首页工具

登录

搜索结果

Search Results for " catechol o-methyltransferase "

16

抑制剂 & 化合物

1

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T75389	Catechol O-methyltransferase
	Catechol O-methyltransferase (COMT) 在镁的作用下，通过将 S-腺苷甲硫氨酸的甲基转移至多巴胺的羟基，生成3-甲氧基酪胺，从而参与调节大脑中肾上腺素、去甲肾上腺素和多巴胺的水平。存在于组织中的Catechol O-methyltransferase有两种形态：可溶性形式(S-COMT)和膜结合形式(MB-COMT)。
T24030	Entacapone acid AG1290,AG 1290,AG-1290,恩他卡朋酸	Transferase	Metabolism
	Entacapone acid (AG 1290) 是一种选择性和可逆的儿茶酚-O-甲基转移酶 (COMT) 抑制剂。
T16398	Opicapone BIA 9-1067	Transferase	Metabolism
	Opicapone (BIA 9-1067) 是第三代儿茶酚-O-甲基转移酶 (COMT)抑制剂，能够降低细胞 ATP 含量，IC50=98 μM。它有用于帕金森病和运动波动的研究潜力。
T2216	Entacapone OR-611,恩他卡朋	Transferase	Metabolism
	Entacapone (OR-611) 是可逆的、具有口服活性的、外周作用的儿茶酚-O-甲基转移酶抑制剂。它对大鼠脑、红细胞和肝脏 COMT 有抑制作用。它对 COMT 的选择性优于其他儿茶酚胺代谢酶。它抑制 FTO 去甲基化活性，可用于研究代谢紊乱。它可用于研究帕金森病。
T6708	Tolcapone Tasmar,Ro 40-7592,托卡朋	Apoptosis; Beta Amyloid; Transferase	Apoptosis; Metabolism; Neuroscience
	Tolcapone (Ro 40-7592) 是一种选择性，具有口服活性的外周和中枢COMT 抑制剂，在肝脏中对 COMT 的IC50为 773 nM。它还是一种 α-syn 和 Aβ42 寡聚和原纤维形成的有效抑制剂，可诱导氧化应激导致神经母细胞瘤细胞凋亡和抑制肿瘤生长。
T26797	BIA 3-335 BIA-3-335,BIA3335
	BIA 3-335, an inhibition of catechol-O-methyltransferase, could have applications for Parkinson's Disease.
T27162	DHMPA
	DHMPA is an inhibitor of catechol-O-methyltransferase (COMT), it also reduces tissue norepinephrine and blood pressure.
T28593	Ro 61-1448 Ro-61-1448,Ro 611448
	Ro 61-1448 is a metabolite of tolcapone, a catechol-O-methyltransferase inhibitor.
T29029	U-0521
	U-0521, an inhibitor of catechol-O-methyltransferase (COMT), enhances the availability and utilization of levodopa in the brain.
T36122	3-O-methyl-L-DOPA (hydrate)
	3-O-methyl-L-DOPA is a metabolite of L-DOPA , produced by the activity of catechol O-methyltransferase. 3-O-methyl-L-DOPA may have effects of its own or it may compete with the actions of L-DOPA.
T16279	Nebicapone BIA 3-202	Others	Others
	Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of CO
T70608	cis-Entacapone
	cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone. It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure.
T11207	Entacapone sodium salt	Others	Others
	Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells.Entacapone sodium salt is a specific, potent, peripherally acting catech...
T26997	CGP-28014
	CGP-28014 is an inhibitor of catechol-O-methyltransferase. CGP-28014 increases the renal excretion of both dopamine and dihydroxyphenylacetic acid (DOPAC) but does not affect renal sodium handling indicating a different mechanism of action. CGP-28014 sign
T36207	Methylspinazarin
	Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg. \|1. Chimura, H., Sawa, T., Takita, T., et al. Methylspinazarin and dihydromethylspinazarin, gate...
TMIH-0576	Tolcapone-d7
	Tolcapone-d7 是 Tolcapone 的氘代化合物。Tolcapone 的 CAS 号为 134308-13-7。Tolcapone是一种选择性，具有口服活性的外周和中枢COMT抑制剂，在肝脏中对 COMT 的IC50为 773 nM。它还是一种 α-syn 和 Aβ42 寡聚和原纤维形成的有效抑制剂，可诱导氧化应激导致神经母细胞瘤细胞凋亡和抑制肿瘤生长。

化合物

Catechol O-methyltransferase

Cat.No: T75389

Entacapone acid

Cat.No: T24030

Synonym: AG1290,AG 1290,AG-1290,恩他卡朋酸

Target: Transferase

Cat.No: T16398

Synonym: BIA 9-1067

Target: Transferase

Cat.No: T2216

Synonym: OR-611,恩他卡朋

Target: Transferase

Cat.No: T6708

Synonym: Tasmar,Ro 40-7592,托卡朋

Target: Apoptosis, Beta Amyloid, Transferase

Cat.No: T26797

Synonym: BIA-3-335,BIA3335

Cat.No: T27162

Cat.No: T28593

Synonym: Ro-61-1448,Ro 611448

Cat.No: T29029

3-O-methyl-L-DOPA (hydrate)

Cat.No: T36122

Cat.No: T16279

Synonym: BIA 3-202

Target: Others

Cat.No: T70608

Entacapone sodium salt

Cat.No: T11207

Target: Others

Cat.No: T26997

Methylspinazarin

Cat.No: T36207

Cat.No: TMIH-0576

Cat. No.	Product Name	Target	Signaling Pathways
T2209	Serotonin hydrochloride 5-HT hydrochloride,5-羟基色胺盐酸盐,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride	5-HT Receptor; Endogenous Metabolite; Transferase	GPCR/G Protein; Metabolism; Neuroscience
	Serotonin hydrochloride (Serotonin HCl) 是一种内源性 5-HT 受体激动剂、CNS 中的单胺神经递质和儿茶酚 O-甲基转移酶 (COMT) 抑制剂，Ki 值为 44 μM。

天然产物

Serotonin hydrochloride

Cat.No: T2209

Synonym: 5-HT hydrochloride,5-羟基色胺盐酸盐,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride

Target: 5-HT Receptor, Endogenous Metabolite, Transferase

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