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25

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0270	Hydrocortisone 17-butyrate 丁酸氢化可的松,Cortisol 17-butyrate,Hydrocortisone butyrate	Glucocorticoid Receptor; Annexin A; Adrenergic Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Hydrocortisone 17-butyrate (Cortisol 17-butyrate) 是一种肾上腺皮质激素类药物。
T75683	Cortisol sulfate sodium
	Cortisol sulfate sodium (Cortisol 21-sulfate) 是皮质醇的一种代谢物。Cortisol sulfate sodium 是细胞内运皮质激素蛋白的一种特异性配体。
TP1031	Tetracosactide Tetracosactrin,替可克肽	Others	Others
	Tetracosactide (Tetracosactrin) 是一种肾上腺皮质激素 (ACTH) 的类似物，能够刺激肾上腺皮质激素分泌。
T35664	Tetracosactide acetate	Others	Others
	Tetracosactide acetate 是一种合成的多肽，可刺激肾上腺释放皮质类固醇，如皮质醇。Tetracosactide acetate 在溃疡性结肠炎和克罗恩病、青少年和成人类风湿性关节炎和骨关节病方面有研究的价值。
T21865	BC 11-38	PDE	Metabolism
	BC 11-38是一种有效的PDE11生物活性抑制剂，可提高PKA 介导的 ATF-1 磷酸化、 H295R 细胞 cAMP 水平和皮质醇生成。
T73794	18-Hydroxycortisol
	18-Hydroxycortisol为肾上腺皮质自然分泌的内源性类固醇，作为皮质醇的衍生物，同时为类固醇生产过程中的一个中间体，主要用于原发性醛固酮增多症（PA）的研究。
T21253	5-alpha-Hydroxy-Laxogenin	Others	Others
	5-alpha-Hydroxy-Laxogenin 是一种应激激素皮质醇抑制剂。
TP1248L	ACTH 11-24 acetate(4237-93-8 free base) Adrenocorticotropic Hormone (11-24) acetate	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	ACTH 11-24 acetate(4237-93-8 free base) (Adrenocorticotropic Hormone (11-24) acetate) 是促肾上腺皮质激素的片段，可诱导皮质醇释放。 ACTH (11-24) 已被确定为分离的肾上腺细胞中 ACTH (1-39) 和 ACTH (1-10) 的竞争性拮抗剂。
T16510	PF-915275	Dehydrogenase	Metabolism
	PF-915275 是口服有效的人 11β-羟基类固醇脱氢酶1型选择性抑制剂，Ki 为 2.3 nM，在 HEK293 细胞中的EC50为 15 nM 。它对人和猴原代肝细胞中可的松向皮质醇的转化具有剂量依赖性，EC50分别为 20 nM 和 100 nM。
TP1238L	ACTH 1-14 acetate(25696-21-3 free base) Adrenocorticotropic Hormone Fragment 1-14 acetate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	ACTH 1-14 acetate(25696-21-3 free base) (Adrenocorticotropic Hormone Fragment 1-14 acetate) 是促肾上腺皮质激素的片段，可调节皮质醇和雄激素的产生。促肾上腺皮质激素 (ACTH)，也称为促肾上腺皮质激素，由垂体前叶产生和分泌。作为对生物应激的反应，ACTH 是下丘脑-垂体-肾上腺轴的重要组成部分。
TP1237	ACTH (1-14) TFA (25696-21-3 free base) Adrenocorticotropic Hormone Fragment 1-14 (TFA),ACTH (1-14) TFA
	ACTH (1-14) (TFA) is a polypeptide of corticotrophin, which promotes the release of cortisol.
TP1238	ACTH (1-14) ACTH 1-14,Adrenocorticotropic Hormone Fragment 1-14
	ACTH (1-14), a fragment of adrenocorticotropin, governs the production of cortisol and androgens.
TP1248	ACTH (11-24) ACTH 11-24,Adrenocorticotropic Hormone (11-24)
	ACTH (11-24) is a fragment of adrenocorticotrophin, induces cortisol release. ACTH (11-24) has been identified as a competitive antagonist of ACTH (1-39) and ACTH (1-10) in isolated adrenal cells.
T73664	Adrenocorticotropic hormone TFA
	Adrenocorticotropic hormone (ACTH) TFA，是由垂体前叶分泌，用于调节皮质醇和雄激素产生的促肾上腺皮质激素。
T75979	ACTH (11-24) (acetate)
	ACTH (11-24) (acetate) 为促肾上腺皮质激素(ACTH)受体拮抗剂，属于ACTH片段，具有诱导皮质醇释放的功能，适用于中枢神经系统研究。
T25443	FW 34569 FW-34-569,FW34569,FW 34-569,FW-34569,FW34-569
	FW 34569 is an enkephalin analogue. It stimulated growth hormones and prolactin release and inhibited the release of cortisol and LH, while FSH remained unchanged.
T75985	ACTH (1-14) (TFA)
	ACTH (1-14) (TFA) 是促肾上腺皮质激素的多肽片段，后者能够促进皮质醇的释放。
T73663	Adrenocorticotropic hormone
	Adrenocorticotropic hormone (ACTH) 是一种由垂体前叶分泌的促肾上腺皮质激素(tropic hormone)，能够调节皮质醇和雄激素的产生。
T36927	Hydrocortisone phosphate
	Hydrocortisone phosphate is the pharmaceutical term for cortisol, which is a steroid hormone, in the glucocorticoid class of hormones, increases blood sugar through gluconeogenesis, to suppress the immune system, and to aid in the metabolism of fat, protein, and carbohydrate.
T61593	11β-HSD1-IN-6
	11β-HSD1-IN-6 is a potent inhibitor of 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs). These enzymes are responsible for catalyzing the conversion of the active glucocorticoids, corticosterone or cortisol, to their respective inactive forms, 11-dehydrocorticosterone (11-DHC) and cortisone. The compound 11β-HSD1-IN-6 specifically targets and inhibits 11β-HSD-1, effectively modulating the interconversion of these glucocorticoids. [1]
T76595	(Des-His6)-ACTH (1-24) (human, bovine, rat)
	(Des-His6)-ACTH (1-24) (human, bovine, rat) 是促肾上腺皮质激素 (ACTH) 的类似物。ACTH 是一种由垂体前叶腺产生的多肽激素，调节皮质醇和雄激素的产生。
T76591	(Des-Glu5)-ACTH (1-24) (human, bovine, rat)
	(Des-Glu5)-ACTH (1-24) (human, bovine, rat) 是促肾上腺皮质激素 (ACTH) 的类似物。ACTH 是一种由垂体前叶腺产生的多肽激素，调节皮质醇和雄激素的产生。
T64249	CYP11B1-IN-2
	CYP11B1-IN-2 (compound 7aa) 是一种选择性的、口服具有活力的 CYP11B1 抑制剂，能够作用于 human CYP11B1 (IC50: 9 nM) 和 rat CYP11B1 (IC50: 25 nM)。CYP11B1-IN-2 能够用于研究皮质醇过量所致疾病。
T70763	KR-67607
	KR-67607, also known as NTX-101 is novel selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor. KR-67607 decreased 4-hydroxynonenal expression and increased antioxidant and mucus secretion in BAC-treated rat eyes. KR-67607 showed its protective effects against ischemia-reperfusion-induced eye injury. KR-67607 effectively reduced cortisol levels in mouse eyes and maintained the trabecular meshwork (TM) structure in the presence of transient ischemic stress. Furthermore, KR-67607 rever...
T35993	Epitalon (acetate)
	Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatoni...

