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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T6804	Chetomin Chaetomin,NSC289491,BRN0077366	Apoptosis; HSP; HIF	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
	Chetomin (BRN0077366) 是球毛壳菌的活性成分，是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。
T78602	Chaetoglobosin C
	Chaetoglobosin C (Compound 4)，源自真菌Chaetomium globosum KMITL-N0802，为一种蒽醌-色酮类化合物，具备抗结核分枝杆菌的活性。
T30869	Chaetominine NSC 746369,NSC-746369,NSC746369
	Chaetominine is a type of cytotoxic alkaloid obtained from endophytic Chaetomium sp. IFB-E015.
T78588	Cochliodone A
	Cochliodone A 是一种从深海衍生真菌Chaetomium sp.培养物中分离的活性化合物，展示出了抗细菌和抗癌的特性。该化合物对多种细菌显示出有效的抑制作用，其最小抑菌浓度（MICs）分别为：V. vulnificus 15.3 μg/mL，V. rotiferianus 32.7 μg/mL，S. aureus ATCC 43300 15.9 μg/mL 和 S. aureus CGMCC 1.12409 16.3 μg/mL。Cochliodone A 同时对不同的癌细胞系也有抑制效果，其半数抑制浓度（IC50s）分别为：A549 28.1 μM，HeLa 20.7 μM，和 Hep G2 23.2 μM。
T35690	Myceliothermophin E
	Myceliothermophin E is a polyketide-amino acid hybrid fungal metabolite that has been found inT. thermophilusand has anticancer and antimicrobial activities.1,2It is cytotoxic to DLD-1, Hep3B, HepG2, and HGC-27 cancer cells (IC50s = 0.32, 0.42, 0.26, and 0.08 μg/ml, respectively).1Myceliothermophin E is active against methicillin-resistant, but not -sensitive,S. aureus(MICs = 15.8 and >100 μM, respectively).2 1.Gao, Y.-L., Zhang, M.-L., Wang, X., et al.Isolation and characterization of a new cyt...

化合物

Chetomin

Cat.No: T6804

Synonym: Chaetomin,NSC289491,BRN0077366

Target: Apoptosis, HSP, HIF

Synonym: NSC 746369,NSC-746369,NSC746369

Cat. No.	Product Name	Target	Signaling Pathways
TN6717	chaetoglobosin Vb	Others	Others
	chaetoglobosin Vb 是一种从内生球藻中分离出来的新型细胞松弛素生物碱。
T6803	Chaetocin 毛壳素	Histone Methyltransferase; Antibacterial; Antibiotic	Chromatin/Epigenetic; Microbiology/Virology
	Chaetocin 特异性抑制组蛋白甲基转移酶(HMT) SU(VAR)3-9，IC50值为0.6 μM。它还可抑制硫氧还蛋白还原酶，IC50值为4 μM。
T81179	Semicochliodinol Semicochliodinol A
	Semicochliodinol 是可以从属于毛壳真菌 (genus Chaetomium) 的水稻培养物中分离出的化合物。
T75453	11-epi-Chaetomugilin I
	11-epi-Chaetomugilin I 是一种在Chaetomium globosum 中发现的代谢物。11-epi-Chaetomugilin I 对小鼠 P388 白血病细胞系、人类 HL-60 白血病细胞系、小鼠 L1210 白血病细胞系和人类 KB 表皮样癌细胞系具有显著的细胞毒性活性。
T35609	19-O-Acetylchaetoglobosin A
	19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ...
T35752	Xanthoquinodin A1 Xanthoquinodin A1
	Xanthoquinodin A1 is a fungal metabolite that has been found inHumicolaand has diverse biological activities.1,2It inhibitsE. tenellaschizont formation in BHK-21 cells with a minimum effective concentration (MEC) value of 0.02 μg/ml.1Xanthoquinodin A1 is active againstB. subtilis,M. luteus,S. aureus,A. laidlawii, andB. fragilisin a disc assay when used at a concentration of 1 mg/ml. It is also active againstB. cereus(MIC = 0.44 μM).2Xanthoquinodin A1 is cytotoxic to KB, MCF-7, and NCI H187 cance...
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...