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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T37725	Tetrahydrodeoxycorticosterone 21-Hydroxypregnanolone,Tetrahydro-11-deoxycorticosterone	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) 是一种有效的 GABAA 受体正变构调节剂 (PAM)，具有神经保护活性，选择性抑制神经类固醇介导的 GABA 诱发电流在 GABAA 受体上的增强，可用于研究神经疾病。
T11394	GFB-8438	TRP/TRPV Channel	Membrane transporter/Ion channel
	GFB-8438 是有效的TRPC5选择性抑制剂，对 hTRPC5 和 hTRPC4 的IC50分别为 0.18 和 0.29 μM。它对 TRPC6、其他 TRP 家族成员、NaV1.5 具有良好的选择性，对 hERG 通道的活性也有限。它对小鼠足细胞的保护作用。
T26841	BMS 182874 BMS182874,BMS-182874	Endothelin Receptor	GPCR/G Protein
	BMS 182874 是一种口服有效的高选择性内皮素受体 endothelin receptor ETA 拮抗剂，对 ETA 的 IC50 值为0.150 μM，对 ETA 的 Ki 值为0.055 μM。BMS 182874 能够在大鼠高血压模型中降低 Deoxycorticosterone acetate 诱导的动脉压，可用于研究心血管疾病。
TC0008	Desoxycorticosterone pivalate DOCP	Others	Others
	Deoxycorticosterone (DOCP) is a mineralocorticoid and is an analog of deoxycorticosterone. Deoxycorticosterone pivalate is used in the treatment of canine low adrenal cortex hormones.
T33370	Metyrapol SU 5236,SU-5236,SU5236
	Metyrapol is a competitive inhibitor of 11-deoxycorticosterone hydroxylation by 11β-hydroxylase.
T35876	Chlorthalidone Impurity G
	Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) an...

化合物

Tetrahydrodeoxycorticosterone

Cat.No: T37725

Synonym: 21-Hydroxypregnanolone,Tetrahydro-11-deoxycorticosterone

Target: GABA Receptor

GFB-8438

Cat.No: T11394

Synonym:

Target: TRP/TRPV Channel

BMS 182874

Cat.No: T26841

Synonym: BMS182874,BMS-182874

Target: Endothelin Receptor

Desoxycorticosterone pivalate

Synonym: SU 5236,SU-5236,SU5236

Target:

Chlorthalidone Impurity G

Cat.No: T35876

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T20302	Deoxycorticosterone Desoxycorticosterone,去氧皮质酮,Desoxycorticosteronum,Desoxycortone	Endogenous Metabolite	Metabolism
	Deoxycorticosterone (Desoxycortone) 是由肾上腺产生的类固醇代谢物。 Deoxycorticosterone 是醛固酮前体，具有盐皮质激素活性。
T3033	Deoxycorticosterone acetate 醋酸去氧皮质酮,DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate,醋酸脱氧皮质酮	Glucocorticoid Receptor; Endogenous Metabolite; Adrenergic Receptor	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience
	Deoxycorticosterone acetate (Cortexone acetate) 是肾上腺产生的类固醇激素，具有盐皮质激素活性，并作为醛固酮的前体。