin E1

Cat.No: T1626

Synonym: 前列地尔,PGE1,列腺素E1,Alprostadil

Target: Endogenous Metabolite, Prostaglandin Receptor

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