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Cat. No. | Product Name | Target | Signaling Pathways |
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T2410 |
Nedaplatin
奈达铂,NSC 375101D |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Nedaplatin (NSC-375101D) 是顺铂的衍生物,是肿瘤集落形成单位的 DNA 损伤剂,IC50为94 μM。 | |||
T34628 |
SG3199
SG 3199,SG-3199 |
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SG3199 is a PBD dimer which binds in the minor groove of DNA, and forms covalent DNA interstrand cross-links in naked linear plasmid DNA. SG3199 is potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines. | |||
T68675 |
Porfiromycin
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Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. | |||
T72817 |
Colibactin 742
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Colibactin 742 是一种稳定的大肠杆菌素衍生物,可诱导DNA 链间交联、激活 Fanconi Anemia DNA 修复途径和 G2/M 期阻滞。 | |||
T68942 |
Caricotamide
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Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the prodrug tretazicar, NQO2 converts tretazicar to the bifunctional alkylating agent dinitrobenzamide, which is capable of forming a high degree of DNA interstrand cross-links, resulting in the inhibition of DNA replication and the induction of apoptosis. NQO2 has been found to be over... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T0974 |
Novobiocin Sodium
Albamycinsodium,新生霉素钠,Cathomycin,Albamycin |
Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy | Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology |
Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。 它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。 | |||
T4558 |
Trioxsalen
三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen |
DNA Alkylator/Crosslinker; DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Trioxsalen (Trioxysalen) 是一种呋喃香豆素和补骨脂素衍生物,与 UV-A 一起用于光疗治疗白癜风和手部湿疹。它是一种光化学 DNA 交联剂,可用于激光激活定位的基因组链间交联可视化。 |