首页工具

登录

搜索结果

Search Results for " dna polymerase-in-1 "

22

抑制剂 & 化合物

4

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T80644	DNA polymerase-IN-1	Antiviral; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation
	DNA polymerase-IN-1 作为DNA聚合酶抑制剂，展现出对肿瘤细胞的抗增殖活性，其半抑制浓度（IC50）为20.7 μM。DNA polymerase-IN-1 抑制 Taq DNA 聚合酶，IC 值低于 250μM。DNA polymerase-IN-1 通过RT-PCR检测在体外显示出抗逆转录病毒活性，可用于研究氧化损伤和结直肠癌。
T28918	Talviraline Bay 10-8979,HBY 097,Bay10-8979,Bay-108979,Bay108979,Bay 108979,Bay-10-8979	HIV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Talviraline (Bay 10-8979) 是一种 RNA 引导的 DNA 聚合酶抑制剂。Talviraline 对多种人类细胞系以及新鲜人类外周血淋巴细胞和巨噬细胞中的 HIV-1 诱导的细胞杀伤和 HIV-1 复制具有很强的抑制作用。
T60187	RP-6685	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Polθ), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Polθ. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model [1].
T14313	Apricitabine AVX754,SPD754	HIV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Apricitabine (SPD754) 是一种具有高选择性和口服活性的HIV-1逆转录酶抑制剂(Ki=0.08μM)，是2′-脱氧-3′-氧-4′-硫代胞苷(dOTC)的(-)对映体。 Apricitabine 对DNA 聚合酶α、β和γ具有抑制作用，Ki 值分别为300μM、12μM 和112.25μM。Apricitabine 在抗逆转录病毒HIV 感染者中显示出良好的抗逆转录病毒治疗效果，具有良好的耐受性和较低的选择性抗性。
T3157	COH29 RNR Inhibitor COH29	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	COH29 (RNR Inhibitor COH29) 是一种口服可用的芳香族取代噻唑，是人类核糖核苷酸还原酶 (RNR) 的抑制剂，具有潜在的抗肿瘤活性。它抑制核糖核苷酸还原酶的IC50为 16 μM。
T79308	DNA polymerase-IN-3	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA polymerase-IN-3 (Compd 5b) 为香豆素衍生物，对 Taq DNA聚合酶具有抑制活性，适用于增值性疾病研究。
T79307	DNA polymerase-IN-2	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA polymerase-IN-2 (Compd 3c)为香豆素衍生物，对Taq DNA聚合酶具有抑制作用，IC50为48.25 μM，适用于增殖性疾病研究。
T79922	Taq DNA polymerase	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Taq DNA 聚合酶是一种在PCR过程中广泛使用的耐热性酶，由Thermus aquaticus细菌产生，其功能是在高温下合成DNA链。
T82536	DNA polymerase-IN-4
	DNA polymerase-IN-4 (Compd 5c)，香豆素衍生物，显示出抗逆转录病毒活性，IC50为134.22 μM。
T74108	ddTTP
	ddTTP 是一类双脱氧核糖核苷酸 (ddNTPs)，可作为 DNA 聚合酶链延长抑制剂用于 DNA 测序。
T78637	ddTTP trisodium	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	ddTTP trisodium是一种ddNTPs，用于抑制DNA聚合酶链延长，应用于DNA测序。
T28585	Ro 31-8588 Ro-31-8588
	Talviraline is a RNA-directed DNA polymerase inhibitor. HBY 097 is a highly potent inhibitor of HIV-1 replication and HIV-1 induced cell killing in a variety of human cell lines as well as in fresh human peripheral blood lymphocytes and macrophages.
T81249	Ru3	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Ru3是一种poly(ADP-ribose)polymerase 1抑制剂，能够通过诱导DNA损伤、抑制DNA修复机制、扰乱细胞周期、降低线粒体膜电位及增加reactive oxygen species水平来诱导MCF-7细胞的apoptosis。
T79923	T7 RNA polymerase	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	T7 RNA polymerase是一种由大肠杆菌表达的聚合酶，由T7噬菌体的RNA聚合酶基因编码。它在合成mRNA体外转录（IVT）过程中显示出高度专一性。T7 RNA polymerase能在Mg2+的作用下，针对含有T7启动子序列的单链或双链DNA模板，使用NTP作为底物进行RNA合成，产生的RNA与DNA模板的启动子下游区域互补。
T28494	R-82913 NSC 637653, 9-Cl-Tibo,R 82913,R82913. 9-Cmbib
	R-82913 is a RNA-directed DNA polymerase inhibitor. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 of 0.15 microM. R82913 was 20-fold
T61492	Idoxuridine hydrate
	Idoxuridine hydrate (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is a competitive inhibitor of phosphorylases. As an iodinated thymidine analogue, it effectively inhibits DNA polymerase and hinders viral replication, making it useful in the treatment of viral eye infections such as herpes simplex keratitis. Against feline herpesvirus, Idoxuridine has been found to have an IC50 value of 4.3 μM [1].
T37106	2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)
	2'-Deoxyadenosine-5'-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5'-triphosphate .1dATP is a substrate for DNA polymerase in the synthesis of DNA.2It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.1dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.3,4dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations ...
T36745	cDPCP
	cDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting proliferation of MDCK cells expressing the human transporters with IC50values of 8.1 and 1.5 μM, respectively. cDPCP inhibits RNA polymerase II-mediated transcription in a reporter assay using HeLa cells. It increases survival in murine S180 sarcoma and P388 leukemia models when ad...
T36490	AZT triphosphate TEA
	AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in ...
T72017	6(5H)-Phenanthridinone
	6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes. In vivo, 6(5H)-phenanthridinone reduces spinal cord expression of inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of experimenta...
T83854	BRC4wt TFA
	BRC4wt是一种从人类BRCA2的BRC4重复区(1521-1536)衍生而来的乙酰化肽，并且是BRCA2与RAD51之间的蛋白质-蛋白质相互作用的抑制剂。当与阳离子穿膜肽(Arg)9结合时，BRC4wt缩短了体外DNA复制轨迹长度，并降低了由DNA拓扑异构酶I抑制剂坎普特西汀引起的DNA损伤的同源修复频率，同时也增强了聚(ADP-核糖)聚合酶(PARP)抑制剂奥拉帕尼在HeLa人类宫颈癌细胞和U2OS人类骨肉瘤细胞中诱导的细胞死亡，但在非癌症细胞hTERT RPE-1、MRC-5或MCF-10A中则不然。
T38297	Ribavirin-13C5 Ribavirin-13C5
	Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro...

