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Search Results for " camptothecin "

40

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T24610	Pegamotecan Prothecan,PEG-camptothecin,PEG-beta-CPT	Topoisomerase	DNA Damage/DNA Repair
	Pegamotecan (PEG-camptothecin)是一种拓扑异构酶I(TOP1)抑制剂，具有抗癌活性，它可用于治疗食管癌、非小细胞肺癌和胰腺癌。
T77701	FL118 FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin	Survivin	Apoptosis
	FL118是一种新型存活素抑制剂，可抑制癌症干细胞样特性。FL118 是一种新型喜树碱类似物，具有抗癌活性，通过 Wnt/β-catenin 信号通路抑制上皮-间充质转化，从而抑制人乳腺癌细胞的迁移和侵袭。
T40049	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin
	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), is a camptothecin payload which can be utilized in the synthesis of a camptothecin antibody-drug conjugate (ADC) by conjugation to a monoclonal antibody (mAb).
T27113	Camptothecin-20(S)-O-propionate CZ 48,CZ48,CZ-48
	CZ-48 is a DNA topoisomerase inhibitor.
T83468	10NH2-11F-Camptothecin
	10NH2-11F-Camptothecin 是抗癌活性的抗体-活性分子偶联物(ADC)，用于癌症疾病的研究。
T83244	7Ethanol-10NH2-11F-Camptothecin
	7Ethanol-10NH2-11F-Camptothecin 是一抗体-活性分子偶联物(ADC)，具有抑制肿瘤生长的功能，适用于癌症研究。
T75134	MC-GGFG-AM-(10Me-11F-Camptothecin)
	MC-GGFG-AM-(10Me-11F-Camptothecin) 是ZW251合成的Linker-Payload偶联物。ZW251是靶向人GPC3的抗体-活性分子偶联物(ADC)，包括人源化IgG1抗体、喜树碱(camptothecin)类的扑异构酶1抑制剂ZD06519及连接子（马来酰亚胺锚定和甘酰甘酰苯丙酰甘氨酸(GGFG)-氨基甲基(AM)可切割连接体）。该药物对人和食蟹猴GPC3具高亲和力，在表达GPC3的HCC细胞系中快速内化并可对GPC3阴性癌细胞进行旁观者介导杀伤。
T81834	MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)
	MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) (compound 141) 为ADC用途的drug-linker conjugate，其结构包括7ethanol-10NH2-11F-Camptothecin 与蛋白酶可降解(cleavable)的MC-GGFG通过化学键连接形成。
T79883	9-Chloromethyl-10-hydroxy-11-F-Camptothecin	Topoisomerase	DNA Damage/DNA Repair
	9-Chloromethyl-10-Hydroxy-11-F-Camptothecin是一款喜树碱类衍生化合物，具有DNA拓扑异构酶I (Topo I)抑制活性，应用于癌症治疗的研究领域。
T77820	7-Aminomethyl-10-methyl-11-fluoro camptothecin
	7-Aminomethyl-10-methyl-11-fluoro camptothecin为MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin的毒素分子，适用于喜树碱ADC的制备。
T81833	MC-GGFG-AM-(10NH2-11F-Camptothecin)
	MC-GGFG-AM-(10NH2-11F-Camptothecin) 是一种ADC，其通过pH敏感的可水解连接物与Trop-2针对性抗体sacituzumab偶联，展现出针对癌症的活性，适用于癌症研究领域。
T71135	Calphostin I
	The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides. The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity.
T71137	Simmitecan hydrochloride	Topoisomerase	DNA Damage/DNA Repair
	Simmitecan hydrochloride 是一种喜树碱衍生物，是一种拓扑异构酶 I 抑制剂，具有抗癌活性，可用于研究是实体瘤。
T7551	Belotecan hydrochloride CKD-602	Topoisomerase	DNA Damage/DNA Repair
	Belotecan hydrochloride (CKD-602) 是一种合成的水溶性喜树碱衍生物和拓扑异构酶 I 抑制剂，具有潜在的抗肿瘤活性。
T60163	Lurtotecan GI147211,OSI-211	Topoisomerase	DNA Damage/DNA Repair
	Lurtotecan (GI147211) 是一种半合成的喜树碱类似物。Lurtotecan 是一种具有抗癌作用的拓扑异构酶I 抑制剂。
T7187	Genz-644282 Genz644282	Topoisomerase	DNA Damage/DNA Repair
	Genz-644282 是一种用于癌症治疗的新型非喜树碱拓扑异构酶 I 抑制剂。
T21319	Gimatecan LBQ707,STI481	Topoisomerase	DNA Damage/DNA Repair
	Gimatecan (STI481) 是一种有效的拓扑异构酶 I (topoisomerase I) 抑制剂。Gimatecan 是一种具有口服活性的喜树碱类似物。具有抗肿瘤活性。
T21319L	Gimatecan HCl ST1481 HCL,Gimatecan HCl(292618-32-7 Free base)	Topoisomerase	DNA Damage/DNA Repair
	Gimatecan HCl (ST1481 HCL) 是一种有效的拓扑异构酶 I (topoisomerase I) 抑制剂。Gimatecan HCl 是一种具有口服活性的喜树碱类似物。具有抗肿瘤活性。
T14340	Atiratecan TP300	Others	Others
	Atiratecan (TP300) is a prodrug of camptothecin analog CH0793076. Atiratecan shows antitumor activity against both breast cancer resistance protein (BCRP)-positive and -negative xenografts in mouse xenograft models[1]. Atiratecan does not inhibit acetylch
T30522	BMS-422461 BMS422461,BMS 422461
	BMS-422461 is a prodrug of the novel fluoro-substituted camptothecin analog, BMS-286309.
