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46

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35349	CU-CPD107 CU-CPD107	TLR	Immunology/Inflammation
	CU-CPD107是一种 toll-like receptor 8 （TLR8）的选择性激动剂，对ssRNA 配体也表现出激活活性。在R848存在的情况下，CU-CPD107是TLR8信号抑制剂 (IC50=13.7 μM)。在ssRNA 存在的情况下，CU-CPD107表现出协同激动剂活性，而CU-CPD107单独不影响TLR8信号转导。
T10899	CU-CPT17e	TLR	Immunology/Inflammation
	CU-CPT17e 是多Toll 样受体激动剂，可激活TLR3、TLR8和TLR9。
T15020	CU-CPT22	TLR	Immunology/Inflammation
	CU-CPT22 是 toll 样受体 1 和 2 蛋白复合物抑制剂，可阻断 Pam3CSK4诱导的 TLR1/2 激活，IC50值为 0.58 µM。它与 TLR1/2 结合的合成三酰脂蛋白竞争，Ki 值为 0.41 µM。
T7302	CU-CPT9b CU-CPT-9b,TLR8-specific antagonist 1	TLR	Immunology/Inflammation
	CU-CPT9b (TLR8-specific antagonist 1) 是 toll 样受体 8 (TLR8) 的拮抗剂，Kd 为 21 nM。它抑制由 TLR8 激动剂 R-848 在过表达 TLR8 的 HEK-Blue 细胞中诱导的 NF-ĸB 活化，IC50 值为 0.7 nM。
T15017	CU-T12-9	TLR	Immunology/Inflammation
	CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。
T9645	CU-115 N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide	TLR	Immunology/Inflammation
	CU-115 是一种有效的，选择性的 TLR8 拮抗剂。CU-115对 TLR8 和 TLR7的 IC50分别为1.04 µM 和=>50 µM。THP-1 细胞中，CU-115 减少了 R-848 激活的 TNF-α 和 IL-1β 的产生。
T7317	CU-CPT-9a	TLR	Immunology/Inflammation
	CU-CPT-9a 是TLR8特异性拮抗剂，IC50值为 0.5 nM。
T7347	CU-CPT-8m TLR8-specific antagonist	TLR	Immunology/Inflammation
	CU-CPT-8m (TLR8-specific antagonist) 是TLR8特异性拮抗剂，IC50值为 67 nM。
T8331	NUN82647 CU-242	Others	Others
	NUN82647 (CU-242) 是 G2 期细胞周期抑制剂和凋亡诱导剂。
T27099	CU-3 CU 3,CU3
	CU-3 is a potent and selective inhibitor of diacylglycerol kinase alpha (DGKalpha). CU-3 attenuates cancer cell proliferation and simultaneously enhances immune responses including anti-cancer immunity.
T38328	CU-32
	CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. 1.Padilla-Salinas...
T38329	CU-76
	CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. 1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP sy...
T69911	CU-6PMN
	CU-6PM is a new fluorescent RXR agonist. CU-6PMN was designed based on the fact that umbelliferone emits strong fluorescence in a hydrophilic environment, but the fluorescence intensity decreases in hydrophobic environments such as the interior of proteins. The developed assay CU-6PMN enabled screening of rexinoids to be performed easily within a few hours by monitoring changes of fluorescence intensity with widely available fluorescence microplate readers, without the need for processes such a...
T22698	TLR3-IN-1 CU CPT 4a	TLR	Immunology/Inflammation
	TLR3-IN-1 (CU CPT 4a) 是一种选择性的TLR3信号抑制剂，在 RAW 264.7 细胞中 IC50 为 3.44 μM。它可以抑制 TLR3/dsRNA 复合物介导的下游信号通路，并抑制全细胞中 TNF-α 和 IL-1β 的产生。
T71601	CU-2010
	CU-2010 is a synthetic serine protease inhibitor with antifibrinolytic and anticoagulant properties. CU-2010 dose-dependently reduces postoperative blood loss and improves postischemic recovery after cardiac surgery in a canine model.
