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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T27200	DOX−NOP1 HCl doxorubicin-NOP1 conjugate,doxorubicin-NOP1 HCl,DOX−NOP1 Hydrochloride
	DOX−NOP1 is a molecular hybrid covalently joining doxorubicin (DOX) and NOP1. DOX−NOP1 showed similar increased toxicity toward resistant cancer cells and, in addition, lower cardiotoxicity than DOX.
TQ0049	MC-DOXHZN hydrochloride MC-DOXHZN盐酸盐,Doxorubicin(6-maleimidocaproyl)hydrazone hydrochloride	Topoisomerase	DNA Damage/DNA Repair
	MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
T11090L1	Aldoxorubicin hydrochloride Aldoxorubicin hydrochloride (1361644-26-9 Free base）	Topoisomerase	DNA Damage/DNA Repair
	Aldoxorubicin hydrochloride 是 Doxorubicin (DNA 拓扑异构酶 II 抑制剂) 的白蛋白结合前药。Aldoxorubicin hydrochloride 在酸性条件下从白蛋白中释放出来。 Aldoxorubicin hydrochloride 显示出有效的抗肿瘤活性。
T4247	I-CBP112 hydrochloride	Epigenetic Reader Domain	Chromatin/Epigenetic
	I-CBP112 hydrochloride 是含溴结构域转录因子的选择性抑制剂，靶向 CBP/p300 溴结构域。在体内外，它以剂量依赖性方式显着降低 MLL-AF9(+) 急性髓细胞白血病细胞的白血病起始潜力，还增加 BET 溴结构域抑制剂 JQ1 以及阿霉素的细胞毒活性。
T40736	Doxorubicinol hydrochloride 13-Dihydroadriamycin hydrochloride
	Doxorubicinol hydrochloride, also known as 13-Dihydroadriamycin hydrochloride, is a secondary alcohol metabolite derived from Doxorubicin.
T71713	Pirarubicin HCl
	Pirarubicin HCl is the hydrochloride salt form of pirarubicin, an analogue of the anthracycline antineoplastic antibiotic doxorubicin with antineoplastic activity. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.

化合物

DOX−NOP1 HCl

Cat.No: T27200

Synonym: doxorubicin-NOP1 conjugate,doxorubicin-NOP1 HCl,DOX−NOP1 Hydrochloride

Target:

MC-DOXHZN hydrochloride

Cat.No: TQ0049

Synonym: MC-DOXHZN盐酸盐,Doxorubicin(6-maleimidocaproyl)hydrazone hydrochloride

Target: Topoisomerase

Aldoxorubicin hydrochloride

Cat.No: T11090L1

Synonym: Aldoxorubicin hydrochloride (1361644-26-9 Free base）

Target: Topoisomerase

I-CBP112 hydrochloride

Cat.No: T4247

Synonym:

Target: Epigenetic Reader Domain

Doxorubicinol hydrochloride

Cat.No: T40736

Synonym: 13-Dihydroadriamycin hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
T1020	Doxorubicin hydrochloride Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127	Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素，是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化，还可诱导凋亡和自噬。