化合物

Hydrocortisone 17-butyrate

Cat.No: T0270

Synonym: 丁酸氢化可的松,Cortisol 17-butyrate,Hydrocortisone butyrate

Target: Glucocorticoid Receptor, Annexin A, Adrenergic Receptor

Cortisol sulfate sodium

Cat.No: T75683

Cat.No: TP1031

Synonym: Tetracosactrin,替可克肽

Target: Others

Tetracosactide acetate

Cat.No: T35664

Target: Others

Cat.No: T21865

Target: PDE

18-Hydroxycortisol

Cat.No: T73794

5-alpha-Hydroxy-Laxogenin

Cat.No: T21253

Target: Others

ACTH 11-24 acetate(4237-93-8 free base)

Cat.No: TP1248L

Synonym: Adrenocorticotropic Hormone (11-24) acetate

Target: Melanocortin Receptor

Cat.No: T16510

Target: Dehydrogenase

ACTH 1-14 acetate(25696-21-3 free base)

Cat.No: TP1238L

Synonym: Adrenocorticotropic Hormone Fragment 1-14 acetate

Target: Adrenergic Receptor

ACTH (1-14) TFA (25696-21-3 free base)

Cat.No: TP1237

Synonym: Adrenocorticotropic Hormone Fragment 1-14 (TFA),ACTH (1-14) TFA

Cat.No: TP1238

Synonym: ACTH 1-14,Adrenocorticotropic Hormone Fragment 1-14

Cat.No: TP1248

Synonym: ACTH 11-24,Adrenocorticotropic Hormone (11-24)

Adrenocorticotropic hormone TFA

Cat.No: T73664

ACTH (11-24) (acetate)

Cat.No: T75979

Cat.No: T25443

Synonym: FW-34-569,FW34569,FW 34-569,FW-34569,FW34-569

ACTH (1-14) (TFA)