TP1158	Copper tripeptide [N2-(N-甘氨酰-L-组氨酰)-L-赖氨酸]铜,GHK-Cu	Others; Endogenous Metabolite	Metabolism; Others
	Copper tripeptide (GHK-Cu) 是天然存在的三肽，首先从人血浆中分离，但也能够在唾液和尿液中发现。它能够提高成纤维细胞中胶原蛋白，弹性蛋白，蛋白多糖和糖胺聚糖中信使 RNA 的产生。在伤口愈合期间，它能够通过蛋白水解从现有的细胞外蛋白质中除去，并且用作炎性和内皮细胞的化学引诱物。它是皮肤再生中多种细胞途径的天然调节剂。
T40792	Cu(II)GTSM
	Cu(II)GTSM, a cell-permeable copper-complex, effectively inhibits GSK3β and shows inhibitory effects against Amyloid-β oligomers (AβOs) while reducing tau phosphorylation. Additionally, Cu(II)GTSM decreases the abundance of Amyloid-β trimers. With its potential as an anticancer and antimicrobial agent, Cu(II)GTSM exhibits promising therapeutic capabilities.
T10177	(5Z,2E)-CU-3	Apoptosis	Apoptosis
	(5Z,2E)-CU-3 是一种具有有效性和选择性的 DGKα 同工酶抑制剂，IC50 值为 0.6 μM，通过对竞争ATP来抑制 DGKα，Km 值为 0.48 mM。(5Z,2E)-CU-3 具有选择性，靶向 DGKα 催化区域，但不作用于调节区域。(5Z,2E)-CU-3 具有抗肿瘤和免疫原性作用，促进癌细胞的凋亡和 T 细胞的活化。
T38935	Cu(II) protoporphyrin IX
	Cu (II) Protoporphyrin IX functions as a negative control for Zn (II) Protoporphyrin, a heme oxygenase inhibitor. Heme oxygenase is involved in tumor cell resistance to chemotherapy and the regulation of free radical formation, inflammation, and vascular repair.
T71715	CU239
	CU239 is a selective non-retinoid inhibitor of RPE65 which suppresses visual cycle and prevents retinal degeneration.
T16689	Pyranine 溶剂绿7,HPTS,Solvent Green 7	Others	Others
	Pyranine (Solvent Green 7) 是一类用于 Cu+离子的荧光化学传感器 (λex=450 nm，λem=510 nm)，是 pH 敏感的荧光指示剂。
T82681	Copper tripeptide-3 AHK-Cu
	AHK-Cu 是一种生物活性肽，具促进毛发生长功能，已作为化妆品成分使用。
T2686	Esomeprazole Magnesium (S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium	ATPase; Proton pump	Membrane transporter/Ion channel
	Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T71599	AqB007
	AqB007 is a selective blocker of the Aquaporin-1 ion channel conductance, thereby slowing cancer cell migration.
T7714	Temocapil	Tyrosinase	Proteases/Proteasome
	Temocapil 是一种酪氨酸激酶抑制剂。
T69910	EML631
	EML631 is a potent and selective SPIN1 inhibitor (SPIN1 Kd= 3 microM).
T78987	SA09-Cu
	SA09-Cu是一种NDM-1的非竞争性抑制剂，具有9.6 nM的IC50。该化合物通过作用于氧化酶的Zn(II)-硫醇盐位点，能将NDM-1转化为无活性形态，从而抵御细菌细胞内的硫醇还原作用。SA09-Cu对于多种产生NDM-1的肠杆菌科碳青霉烯耐药菌株（CRE）表现出明显的抑制作用，有效恢复了美罗培南的活性，并有助于减缓碳青霉烯耐药性的进展。
T8386	Esomeprazole Magnesium trihydrate 埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate	Proton pump	Membrane transporter/Ion channel
	Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种口服有效的H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病的研究中具有价值。它是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T6698	Temocapril hydrochloride CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利	RAAS	Endocrinology/Hormones
	Temocapril hydrochloride (CS-622 HCl) 是血管紧张素转化酶 (ACE) 抑制剂。Temocapril HCl 能够用于充血性心力衰竭、急性心肌梗死、高血压、胰岛素抵抗和肾脏疾病的研究。
T65816	Prolyl-4-hydroxylase Inhibitor 11	Others	Others
	Prolyl-4-hydroxylase Inhibitor 11 是一种新型脯氨酸4-羟化酶抑制剂，对普通小球藻(Chlorella vulgaris)氧化应激和 Cu(II)毒性的保护作用。
TQ0013	BTTAA	Others	Others
