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Search Results for " coumarin 7 "

15

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T37926	7-Ethoxy-4-(trifluoromethyl)coumarin
	7-Ethoxy-5-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P450s (CYPs).1Upon O-deethylation by CYPs, 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) is released and its fluorescence can be used to quantify CYP activity. HFC displays excitation/emission maxima of 410/510 nm, respectively. 1.Buters, J.T.M., Schiller, C.D., and Chou, R.C.A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man. Direct fluorescence monitoring of the deethylation o...
T37365	7-hydroxy Coumarin sulfate (potassium salt)
	7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS.
T37364	7-hydroxy Coumarin Glucuronide (sodium salt)
	7-hydroxy Coumarin glucuronide is a 7-hydroxy coumarin phase II metabolite that can be used as a standard for the analysis of 7-hydroxy coumarin metabolism.
T5845	7ACC1 DEAC,香豆素D1421,Coumarin D 1421,7-(二乙胺基）-2-氧代-2-苯并吡喃-3-羧酸,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421	Monocarboxylate transporter	Membrane transporter/Ion channel
	7ACC1 (D 142) 抑制表达MCT1和MCT4肿瘤细胞的乳酸涌入，能选择性干扰肿瘤微环境乳酸通量。
T117521	7-BFC 7-Benzyloxy-4-(trifluoromethyl)coumarin,Y040-0031	P450	Metabolism
	7-BFC (7-Benzyloxy-4-(trifluoromethyl)coumarin) 是一种香豆素类荧光底物，可作为细胞色素 P 450 的生物标记物，可用于研究 CYP 亚型和细胞色素 P 450 代谢。
T77674	3-Cyano-7-hydroxycoumarin 3-Cyanoumbelliferone
	3-Cyano-7-hydroxycoumarin (3-Cyanoumbelliferone) 是一种巨噬细胞游走抑制因子 (MIF) 互变异构酶抑制剂，Ki 为 2.9 μM。3-Cyano-7-hydroxycoumarin 属于香豆素衍生物，可被用作分子探针和荧光染料。
TD0078	Succinimidyl 7-methoxycoumarin-3-carboxylate 7-甲氧基-3-羧基香豆素琥珀酰亚胺酯,7-Methoxycoumarin-3-carboxylic acid, succinimidyl ester
	7-Methoxycoumarin-3-carboxylic acid may be used as a reference compound in the purification, separation and analysis of coumarin compounds.
T38325	Coumarin Boronic Acid pinacolate ester
	Coumarin boronic acid pinacolate ester (CBE) is a more soluble form of coumarin boronic acid that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide. Peroxynitrite oxidizes CBE into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively.
TD0074	N-Succinimidyl 7-hydroxycoumarin-3-carboxylate 7-羟基-3-羧基香豆素琥珀酰亚胺酯,7-Hydroxycoumarin-3-carboxylic acid, succinimidyl ester
	7-Hydroxycoumarin-3-carboxylic acid, SE is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. This coumarin is also increasingly used to label peptides, nucleotides and carbohydrates.
TD0075	7-Hydroxy-4-methylcoumarin-3-acetic acid
	7-Hydroxy-4-methylcoumarin-3-acetic acid is a blue fluorophore that has pH-dependent and environment-sensitive fluorescence. This coumarin is increasingly used to label peptides, nucleotides and carbohydrates.
T83256	7-(Dimethylamino)-4-methylcoumarin
	7-(Dimethylamino)-4-methylcoumarin，一种香豆素，主要用于香豆素荧光增白剂溶液研究。
T37000	7-Azido-4-methylcoumarin
	7-Azido-4-methylcoumarin (AzMC) is a coumarin fluorescent probe for hydrogen sulfide (H2S).1 AzMC selectively fluoresces in the presence of H2S over a panel of reactive nitrogen, oxygen, and sulfur species. AzMC displays excitation/emission maxima of 340/445 nm, respectively. \|1. Chen, B., Li, W., Lv, C., et al. Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues. Analyst 138(3), 946-951 (2013).
T38324	Coumarin Boronic Acid
	Coumarin boronic acid (CBA) is a fluorescent probe that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide.It reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM/s) than hydrogen peroxide (k =1.5 M/s) and moderately faster rate than hypochlorous acid. Peroxynitrite oxidizes CBA into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively.
T36105	coumarin-SAHA coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA
	Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm
T78135	Nicotelline Nicotellin
	Nicotelline（Nicotellin）是一种与尼古丁相关的生物碱，作为人类cDNA表达的细胞色素P-450 2A6（CYP2A6）的弱抑制剂，不显著抑制该酶介导的香豆素7-羟基化反应，在300 μM浓度下效果更是如此。此外，Nicotelline还被用作烟草烟雾中颗粒物（PM）的示踪剂和生物标记物。

