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28

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3458	EED226	Histone Methyltransferase	Chromatin/Epigenetic
	EED226 是多梳抑制复合物 2 抑制剂，是一种有效的、选择性的、可口服的胚胎外胚层发育 (EED) 抑制剂，IC50 为 22 nM，具有强抗肿瘤活性。当 H3K27me0 肽用作体外酶法测定的底物时，它抑制 PRC2的 IC50为 23.4 nM。
T12554	PROTAC EED degrader-2	Others	Others
	PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.
T12553	PROTAC EED degrader-1	Others	Others
	PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.
T61825	EED ligand 1
	EED ligand 1 is a highly versatile, potent, and effective inhibitor that specifically targets the EED subunit of the polycomb repressive complex 2 (PRC2) methyltransferase.
T17649	Boc-GABA-OH	Others; PROTAC Linker	Others; PROTAC
	Boc-GABA-OH 是一种 PROTAC linker，可用于 UNC6852 的合成。其中 UNC6852 是靶向 EED 的 PROTAC 降解剂。
T13954	UNC6852	Histone Methyltransferase; Ligands for Target Protein for PROTAC	Chromatin/Epigenetic; PROTAC
	UNC6852 包含一个 EED 配体 (IC50 = 247 nM) 和一个 von Hippel-Lindau 配体，是一种基于 PROTAC 的特异性多梳抑制复合物 2 (PRC2) 降解剂。
T9681	MAK-683 hydrochloride	Histone Methyltransferase	Chromatin/Epigenetic
	MAK683 hydrochloride 是胚胎外胚层发育 (EED) 抑制剂。MAK683 hydrochloride 在 EED Alphascreen， ELISA 和 LC-MS 试验中测得的IC50 值分别为 59，26，89 nM。
T17931	EED226-COOH	Others	Others
	EED226-COOH, derived from EED226, serves as a ligand targeting the EED protein for PROTAC applications. It attaches to a VHL ligand through a linker, culminating in the formation of UNC6852, which specifically degrades PRC2[1].
T22322	EEDi-5285 UM-EEDi-5285,EEDI5285	Histone Methyltransferase	Chromatin/Epigenetic
	EEDi-5285 是一种非常有效且具有口服活性的胚胎外胚层发育 (EED) 抑制剂，结合 EED 蛋白的 IC50 值为 0.2 nM，并具有抗癌活性。
T40223	EEDi-5273
	EEDi-5273 is a highly potent and orally efficacious inhibitor of EED, with an approximate IC50 value of 0.2 nM. This compound exhibits exceptional activity, capable of achieving complete and persistent regression of tumors.
T124238	Rheediaxanthone A
	Rheediaxanthone A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124238。
T71923	EEDQ
	EEDQ is an irreversible dopamine-receptor antagonist.EEDQ is also a highly specific reagent for carboxyl groups. It enables the coupling of acylamino acids with amino acid esters in high yield and without racemization.
T76665	Z-LEED-FMK
	Z-LEED-FMK 是 caspase-13和 caspase-4抑制剂。Z-LEED-FMK 还能抑制S. typhimurium 感染的巨噬细胞中caspase-1的加工。
T15201	MAK683	Histone Methyltransferase	Chromatin/Epigenetic
	MAK683 是胚胎外胚层发育 (EED) 抑制剂。在 EED Alphascreen 结合、LC-MS 和 ELISA 测定中，IC50值为 59、89 和 26 nM。
T10205	A-395	Histone Methyltransferase	Chromatin/Epigenetic
	A-395 是一种多梳抑制复合物 2 (PRC2) 蛋白质-蛋白质相互作用的拮抗剂，可有效抑制三聚体 PRC2 复合物 (EZH2-EED-SUZ12)，IC50为 18 nM。
T13765	MAK683-CH2CH2COOH	Others	Others
	MAK683-CH2CH2COOH 与 EED (胚胎外胚层发育蛋白) 结合。基于MAK683-CH2CH2COOH 和 E3 泛素连接酶的 VHL 配体，设计了靶向EED 的PROTACs， PROTAC EED degrader-1 和 PROTAC EED degrader-2 。
T73945	MAK683-CH2CH2COOH hydrochloride
	MAK683-CH2CH2COOH 与 EED (胚胎外胚层发育蛋白) 结合。MAK683-CH2CH2COOH 和 E3 泛素连接酶的 VHL 配体设计了 PROTACEED degrader-1 和 PROTACEED degrader-2 。
T18673	(S,R,S)-AHPC-O-Ph-PEG1-NH2 VH032-O-Ph-PEG1-NH2	Others	Others
	(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) serves as an E3 ligase ligand-linker conjugate, integrating a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is utilized in PROTAC EED degrader-1, a PROTAC that targets EED with a potency (pKD) of 9.02[1].
T18664	(S,R,S)-AHPC-C3-NH2 VH032-C3-NH2	Others	Others
	(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized conjugate consisting of an E3 ligase ligand-linker and the VH032 based VHL ligand, which is commonly used in PROTAC technology. This compound serves as a key component in the synthesis of various PROTACs, including UNC6852. UNC6852 is a bivalent chemical degrader specifically targeting EED [1].
T17660	Boc-NH-PEG1-Ph-O-CH2COOH	Others	Others
	Boc-NH-PEG1-Ph-O-CH2COOH is a PROTAC Linker which is used for the EED-targeted PROTAC[1].
T18672	(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc VH032-O-Ph-PEG1-NH-Boc	Others	Others
	(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc (VH032-O-Ph-PEG1-NH-Boc) is an E3 ligase ligand-linker conjugate, specifically designed for targeting the EED protein in PROTAC applications[1].
T40154	FTX-6058
	FTX-6058 is a potent orally active inhibitor targeting Embryonic Ectoderm Development (EED). It effectively induces HbF protein expression in both cell and murine models. This compound holds significant potential for researching select hemoglobinopathies such as sickle cell disease and β-thalassemia.
T18665	(S,R,S)-AHPC-C4-NH2 dihydrochloride VH032-C4-NH2 dihydrochloride	Others	Others
	(S,R,S)-AHPC-C4-NH2 dihydrochloride is a chemically derived E3 ligase ligand-linker conjugate, consisting of the (S,R,S)-AHPC VHL ligand and a linker specifically designed for EED-Targeted PROTAC[1].
T17653	Boc-NH-C4-acid Boc-5-氨基戊酸	Others; PROTAC Linker	Others; PROTAC
	Boc-NH-C4-acid 是一种属于 Alkyl/ether 类的 PROTAC linker，可用于 PROTAC1 的合成，并且可以降解 PRC2 中的 EED，EZH2，和 SUZ12。
T61975	Pociredir
	Pociredir (FTX-6058) 是一种有效的、选择性的、具有口服活性的胚胎外胚层发育蛋白 (EED) 小分子抑制剂（KD= 0.163 nM）。Pociredir (FTX-6058) 在研究炎症或血红蛋白病中具有研究价值，如镰状细胞病 (SCD)。
T18666	(S,R,S)-AHPC-C4-NH2 VH032-C4-NH2	Others	Others
	(S,R,S)-AHPC-C4-NH2 is a custom-synthesized conjugate of an E3 ligase ligand-linker, which combines the VHL ligand based on (S,R,S)-AHPC and a linker specifically designed for EED-Targeted PROTAC[1].
T40155	FTX-6058 hydrochloride
	FTX-6058 hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED), with the ability to induce HbF protein expression in both cell and murine models. This compound is particularly valuable in the research of select hemoglobinopathies, such as sickle cell disease and β-thalassemia.
T18663	(S,R,S)-AHPC-C3-NH2 TFA (2361119-88-0 free base) (S,R,S)-AHPC-C3-NH2 TFA,VH032-C3-NH2 TFA	Others	Others
	(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, suc

