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36

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36688	Deoxyguanosine triphosphate trisodium salt Deoxyguanosine 5-triphosphate,2'-Deoxyguanosine-5'-triphosphate trisodium salt,dGTP trisodium salt	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Deoxyguanosine triphosphate trisodium salt (2'-Deoxyguanosine-5'-triphosphate trisodium salt) 是细胞中用于 DNA 合成的核苷酸前体，可用于逆转录聚合酶链反应 (RT-PCR) 中以进行 DNA 扩增。
T7782	3'-Deoxyguanosine	Others	Others
	3'-Deoxyguanosine 是一种配体，可与酶如嘌呤核苷磷酸化酶和受体复合。
T37636	2'-Deoxyguanosine 5'-monophosphate disodium 5′-dGMP disodium	Endogenous Metabolite	Metabolism
	2'-Deoxyguanosine 5'-monophosphate disodium (5'-dGMP disodium) 是一种核酸三磷酸鸟苷（GTP）衍生物，可作为可氧化靶标，可用于和其他化合物组成多元配合物。
T6746	6-Thio-2'-Deoxyguanosine 6-Thio-dG,β-TGdR	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	6-Thio-2'-Deoxyguanosine (β-TGdR) 是一种核苷类似物和端粒酶底物，可以通过端粒酶掺入重新合成的端粒中。
T39171	7-Iodo-7-deaza-2'-deoxyguanosine 7-Deaza-7-Iodo-2'-deoxyguanosine,7-Iodo-7-deaza-2'-deoxyguanosine
	7-Iodo-7-deaza-2'-deoxyguanosine (7-Deaza-7-Iodo-2'-dG) is a deoxyguanosine derivative suitable for applications in DNA synthesis and sequencing reactions.
T40192	dGTP 2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	dGTP（2'-Deoxyguanosine-5'-triphosphate）作为脱氧核糖核酸（DNA）合成的基本单元，属于鸟苷核苷酸，对8-O-GDP、8-O-dGTP、8-O-GTP及8-O-dGTP的氧化损伤具有高度敏感性。
T0688	Ganciclovir BW 759,更昔洛韦,RS-21592,2'-Nor-2'-deoxyguanosine	Nucleoside Antimetabolite/Analog; Others; Antibiotic; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir (2'-Nor-2'-deoxyguanosine) 是核苷类似物和口服抗病毒药物，对CMV 具有抗病毒活性。它用于治疗与艾滋病相关的巨细胞病毒感染的并发症。
T35652	2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
	2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum. In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.
T22337	Ganciclovir sodium RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠	Nucleoside Antimetabolite/Analog; Others; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir sodium (Cytovene IV sodium) 是核苷类似物和口服抗病毒药物，具有抗病毒活性，尤其是针对巨细胞病毒和单纯疱疹病毒 1 型。
TNU1523	8-Methyl-2’-deoxyguanosine
	8-Methyl-2'-deoxyguanosine is a Nucleoside Derivative - 8-Modified purine nucleoside.
TNU0197	3’-Azido-3’-deoxyguanosine
	Nucleoside Derivatives - Azido-nucleosides, 3’-Modified nucleosides
TNU1611	8-Aza-2’-deoxyguanosine
	Nucleoside Derivatives –8-Modified purine nucleosides
TNU1029	N2-(2-Furanylmethyl)-2’-deoxyguanosine
	Nucleoside Derivatives –2’-Deoxy nucleoside; 2-Modified nucleoside; Drugs and Inhibitors; DNA adduct MF-dG
TNU0931	8-Benzyloxy-2’-deoxyguanosine
	8-Benzyloxy-2'-deoxyguanosine is a Nucleoside Derivative - 8-Modified purine nucleoside.
T66137	N2-Isobutyryl-2-deoxyguanosine
	N2-Isobutyryl-2-deoxyguanosine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66137，CAS号为 68892-42-2。
TNU0792	8-Bromo-2’-deoxyguanosine
	8-Bromo-2'-deoxyguanosine is a 2'-Deoxynucleoside; Halo-nucleoside.
TNU0447	8-Hydroxy-3’-deoxyguanosine
	Nucleoside Derivatives - 3’-Deoxy-nucleosides; 8-Modified purine nucleosides
TNU0446	8-Benzyloxy-3’-deoxyguanosine
	Nucleoside Derivatives - 3’-Modified nucleosides, 8-Modified purine nucleosides
TNU0445	8-Bromo-3’-deoxyguanosine
	Nucleoside Derivatives - 3’-Modified nucleosides; 8-Modified nucleosides; Halo-nucleosides；3’-Deoxy nucleosides
TNU1612	8-Aza-alpha-D-2’-deoxyguanosine
	Nucleoside Derivatives –8-Modified purine nucleosides; Alpha-nucleosides
