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5

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T39527 Se-DMC

Se-DMC effectively reduces the inflammatory response, nociception, and neurobehavioral deficits induced by complete Freund's adjuvant (CFA) in mice.
T11061 DMCM hydrochloride

GABA Receptor Membrane transporter/Ion channel; Neuroscience
DMCM hydrochloride 是一种苯二氮杂 (benzodiazepine) 非选择性全反向激动剂。DMCM 对人重组 GABAA αxβ3γ2 受体亚型具有亲和力,对 α1,α2,α3 和 α5 受体的 Ki 值分别为 10 nM,13 nM,7.5 nM,2.2 nM。
T8550 NDMC101

Others; NF-κB; Proteasome NF-κB; Others; Proteases/Proteasome; Ubiquitination
NDMC101 是有效的破骨细胞形成抑制剂,通过下调 NFATc1 调控基因表达抑制破骨细胞分化。它与 DPP4底物相似,通过抑制DPP4抑制早期 T 细胞激活。它能够用于骨疾病的研究,如类风湿关节炎、滑膜炎等。
T13657 dMCL1-2

Others Others
dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, which binds to MCL1 with a KD of 30 nM. dmcl-2 activates the apoptosis mechanism by degrading MCL1.
T35610 2,5-dimethyl Celecoxib

Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂,mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。

化合物

Se-DMC
Cat.No: T39527
Synonym:
Target:
DMCM hydrochloride
Cat.No: T11061
Synonym:
Target: GABA Receptor
NDMC101
Cat.No: T8550
Synonym:
Target: Others, NF-κB, Proteasome
dMCL1-2
Cat.No: T13657
Synonym:
Target: Others
2,5-dimethyl Celecoxib
Cat.No: T35610
Synonym:
Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor
Cat. No. Product Name Species Expression System
TMPY-04984 CXCL17 Protein, Human, Recombinant (His)

Dcip1,UNQ473,DMC,VCC1,chemokine (C-X-C motif) ligan...

Human P. pastoris (Yeast)
Chemokine (C-X-C motif) ligand 17 (CXCL17) is the latest member of the chemokine family. CXCL17 is a potential oncogene and promising therapeutic target, is an independent biomarker of poor prognosis in patients with breast cancer, and can promote proliferation and migration of breast cancer cells in vitro and in vivo. CXCL17 is expressed in a variety of cancers and promotes tumor progression by recruiting myeloid-derived suppressor cells (MDSCs). CXCL17 attenuates IMQ-induced psoriasis-like ski...

重组蛋白

CXCL17 Protein, Human, Recombinant (His)
Cat.No: TMPY-04984
Species: Human
Expression System: P. pastoris (Yeast)
TargetMol Loading
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