化合物

Cat.No: T3458

Target: Histone Methyltransferase

PROTAC EED degrader-2

Cat.No: T12554

Target: Others

PROTAC EED degrader-1

Cat.No: T12553

Target: Others

Cat.No: T61825

Cat.No: T17649

Target: Others, PROTAC Linker

Cat.No: T13954

Target: Histone Methyltransferase, Ligands for Target Protein for PROTAC

MAK-683 hydrochloride

Cat.No: T9681

Target: Histone Methyltransferase

Cat.No: T17931

Target: Others

Cat.No: T22322

Synonym: UM-EEDi-5285,EEDI5285

Target: Histone Methyltransferase

Cat.No: T40223

Rheediaxanthone A

Cat.No: T124238

Cat.No: T71923

Cat.No: T76665

Cat.No: T15201

Target: Histone Methyltransferase

Cat.No: T10205

Target: Histone Methyltransferase

MAK683-CH2CH2COOH

Cat.No: T13765

Target: Others

MAK683-CH2CH2COOH hydrochloride

Cat.No: T73945

(S,R,S)-AHPC-O-Ph-PEG1-NH2

Cat.No: T18673

Synonym: VH032-O-Ph-PEG1-NH2

Target: Others

(S,R,S)-AHPC-C3-NH2

Cat.No: T18664

Synonym: VH032-C3-NH2

Target: Others

Boc-NH-PEG1-Ph-O-CH2COOH

Cat.No: T17660

Target: Others

(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc

Cat.No: T18672

Synonym: VH032-O-Ph-PEG1-NH-Boc

Target: Others

Cat.No: T40154

(S,R,S)-AHPC-C4-NH2 dihydrochloride

Cat.No: T18665

Synonym: VH032-C4-NH2 dihydrochloride

Target: Others

Cat.No: T17653

Synonym: Boc-5-氨基戊酸

Target: Others, PROTAC Linker

Cat.No: T61975

(S,R,S)-AHPC-C4-NH2

Cat.No: T18666

Synonym: VH032-C4-NH2

Target: Others

FTX-6058 hydrochloride

Cat.No: T40155

(S,R,S)-AHPC-C3-NH2 TFA (2361119-88-0 free base)

Cat.No: T18663

Synonym: (S,R,S)-AHPC-C3-NH2 TFA,VH032-C3-NH2 TFA

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T13626	Cottonseed oil	Others	Others
	Cottonseed oil 是一种提取自棉花种子中的食用油，是一种植物油中杀虫能力极强的油。
T6520	Grape Seed Extract Grape Seed P.E.,葡萄籽提取物	Apoptosis; Others	Apoptosis; Others
	Grape Seed Extract (Grape Seed P.E.) 是葡萄植物 Vitis vinifera 的种子分泌物，能诱导人类结肠直肠癌细胞凋亡，具有抗炎和抗增殖作用。它对脂肪代谢酶、胰脂肪酶和脂蛋白脂肪酶有抑制作用。

天然产物

Cat.No: T13626

Target: Others

Grape Seed Extract

Cat.No: T6520

Synonym: Grape Seed P.E.,葡萄籽提取物

Target: Apoptosis, Others

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