T83248	7-Deaza-2′-deoxyguanosine 5′-triphosphate 7-Deaza-2'-dGTP	Telomerase	DNA Damage/DNA Repair
	7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP)为核苷酸类似物，兼具端粒酶抑制活性(IC50为11μM)。
T40800	5'-O-DMT-N2-ibu-dG 5'-O-DMT-N2-ibu-dG,N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine
	5'-O-DMT-N2-ibu-dG, also known as N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine, is a deoxynucleoside commonly employed in synthesizing oligonucleotides.
T83810	3'-Amino-3'-deoxyguanosine-5'-O-triphosphate sodium 3'-amino-dGTP
	3'-氨基-3'-去氧鸟苷-5'-O-三磷酸（3'-氨基-dGTP）是一种经过胺修饰的核苷酸。它能终止由大肠杆菌中的RNA聚合酶催化的RNA链合成。3'-氨基-dGTP已用于合成报警素鸟苷五磷酸（pppGpp）的一种不可水解衍生物。
T83831	Sp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) sodium Sp-dGTP-α-S
	Sp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) 是一种含硫异构体，属于核苷酸三磷酸2'-脱氧鸟苷-5'-O-三磷酸(dGTP)。它通过抑制脱氧核苷酸三磷酸三磷酸水解酶SAMHD1 (Ki = 820 nM)发挥作用。
TNU1027	7-Deaza-2’-deoxyguanosine; 2-Amino-7-(2-deoxy-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one
	Nucleoside Derivatives - 7-Deaza-purine nucleoside
T60371	7-Deaza-2',3'-dideoxyguanosine
	7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) 是一种 2',3'-dideoxynucleoside 5'-triphosphate，抑制HIV-1逆转录酶，Ki 值为 25 nM。
T1533	Valganciclovir hydrochloride Valganciclovir HCl,Valcyt,缬更昔洛韦盐酸盐,Valcyte	Others; Antiviral	Immunology/Inflammation; Others
	Valganciclovir hydrochloride (Valganciclovir HCl) 是 ganciclovir 的原药，具有抗巨细胞病毒活性，可抑制病毒 DNA 聚合酶和病毒复制。
T1643	Penciclovir 喷昔洛韦,BRL 39123,VSA 671	HCV Protease; Antifection; HSV	Microbiology/Virology; Proteases/Proteasome
	Penciclovir (BRL 39123) 是一种疱疹病毒核苷类似物 DNA 聚合酶抑制剂。它作用于HSV1 和 2，IC50分别为 0.04-1.8 μg/mL 和 0.06-4.4 μg/mL。
T36944	Ara-G	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物，可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP)，从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。
T40773	7-Deaza-7-propargylamino-3'-azidomethyl-dGTP
	7-Deaza-7-propargylamino-3'-azidomethyl-dGTP is a commonly employed deoxyguanosine triphosphate (dGTP) analog in next generation sequencing (NGS).
T29377	3-(2'-Deoxyribofuranosyl)pyrimido(1,2-a)purin-10(3H)-one
	3-(2'-Deoxyribofuranosyl)pyrimido(1,2-a)purin-10(3H)-one is a malondialdehyde-deoxyguanosine adduct.
T36100	K-TMZ
	K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.
T70859	ent-Abacavir
	ent-Abacavir is an enatiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuroni...
T70092	ent-Entecavir
	ent-Entecavir is an enantiomeric impurity of the antiviral drug Entecavir. Entecavir is an oral antiviral drug used in the treatment of hepatitis B virus (HBV) infection. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. More specifically, it is a deoxyguanosine analogue belonging to a class of carbocyclic nucleosides, that inhibits reverse transcription, DNA replication and transcription in the viral r...
T28398	Phenanthriplatin cis-[Pt(NH3)2-(phenanthridine)Cl]NO3
	Phenanthriplatin, also known as cis-[Pt(NH3)2-(phenanthridine)Cl]NO3, is a new drug candidate. It belongs to a family of platinum(II)-based agents which includes cisplatin, oxaliplatin and carboplatin. Phenanthriplatin Acts As a Covalent Poison of Topoiso
T35646	4-oxo-2-Nonenal 4-oxo-2-Nonenal,4-ONE
	4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid. [1] [2] It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.[1][2][3] 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.[4][5][6] It actively modifies histidine and lysine residues on prot...