Cat.No: T75985

Adrenocorticotropic hormone

Cat.No: T73663

Hydrocortisone phosphate

Cat.No: T36927

Cat.No: T61593

(Des-His6)-ACTH (1-24) (human, bovine, rat)

Cat.No: T76595

(Des-Glu5)-ACTH (1-24) (human, bovine, rat)

Cat.No: T76591

Cat.No: T64249

Cat.No: T70763

Epitalon (acetate)

Cat.No: T35993

Cat. No.	Product Name	Target	Signaling Pathways
T1614	Hydrocortisone 氢化可的松,Cortisol	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Hydrocortisone (Cortisol) 是一种糖皮质激素，由肾上腺素皮质分泌。Hydrocortisone 激动糖皮质激素受体，可促进蛋白质分解代谢、糖异生、毛细血管壁稳定性、肾脏钙排泄，并抑制免疫和炎症反应。
T36472	Tetrahydro-11-deoxy Cortisol
	Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.
T1243	Hydrocortisone acetate Cortisol 21-acetate,Hydrocortisone 21-acetate,醋酸氢化可的松	Glucocorticoid Receptor; Annexin A; Endogenous Metabolite	Endocrinology/Hormones; GPCR/G Protein; Metabolism
	Hydrocortisone acetate (Cortisol 21-acetate) 是皮质类固醇，能够减少轻微皮肤刺激或痔疮引起的肿胀、搔痒和疼痛。
T75682	Cortisol sulfate
	Cortisol sulfate (Cortisol 21-sulfate) 是皮质醇的一种代谢物。Cortisol sulfate 是细胞内运皮质激素蛋白的一种特异性配体。
T13517	Allotetrahydrocortisol 5a-Tetrahydrocortisol	Others	Others
	Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human.
T17057	Tetrahydrocortisol	Others	Others
	The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase activity. Tetrahydrocortisol is cortisol metabolite.
T39991	18-Oxocortisol
	18-Oxocortisol is a cortisol derivative generated by aldosterone synthase (CYP11B2). It acts as a naturally occurring mineralocorticoid agonist and serves as a biomarker in adrenal vein sampling.
T36915	21-Deoxycortisol
	21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies. 1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive...
T9515	Dihydrocortisol

T2748	Cortodoxone 可托多松,11-Deoxycortisol,cortexolone,17α,21-dihydroxyprogesterone,Reichstein's substance S,11-Desoxycortisol	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Cortodoxone (11-Desoxycortisol) 是糖皮质类固醇激素，能够氧化为皮质醇。
T2884	Cortisone Kendall's compound E,17-Hydroxy-11-dehydrocorticosterone,可的松	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Cortisone (17-Hydroxy-11-dehydrocorticosterone) 是 Cortisol(一种糖皮质激素)的氧化代谢产物。Cortisone 具有消炎和免疫抑制的作用。Cortisone 在高浓度下对 Glucocorticoid 与Glucocorticoid-receptor 的结合具有部分干预作用。
T0034	Cortisone acetate 醋酸可的松,Cortisone 21-acetate,NSC 49420	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Cortisone acetate (NSC-49420) 是 Cortisol(一种糖皮质激素)的氧化代谢产物。它在高浓度下能够部分干预 Glucocorticoid 与Glucocorticoid-receptor 的结合。它具有免疫抑制和消炎的作用。

天然产物

Cat.No: T1614

Synonym: 氢化可的松,Cortisol

Target: Glucocorticoid Receptor, Endogenous Metabolite

Tetrahydro-11-deoxy Cortisol

Cat.No: T36472

Hydrocortisone acetate

Cat.No: T1243

Synonym: Cortisol 21-acetate,Hydrocortisone 21-acetate,醋酸氢化可的松

Target: Glucocorticoid Receptor, Annexin A, Endogenous Metabolite

Cortisol sulfate

Cat.No: T75682

Allotetrahydrocortisol

Cat.No: T13517

Synonym: 5a-Tetrahydrocortisol

Target: Others

Tetrahydrocortisol

Cat.No: T17057

Target: Others

Cat.No: T39991

21-Deoxycortisol

Cat.No: T36915

Dihydrocortisol

Cat.No: T9515

Cat.No: T2748

Synonym: 可托多松,11-Deoxycortisol,cortexolone,17α,21-dihydroxyprogesterone,Reichstein's substance S,11-Desoxycortisol

Target: Glucocorticoid Receptor, Endogenous Metabolite

Cat.No: T2884

Synonym: Kendall's compound E,17-Hydroxy-11-dehydrocorticosterone,可的松

Target: Glucocorticoid Receptor, Endogenous Metabolite

Cortisone acetate

Cat.No: T0034

Synonym: 醋酸可的松,Cortisone 21-acetate,NSC 49420

Target: Glucocorticoid Receptor, Endogenous Metabolite

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