化合物

7-Ethoxy-4-(trifluoromethyl)coumarin

Cat.No: T37926

7-hydroxy Coumarin sulfate (potassium salt)

Cat.No: T37365

7-hydroxy Coumarin Glucuronide (sodium salt)

Cat.No: T37364

Cat.No: T5845

Synonym: DEAC,香豆素D1421,Coumarin D 1421,7-(二乙胺基）-2-氧代-2-苯并吡喃-3-羧酸,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421

Target: Monocarboxylate transporter

Cat.No: T117521

Synonym: 7-Benzyloxy-4-(trifluoromethyl)coumarin,Y040-0031

Target: P450

3-Cyano-7-hydroxycoumarin

Cat.No: T77674

Synonym: 3-Cyanoumbelliferone

Succinimidyl 7-methoxycoumarin-3-carboxylate

Cat.No: TD0078

Synonym: 7-甲氧基-3-羧基香豆素琥珀酰亚胺酯,7-Methoxycoumarin-3-carboxylic acid, succinimidyl ester

Coumarin Boronic Acid pinacolate ester

Cat.No: T38325

N-Succinimidyl 7-hydroxycoumarin-3-carboxylate

Cat.No: TD0074

Synonym: 7-羟基-3-羧基香豆素琥珀酰亚胺酯,7-Hydroxycoumarin-3-carboxylic acid, succinimidyl ester