化合物

DNA polymerase-IN-1

Cat.No: T80644

Target: Antiviral, DNA/RNA Synthesis

Cat.No: T28918

Synonym: Bay 10-8979,HBY 097,Bay10-8979,Bay-108979,Bay108979,Bay 108979,Bay-10-8979

Target: HIV Protease, DNA/RNA Synthesis

Cat.No: T60187

Target: DNA/RNA Synthesis

Cat.No: T14313

Synonym: AVX754,SPD754

Target: HIV Protease, DNA/RNA Synthesis

Cat.No: T3157

Synonym: RNR Inhibitor COH29

Target: DNA/RNA Synthesis

DNA polymerase-IN-3

Cat.No: T79308

Target: DNA/RNA Synthesis

DNA polymerase-IN-2

Cat.No: T79307

Target: DNA/RNA Synthesis

Taq DNA polymerase

Cat.No: T79922

Target: DNA/RNA Synthesis

DNA polymerase-IN-4

Cat.No: T82536

Cat.No: T74108

ddTTP trisodium

Cat.No: T78637

Target: DNA/RNA Synthesis

Cat.No: T28585

Synonym: Ro-31-8588

Cat.No: T81249

Target: PARP

T7 RNA polymerase

Cat.No: T79923

Target: DNA/RNA Synthesis

Cat.No: T28494

Synonym: NSC 637653, 9-Cl-Tibo,R 82913,R82913. 9-Cmbib

Idoxuridine hydrate

Cat.No: T61492

2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)

Cat.No: T37106

Cat.No: T36745

AZT triphosphate TEA

Cat.No: T36490

6(5H)-Phenanthridinone

Cat.No: T72017

Cat.No: T83854

Cat.No: T38297

Synonym: Ribavirin-13C5

Cat. No.	Product Name	Target	Signaling Pathways
T14304	Aphidicolin	Others	Others
	Aphidicolin is a potent inhibitor of cellular deoxyribonucleic acid synthesis and inhibits the growth of herpes simplex virus[2]. Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering with the activity of DNA
T40834	5-Hydroxymethyl-2'-deoxycytidine 5hmdC,2'-脱氧-5-(羟甲基)胞啶	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	5-Hydroxymethyl-2'-deoxycytidine 是 DNA 中 5-methyl-2'-deoxycytidine (5-mdC) 的氧化衍生物，引起DNA损伤反应，染色体畸变，复制叉损伤和细胞活力丧失。5-Hydroxymethyl-2’-deoxycytidine 复制叉不稳定性与染色质上聚（ADP-核糖）聚合酶1（PARP1）的存在有关。
T6S0139	Neobavaisoflavone	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎，抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶，也可抑制血小板聚集。
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Cat.No: T14304

Target: Others

5-Hydroxymethyl-2'-deoxycytidine

Cat.No: T40834

Synonym: 5hmdC,2'-脱氧-5-(羟甲基)胞啶

Target: PARP

Neobavaisoflavone

Cat.No: T6S0139

Target: Apoptosis, DNA/RNA Synthesis

Cat.No: T35779

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