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Search Results for " cytochrome p450 2c9 "

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T25283	Cytochrome P450 2C9 Cyp2C9,Human cytochrome P450 2C9,Cytochrome P 450 2C9,S-Mephenytoin 4-hydroxylase
	Cytochrome P450 2C9 is a cytochrome P-450 subtype that possesses specificity for acidic xenobiotics. It oxidizes a wide range of important clinical drugs under the categories of nonsteroidal anti-inflammatory agents, anticoagulants, hypoglycemic agents, a
T1743	Aprepitant MK-869,MK-0869,阿瑞匹坦,L-754030,Aprepitant`	HIV Protease; Antibacterial; Antibiotic; Neurokinin receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Aprepitant (Aprepitant`) 是选择性和高亲和力的神经激肽1受体拮抗剂，Kd 值为86 pM。
T2393	Efavirenz EFV,依非韦伦,DMP 266,依法韦仑,Sustiva,Stocrin,L-743726	HIV Protease; Reverse Transcriptase; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Efavirenz (DMP 266) 是一种人类免疫缺陷病毒 1 非核苷类似物逆转录酶抑制剂。它也是一种野生型HIV-1 RT 抑制剂，Ki 为 2.93 nM，有效抑制 HIV-1 复制，IC95为 1.5 nM。
T2332	Elvitegravir 埃替格韦,GS-9137,EVG,D06677,JTK-303	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Elvitegravir (JTK-303) 是一种人类免疫缺陷病毒整合酶链转移抑制剂，作用于 HIV-1IIIB、HIV-2EHO 和 HIV-2ROD，IC50分别为 0.7 nM、2.8 nM 和 1.4 nM。
T0885	Sulfamethoxazole Ro 4-2130,STX 608,磺胺甲恶唑	Antibacterial; Antibiotic; Autophagy	Autophagy; Microbiology/Virology
	Sulfamethoxazole (STX 608) 是磺胺类抗菌素，用于细菌感染。Sulfonamides 是对氨基苯甲酸的竞争性拮抗剂。
T39371	LKY-047
	LKY-047, a derivative of Decursin, is a highly effective and specific reversible competitive inhibitor of cytochrome P45022J2 (CYP2J2), with an IC 50 value of 1.7 μM. LKY-047 does not display inhibitory activity against other human P450 enzymes including CYPs 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A.
T40654	Avatrombopag hydrochloride AKR-501 hydrochloride,YM477hydrochloride,E5501hydrochloride
	Avatrombopag hydrochloride (AKR-501) is an orally active, nonpeptide agonist of the thrombopoietin (TPO) receptor with an EC 50 of 3.3 nM. It effectively mimics the biological activities of TPO, stimulating platelet production by activating the intracellular signaling system and facilitating the generation of platelets and megakaryocytes from hemopoietic precursor cells. Additionally, Avatrombopag hydrochloride serves as a substrate for cytochrome P450 (CYP) 2C9 and CYP3A.

化合物

Cytochrome P450 2C9

Cat.No: T25283

Synonym: Cyp2C9,Human cytochrome P450 2C9,Cytochrome P 450 2C9,S-Mephenytoin 4-hydroxylase

Target:

Aprepitant

Cat.No: T1743

Synonym: MK-869,MK-0869,阿瑞匹坦,L-754030,Aprepitant`

Target: HIV Protease, Antibacterial, Antibiotic, Neurokinin receptor

Efavirenz

Cat.No: T2393

Synonym: EFV,依非韦伦,DMP 266,依法韦仑,Sustiva,Stocrin,L-743726

Target: HIV Protease, Reverse Transcriptase, Autophagy

Elvitegravir

Cat.No: T2332

Synonym: 埃替格韦,GS-9137,EVG,D06677,JTK-303

Target: HIV Protease

Sulfamethoxazole

Cat.No: T0885

Synonym: Ro 4-2130,STX 608,磺胺甲恶唑

Target: Antibacterial, Antibiotic, Autophagy

Avatrombopag hydrochloride

Cat.No: T40654

Synonym: AKR-501 hydrochloride,YM477hydrochloride,E5501hydrochloride

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T6S1894	Linderane	P450	Metabolism
	Linderane 分离自 Lindera strychnifolia，能够不可逆的抑制 cytochrome P450 2C9。它具有抗痉挛及缓解疼痛的功能。
T2940	6-Hydroxyflavone 6-羟基黄酮,6-HF	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	6-Hydroxyflavone (6-HF) 是天然存在的黄酮化合物，具有抗炎作用。它对牛血红蛋白糖基化具有抑制作用。它能激活 AKT、ERK 1/2、JNK 信号通路，有效促进成骨细胞分化。它能抑制 LPS 诱导的 NO 的产生。

天然产物

Synonym: 6-羟基黄酮,6-HF

Target: GABA Receptor

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