	BTTAA 是 Cu(I)-稳定配体，能够的有效与泛素 Glu18AzF 反应。
T40996	Coppersensor 1 Coppersensor 1,CS1	Others	Others
	Coppersensor 1 (CS1) 是一种基于硼二吡咯亚甲基的荧光传感器，用于选择性和灵敏地检测生物样品中的铜 (I) 离子 (Cu + )。 Coppersensor 1 可以使用任何类型的荧光显微镜进行成像，包括落射荧光、共焦和多光子。
T16730	Remibrutinib	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Remibrutinib 是有效的、口服具有活力的 bruton tyrosine kinase 抑制剂 (IC50:1 nM)，在血液中抑制 BTK 活性的 IC50的值为 0.23 μM。它具有研究慢性荨麻疹的潜力。
T40337	Salpyran
	Salpyran is a Cu(II) selective chelator with therapeutic potential.
T26002	Pyclen
	Pyclen is an inhibitor of cell death induced by oxidative stress and an inhibitor of AB1-40 aggregation induced by Cu2+ ion. It can both prevent and disrupt Cu(2+) induced AB(1-40) aggregation.
T70504	6,8-Diprenyleriodictyol
	6,8-Diprenyleriodictyol is an antioxidant, which inhibits Cu(2+)-mediated oxidation of human low density lipoprotein (LDL).
T36499	CuATSM
	The metallo-protein Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals. Mutations in SOD1, which alter its metal binding capacity and can result in protein misfolding and aggregation, have been linked to familial amyotrophic lateral sclerosis (ALS). Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that has traditionally been used in cellular imaging experiments to selectively label hypoxic tissue via its susceptibility ...
T34492	Salinazid Nilazid,Salicylaldehyde isonicotinoyl hydrazone,Salizid,Salizide,Nupasal,SIH1	Others	Others
	Salinazid (Salicylaldehyde isonicotinoyl hydrazone) 是一种有效的抗结核药。
T20382	Diglycyl-histidine NSC334195,NSC-334195,Gly-gly-his,Glycylglycyl-L-histidine,NSC 334195
	Diglycyl-histidine is a tripeptide complexed with cupric ion designed to mimic specific Cu(II) transport site of ascorbate on albumin molecule.
T81223	Salpyran hydrochloride
	Salpyran作为一种铜（II）选择性螯合剂，展现出研究潜力。
T82790	CalFluor 488 Azide
	CalFluor 488 Azide 为水溶性叠氮化物荧光探针，通过Cu催化或无金属点击化学反应进行活化，而在与炔烃反应前不显示荧光性。
T82383	Fmoc-Lys(5-FITC)-OH
	Fmoc-Lys(5-FITC)-OH 作为一种荧光探针，广泛应用于多肽或蛋白质的胺标记。其荧光组分FITC对pH和Cu2+具有敏感性，是实验中常用的荧光染料。
T79577	CB2 PET Radioligand 1	Cannabinoid Receptor	GPCR/G Protein
	CB2PET Radioligand 1 (compound [18F]9) 作为hCB2靶向的PET Radioligand (Ki=7.7 nM)，采用Cu介导的18F-氟化方法制备，并在小鼠神经炎症模型中展现了高脑摄取率。
T35378	Iron (III) hexacyanoferrate (II) Prussian Blue,Berlin blue,Iron (III) hexacyanoferrate (II)	Others	Others
	Iron (III) hexacyanoferrate (II) (Prussian Blue, Berlin blue) 用作吸附剂，用于有效去除水溶液中的重金属（Cu (II)、Co (II)、Ni (II) 和 Pb (II)）。
T82867	Biotin-PEG-azide (MW 3400)
	Biotin-PEG-azide (MW 3400) 是带有高特异性生物素标记的 PEG 链端修饰化合物。该分子中包含的生物素成分适用于针对性蛋白质标记，而 PEG 作为低毒且亲水的聚合物，增加了分子的水溶性及生物相容性。末端叠氮基团，则能在铜催化的“点击化学”反应中快速与炔烃结合，有效提升生物素与目标分子的结合效率。
T72763	AChE/BuChE-IN-1
	AChE/BuChE-IN-1，一种白杨素衍生物，具备对丁酰胆碱酯酶（BuChE）的选择性抑制作用，其IC50值为0.48μM。对乙酰胆碱酯酶（AChE）的抑制IC50值为7.16μM。该化合物强效清除·OH，IC50仅为0.1674μM，能够抑制活性氧（ROS）、阻止Aβ1-42的聚集（自发、Cu2+诱导及AChE诱导）。AChE/BuChE-IN-1展现出高血脑屏障（BBB）渗透性、优良的生物利用度和低细胞毒性，是阿尔茨海默病（AD）研究领域的有力候选。