7-Hydroxy-4-methylcoumarin-3-acetic acid

Cat.No: TD0075

7-(Dimethylamino)-4-methylcoumarin

Cat.No: T83256

7-Azido-4-methylcoumarin

Cat.No: T37000

Coumarin Boronic Acid

Cat.No: T38324

coumarin-SAHA

Cat.No: T36105

Synonym: coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA

Cat.No: T78135

Synonym: Nicotellin

Cat. No.	Product Name	Target	Signaling Pathways
T7960	Coumarin 7 香豆素-7,香豆素7	Others	Others
	Coumarin 7 是一种在植物中以糖苷的形式存在的香豆素激光染料。
TJS0341	7-Amino-4-(trifluoromethyl)coumarin 香豆素151,Coumarin 151,AFC,7-氨基-4-（三氟甲基）香豆素	5-HT Receptor	GPCR/G Protein; Neuroscience
	7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) 是一种荧光标记物，其激发和发射波长分别为400和500 nm，可用来灵敏的检测蛋白酶。
TN6209	7-(3'-Carboxybutoxy)coumarin
	7-(3'-Carboxybutoxy)coumarin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6209，CAS号为 16851-01-7。
T7934	7-Methylcoumarin	Others	Others
	7-Methylcoumarin 具有很强的保肝活性。
TN6207	7-(6'R-hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)coumarin
	7-(6'R-hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)coumarin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6207，CAS号为 118584-19-3。
T8038	7-Ethoxy-4-Methylcoumarin	Others	Others
	7-Ethoxy-4-Methylcoumarin 具有独特气味的芳香化合物。它被认为是细胞中酶的抑制剂，已被用于酶抑制的研究，并已被用于研究各种药物对人体的影响。
TN1328	7-Amino-4-methylcoumarin-3-acetic acid 7-氨基-4-甲基-3-香豆素醋酸,7-Amino-4-methylcoumarin	Others	Others
	7-Amino-4-methylcoumarin-3-acetic acid (7-Amino-4-methylcoumarin) 是荧光蛋白质标记剂，能够被紫外光(350 nm) 激活，可在蓝色区域 (440-460 nm) 发光。
TJS0312	7-hydroxy-4-methyl-8-nitrocoumarin	Others	Others
	7-Hydroxy-4-methyl-8-nitrocoumarin 是香豆素衍生物的一种。
T5774	Demethylsuberosin 7-去甲基软木花椒素,7-demethylsuberosin	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	7-Demethylsuberosin (7-demethylsuberosin) 是一种分离自 Angelica gigasNakai 中的香豆素类化合物，具有抗炎作用。
T2785	4-Methylherniarin 羟甲香豆素甲醚,7-Methoxy-4-methylcoumarin	Others; Antibacterial	Microbiology/Virology; Others
	4-Methylherniarin (7-Methoxy-4-methylcoumarin) 可荧光标记，是香豆素衍生物，具有抗革兰氏阳性和革兰氏阴性细菌染色的活性。它对B. subtilis 和S.sonnei 有活性，IC50值为 11.76 μg/ml 和 13.47 μg/ml。
T4115	Auraptene 橙皮油内酯,7-geranyloxycoumarin,橙皮油素	MMP; BACE	Neuroscience; Proteases/Proteasome
	Auraptene 是一种丰富的天然香叶氧基香豆素。它能够抑制基质金属蛋白酶 2 以及关键炎症因子，包括 IL-6，IL-8 和趋化因子 (C-C 基序) 配体-5 (CCL5）的分泌。
T83521	(S)-7-O-Methylpeucedanol 3′-O-β-D-glucopyranoside
	(S)-7-O-Methylpeucedanol 3'-O-β-D-glucopyranoside 为一种香豆素糖苷[sup][1]。
T10195	7-O-Geranylscopoletin 7-Geranyloxy-6-methoxycoumarin	Others	Others
	7-O-Geranylscopoletin is a natural coumarin from the root of Atalantia monophylla. Various parts of this plant have been used for folk medicine for several purposes such as the treatment of chronic rheumatism, antispasmodic, paralysis, hemiplegia, and sti

天然产物

Cat.No: T7960

Synonym: 香豆素-7,香豆素7

Target: Others

7-Amino-4-(trifluoromethyl)coumarin

Cat.No: TJS0341

Synonym: 香豆素151,Coumarin 151,AFC,7-氨基-4-（三氟甲基）香豆素

Target: 5-HT Receptor

7-(3'-Carboxybutoxy)coumarin

Cat.No: TN6209

7-Methylcoumarin

Cat.No: T7934

Target: Others

7-(6'R-hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)coumarin

Cat.No: TN6207

7-Ethoxy-4-Methylcoumarin

Cat.No: T8038

Target: Others

7-Amino-4-methylcoumarin-3-acetic acid

Cat.No: TN1328

Synonym: 7-氨基-4-甲基-3-香豆素醋酸,7-Amino-4-methylcoumarin

Target: Others

7-hydroxy-4-methyl-8-nitrocoumarin

Cat.No: TJS0312

Target: Others

Demethylsuberosin

Cat.No: T5774

Synonym: 7-去甲基软木花椒素,7-demethylsuberosin

Target: Prostaglandin Receptor

4-Methylherniarin

Cat.No: T2785

Synonym: 羟甲香豆素甲醚,7-Methoxy-4-methylcoumarin

Target: Others, Antibacterial

Cat.No: T4115

Synonym: 橙皮油内酯,7-geranyloxycoumarin,橙皮油素

Target: MMP, BACE

(S)-7-O-Methylpeucedanol 3′-O-β-D-glucopyranoside

Cat.No: T83521

7-O-Geranylscopoletin

Cat.No: T10195

Synonym: 7-Geranyloxy-6-methoxycoumarin

Target: Others

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