Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Prolyl-4-hydroxylase Inhibitor 11 是一种新型脯氨酸4-羟化酶抑制剂,对普通小球藻(Chlorella vulgaris)氧化应激和 Cu(II)毒性的保护作用。
产品描述 | Prolyl-4-hydroxylase Inhibitor 11, a novel proline 4-hydroxylase inhibitor, shows protective effects against oxidative stress and Cu(II) toxicity in Chlorella vulgaris. |
靶点活性 | Prolyl hydroxylase:0.19 microM |
体外活性 |
In this study, we evaluated the role of 2,2'-bipyridine-5,5'-dicarboxylic acid (Bpy-COOH) in protecting Chlorella vulgaris from the oxidative stress and toxicity induced by Cu(II). In vitro tests indicated that peroxidase-like complexes could be formed between Bpy-COOH and Cu(II). It could be concluded that the use of Bpy-COOH could significantly decrease Cu(II) toxicity to algal cells by forming peroxidase-like complexes.[1] Members of a series of 2,2'-bipyridines have been synthesized and tested as inhibitors of prolyl hydroxylase. [2,2'-bipyridine]-5,5'-dicarboxylic acid (IC50 = 0.19 microM) is the most potent inhibitor of its type yet reported.[2] |
体内活性 | In this study, we evaluated the role of 2,2'-bipyridine-5,5'-dicarboxylic acid (Bpy-COOH) in protecting Chlorella vulgaris from the oxidative stress and toxicity induced by Cu(II). The in vivo experiments showed that the production of reactive oxygen species in C. pyrenoidosa treated by the addition of Bpy-COOH and Cu(II) in three orders were all significantly less than that in cases treated with only Cu(II).[1] |
分子量 | 244.2 |
分子式 | C12H8N2O4 |
CAS No. | 1802-30-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1mg/ml, Sonication is recommended.
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Prolyl-4-hydroxylase Inhibitor 11 1802-30-8 Others Inhibitor inhibitor inhibit