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Cat. No. | Product Name | Target | Signaling Pathways |
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T1058 |
Carboplatin
NSC 241240,卡铂,CBDCA,JM-8 |
DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Carboplatin (JM-8) 是一种顺铂衍生物,一种 DNA 合成抑制剂。Carboplatin 能够与 DNA 结合,抑制复制和转录并诱导细胞死亡。Carboplatin 具有抗肿瘤活性。 | |||
T68065 |
Enloplatin
|
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Enloplatin 是一种卡铂类似物,在治疗晚期卵巢癌有部分作用。 | |||
T77401 |
Bavituximab
Anti-PS MAb 3G4 |
Others | Others |
Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) 是一种针对磷脂酰丝氨酸 (PS) 的单克隆抗体,具有血管靶向和免疫调节特性,能够重新激活抗肿瘤免疫来抑制肿瘤生长。Bavituximab 具有抗癌活性,常联合Paclitaxel 和 Carboplatin 来研究非小细胞肺癌。 | |||
T27307L |
Fasnall HCl
Fasnall HCl(929978-58-5 Free base) |
Fatty Acid Synthase | Metabolism |
Fasnall HCl 是一种FASN 选择性抑制剂,通过其辅助因子结合位点起作用。Fasnall HCl 在HER2(+)乳腺癌MMTV-Neu 模型中也显示出强大的抗肿瘤活性,特别是与卡铂联合使用时。 | |||
T9864 |
Debio-0123
WEE1-IN-5 |
Wee1 | Cell Cycle/Checkpoint |
Debio-0123 (WEE1-IN-5) 是一种口服有效且高度特异性的WEE1抑制剂,IC50值在低纳摩尔范围内。Debio-0123 抑制磷酸化 CDC2。Debio-0123 可增强卡铂在体内的抗肿瘤活性,而这两种药物单独使用都没有活性。 | |||
T27307 |
Fasnall
|
Fatty Acid Synthase | Metabolism |
Fasnall 是一种选择性 FASN 抑制剂,通过其辅因子结合位点起作用。 Fasnall 在 HER2(+) 乳腺癌的 MMTV-Neu 模型中显示出有效的抗肿瘤活性,尤其是与卡铂联合使用时。 | |||
T38765 |
UBE2T/FANCL-IN-1
UBE2T/FANCL-IN-1 |
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UBE2T/FANCL-IN-1 is a highly effective inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation. It greatly enhances the sensitivity of cells to Carboplatin, a DNA cross-linking agent. | |||
T27790 |
Labradimil
RMP-7,ALK-01-040,Receptor-mediated permeabiliser-7,DRG0182,DRG 0182,DRG-0182 |
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Labradimil is a bradykinin B2 receptor agonist. Labradimil increases the permeability of human brain microvascular endothelial cell monolayers. Labradimil enhances delivery of hydrophilic chemotherapeutics and increases survival in rats with metastatic tu | |||
T28398 |
Phenanthriplatin
cis-[Pt(NH3)2-(phenanthridine)Cl]NO3 |
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Phenanthriplatin, also known as cis-[Pt(NH3)2-(phenanthridine)Cl]NO3, is a new drug candidate. It belongs to a family of platinum(II)-based agents which includes cisplatin, oxaliplatin and carboplatin. Phenanthriplatin Acts As a Covalent Poison of Topoiso |
Cat. No. | Product Name | Target | Signaling Pathways |
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T36893 |
4-oxo Withaferin A
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4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.References1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian ca... | |||
T35647 |
4-oxo-27-TBDMS Withaferin A
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4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.References1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of wi... |