化合物

Deoxyguanosine triphosphate trisodium salt

Cat.No: T36688

Synonym: Deoxyguanosine 5-triphosphate,2'-Deoxyguanosine-5'-triphosphate trisodium salt,dGTP trisodium salt

Target: Nucleoside Antimetabolite/Analog

3'-Deoxyguanosine

Cat.No: T7782

Target: Others

2'-Deoxyguanosine 5'-monophosphate disodium

Cat.No: T37636

Synonym: 5′-dGMP disodium

Target: Endogenous Metabolite

6-Thio-2'-Deoxyguanosine

Cat.No: T6746

Synonym: 6-Thio-dG,β-TGdR

Target: Others, DNA/RNA Synthesis

7-Iodo-7-deaza-2'-deoxyguanosine

Cat.No: T39171

Synonym: 7-Deaza-7-Iodo-2'-deoxyguanosine,7-Iodo-7-deaza-2'-deoxyguanosine

Cat.No: T40192

Synonym: 2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T0688

Synonym: BW 759,更昔洛韦,RS-21592,2'-Nor-2'-deoxyguanosine

Target: Nucleoside Antimetabolite/Analog, Others, Antibiotic, Antifection, HSV

2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)

Cat.No: T35652

Ganciclovir sodium

Cat.No: T22337

Synonym: RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠

Target: Nucleoside Antimetabolite/Analog, Others, Antifection, HSV

8-Methyl-2’-deoxyguanosine

Cat.No: TNU1523

3’-Azido-3’-deoxyguanosine

Cat.No: TNU0197

8-Aza-2’-deoxyguanosine

Cat.No: TNU1611

N2-(2-Furanylmethyl)-2’-deoxyguanosine

Cat.No: TNU1029

8-Benzyloxy-2’-deoxyguanosine

Cat.No: TNU0931

N2-Isobutyryl-2-deoxyguanosine

Cat.No: T66137

8-Bromo-2’-deoxyguanosine

Cat.No: TNU0792

8-Hydroxy-3’-deoxyguanosine

Cat.No: TNU0447

8-Benzyloxy-3’-deoxyguanosine

Cat.No: TNU0446

8-Bromo-3’-deoxyguanosine

Cat.No: TNU0445

8-Aza-alpha-D-2’-deoxyguanosine

Cat.No: TNU1612

7-Deaza-2′-deoxyguanosine 5′-triphosphate

Cat.No: T83248

Synonym: 7-Deaza-2'-dGTP

Target: Telomerase

5'-O-DMT-N2-ibu-dG

Cat.No: T40800

Synonym: 5'-O-DMT-N2-ibu-dG,N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine

3'-Amino-3'-deoxyguanosine-5'-O-triphosphate sodium

Cat.No: T83810

Synonym: 3'-amino-dGTP

Sp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83831

Synonym: Sp-dGTP-α-S

7-Deaza-2’-deoxyguanosine; 2-Amino-7-(2-deoxy-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one

Cat.No: TNU1027

7-Deaza-2',3'-dideoxyguanosine

Cat.No: T60371

Valganciclovir hydrochloride

Cat.No: T1533

Synonym: Valganciclovir HCl,Valcyt,缬更昔洛韦盐酸盐,Valcyte

Target: Others, Antiviral

Cat.No: T1643

Synonym: 喷昔洛韦,BRL 39123,VSA 671

Target: HCV Protease, Antifection, HSV

Cat.No: T36944

Target: Nucleoside Antimetabolite/Analog

7-Deaza-7-propargylamino-3'-azidomethyl-dGTP

Cat.No: T40773

3-(2'-Deoxyribofuranosyl)pyrimido(1,2-a)purin-10(3H)-one

Cat.No: T29377

Cat.No: T36100

Cat.No: T70859

Cat.No: T70092

Phenanthriplatin

Cat.No: T28398

Synonym: cis-[Pt(NH3)2-(phenanthridine)Cl]NO3

4-oxo-2-Nonenal

Cat.No: T35646

Synonym: 4-oxo-2-Nonenal,4-ONE

Cat. No.	Product Name	Target	Signaling Pathways
T22218	2'-Deoxyguanosine Deoxyguanosine,Guanine deoxyriboside	Endogenous Metabolite	Metabolism
	2'-Deoxyguanosine (Guanine deoxyriboside) 是一种嘌呤核苷，可被2'-dG-II家族的成员识别。2'-Deoxyguanosine 与衰老、突变和致癌有关，可被分子氧氧化。
T8343	8-Hydroxy-2'-deoxyguanosine 8-OHdG,8-Hydroxydeoxyguanosine,8-Hydroxy-2-Deoxyguanosine,2'-Deoxy-8-oxoguanosine,8 OHdG,8-Oxo-dG,8-OH-脱氧鸟嘌呤,8 Oxo dG,8-Oxo-2'-deoxyguanosine	Endogenous Metabolite	Metabolism
	8-Hydroxy-2'-deoxyguanosine (8-OHdG) 是致癌反应和氧化应激的关键生物标志物。
T4715	2'-Deoxyguanosine monohydrate 2'-脱氧鸟苷一水合物,Guanine-2'-deoxyriboside	Others; Endogenous Metabolite	Metabolism; Others
	2'-Deoxyguanosine monohydrate (Guanine-2'-deoxyriboside) 是内源性代谢产物的一种。

天然产物

2'-Deoxyguanosine

Cat.No: T22218

Synonym: Deoxyguanosine,Guanine deoxyriboside

Target: Endogenous Metabolite

8-Hydroxy-2'-deoxyguanosine

Cat.No: T8343

Synonym: 8-OHdG,8-Hydroxydeoxyguanosine,8-Hydroxy-2-Deoxyguanosine,2'-Deoxy-8-oxoguanosine,8 OHdG,8-Oxo-dG,8-OH-脱氧鸟嘌呤,8 Oxo dG,8-Oxo-2'-deoxyguanosine

Target: Endogenous Metabolite

2'-Deoxyguanosine monohydrate

Cat.No: T4715

Synonym: 2'-脱氧鸟苷一水合物,Guanine-2'-deoxyriboside

Target: Others, Endogenous Metabolite

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