化合物

Cat.No: T35349

Synonym: CU-CPD107

Target: TLR

Cat.No: T10899

Target: TLR

Cat.No: T15020

Target: TLR

Cat.No: T7302

Synonym: CU-CPT-9b,TLR8-specific antagonist 1

Target: TLR

Cat.No: T15017

Target: TLR

Cat.No: T9645

Synonym: N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide

Target: TLR

Cat.No: T7317

Target: TLR

Cat.No: T7347

Synonym: TLR8-specific antagonist

Target: TLR

Cat.No: T8331

Synonym: CU-242

Target: Others

Cat.No: T27099

Synonym: CU 3,CU3

Cat.No: T38328

Cat.No: T38329

Cat.No: T69911

Cat.No: T22698

Synonym: CU CPT 4a

Target: TLR

Cat.No: T71601

Copper tripeptide

Cat.No: TP1158

Synonym: [N2-(N-甘氨酰-L-组氨酰)-L-赖氨酸]铜,GHK-Cu

Target: Others, Endogenous Metabolite

Cat.No: T40792

Cat.No: T10177

Target: Apoptosis

Cu(II) protoporphyrin IX

Cat.No: T38935

Cat.No: T71715

Cat.No: T16689

Synonym: 溶剂绿7,HPTS,Solvent Green 7

Target: Others

Copper tripeptide-3

Cat.No: T82681

Synonym: AHK-Cu

Esomeprazole Magnesium

Cat.No: T2686

Synonym: (S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium

Target: ATPase, Proton pump

Cat.No: T71599

Cat.No: T7714

Target: Tyrosinase

Cat.No: T69910

Cat.No: T78987

Esomeprazole Magnesium trihydrate

Cat.No: T8386

Synonym: 埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate

Target: Proton pump

Temocapril hydrochloride

Cat.No: T6698

Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利

Target: RAAS

Prolyl-4-hydroxylase Inhibitor 11

Cat.No: T65816

Target: Others

Cat.No: TQ0013

Target: Others

Cat.No: T40996

Synonym: Coppersensor 1,CS1

Target: Others

Cat.No: T16730

Target: BTK

Cat.No: T40337

Cat.No: T26002

6,8-Diprenyleriodictyol

Cat.No: T70504

Cat.No: T36499

Cat.No: T34492

Synonym: Nilazid,Salicylaldehyde isonicotinoyl hydrazone,Salizid,Salizide,Nupasal,SIH1

Target: Others

Diglycyl-histidine

Cat.No: T20382

Synonym: NSC334195,NSC-334195,Gly-gly-his,Glycylglycyl-L-histidine,NSC 334195

Salpyran hydrochloride

Cat.No: T81223

CalFluor 488 Azide

Cat.No: T82790

Fmoc-Lys(5-FITC)-OH

Cat.No: T82383

CB2 PET Radioligand 1

Cat.No: T79577

Target: Cannabinoid Receptor

Iron (III) hexacyanoferrate (II)

Cat.No: T35378

Synonym: Prussian Blue,Berlin blue,Iron (III) hexacyanoferrate (II)

Target: Others

Biotin-PEG-azide (MW 3400)

Cat.No: T82867

AChE/BuChE-IN-1

Cat.No: T72763

Cat. No.	Product Name	Target	Signaling Pathways
T77563	4-Ethylcatechol	DNA	DNA Damage/DNA Repair
	4-Ethylcatechol 存在于红葡萄酒中，可从Glechoma longituba（NaKai）Kupr 中提取。4-Ethylcatechol 在Cu（II）存在下会引起DNA 损伤。4-Ethylcatechol 是一种高效的抗血小板化合物。
T4916	D-Glucaric acid potassium D-Saccharic acid potassium salt,Glucosaccharic acid,D-葡萄糖二酸单钾盐,Glucaric Acid	Others; Endogenous Metabolite	Metabolism; Others
	D-Glucaric acid potassium (D-Saccharic acid potassium salt) 是内源性代谢产物的一种。
TN1003	DL-Alanine DL-2-Aminopropionic acid	Endogenous Metabolite	Metabolism
	DL-Alanine (DL-2-Aminopropionic acid) 是一种氨基酸，是L-和D-丙氨酸的外消旋化合物。DL-Alanine 与硝酸银水溶液一起用于纳米颗粒生成时常作为还原剂和封端剂。DL-Alanine 是一种甜味剂，可把它位与甘氨酸和糖精钠归为一类。DL-Alanine 在组织和肝脏之间的葡萄糖-丙氨酸循环中起重要作用。DL-Alanine 可用于研究 Cu、Zn、Cd 等过渡金属螯合。
T5S1172	Tiliroside 银椴甙,Tribuloside,银椴苷；椴树苷	Antioxidant	oxidation-reduction
	Tiliroside (Tribuloside) 是糖苷类黄酮，是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收，具有抗糖尿病作用。
T38557	Chitotriose trihydrochloride
	Chitotriose trihydrochloride is an orally active chitooligosaccharide known for its antioxidant properties. It effectively inhibits the hydroxylation of benzoate to salicylate by H 2 O 2 in the presence of Cu 2+, with an IC 50 value of 80 μM.

天然产物

4-Ethylcatechol

Cat.No: T77563

Target: DNA

D-Glucaric acid potassium

Cat.No: T4916

Synonym: D-Saccharic acid potassium salt,Glucosaccharic acid,D-葡萄糖二酸单钾盐,Glucaric Acid

Target: Others, Endogenous Metabolite

Cat.No: TN1003

Synonym: DL-2-Aminopropionic acid

Target: Endogenous Metabolite

Cat.No: T5S1172

Synonym: 银椴甙,Tribuloside,银椴苷；椴树苷

Target: Antioxidant

Chitotriose trihydrochloride

Cat.No: T38557

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