T40879	7-MAD-MDCPT
	7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).
T69862	Afeletecan HCl
	Afeletecan, also known as BAY 56-3722, is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA repli...
T70380	ZBH-1205
	ZBH-1205 is a novel camptothecin derivative, revealing potent antitumor activities mainly through cell apoptosis pathway, being more effective than cpt-11 and sn38 at inhibiting topoismerase-1
T74494	Antitumor agent-63
	Antitumor agent-63（Compound 40），一种20 (S)-O-linked camptothecin (CPT) 糖复合物，作为抗肿瘤剂，对正常细胞展现出无毒性。该化合物表现出高稳定性和低topoisomeraseI (Topo I)直接抑制活性。
T73534	T01-1
	T01-1 是一种抗癌剂 (喜树碱衍生物)，具有较好的抗肿瘤细胞增殖活性。
T72756	Gly-7-MAD-MDCPT
	Gly-7-MAD-MDCPT 是一种抗癌剂。Gly-7-MAD-MDCPT 是一种喜树碱 (Camptothecin) 化合物，对多种癌细胞有细胞毒性，IC50为 10-1000 nM。
T39941	MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT
	MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a Camptothecin-linker. MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a drug-linker conjugate for antibody-drug conjugate (ADC).
T14454	Azido-PEG5-acid	Others	Others
	Azido-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as the conjugate CPT-APO (CPT: Camptothecin.
T39681	Elomotecan hydrochloride BN 80927
	Elomotecan hydrochloride (BN 80927), a camptothecin analog from the homocamptothecin family (hCPT), is a highly potent inhibitor of both topoisomerases I and II. It demonstrates superior efficacy in reducing the proliferation of various tumor cells compared to other reference anticancer drugs targeting these topoisomerases.
T28648	S39625 S-39625,S 39625
	S39625, an E-ring camptothecin keto analogue, is a stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chem
T62435	Belotecan
	Belotecan (CKD-602 free base) 是一种 DNA topoisomerase I 抑制剂。Belotecan 能够阻滞细胞周期，并诱导细胞凋亡。Belotecan 是一种具有抗肿瘤作用的喜树碱衍生物，能够用于研究癌症。
T62225	Topoisomerase I inhibitor 8
	Topoisomerase I inhibitor 8 是一种喜树碱六环类似物，也是 topoisomerase I 的强效抑制剂，对肿瘤细胞有毒性。
T77816	Deruxtecan analog 2
	Deruxtecananalog 2（示例9 P3）是一种含活性分子-linker的Deruxtecan类似物，由Camptothecin（一种对多种癌症如结直肠癌、乳腺癌、肺癌和卵巢癌具有抗肿瘤活性的Topo I抑制剂）和linker组成，主要用于开发针对EGFR2的抗体药物偶联物（ADC）活性分子。
T23654	Afeletecan free base BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan
	Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps are inhibited and subsequent collis
T14945	CH-0793076 TP3076	Topoisomerase	DNA Damage/DNA Repair
	CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisomerase I (IC50: 2.3 μM).
T68062	Elomotecan BN 80927 free base
	Elomotecan (BN 80927 free base) 是一种有效的拓扑异构酶 I (topoisomerases I) 和 II 抑制剂。Elomotecan 是属于高喜树碱家族 (hCPT) 的喜树碱类似物。与其他拓扑异构酶 I 和 II 的参考抗癌药物相比，Elomotecan 减少不同肿瘤细胞的增殖效果更好。
T73672	CH-0793076 TFA
	CH-0793076 (TP3076) TFA，喜树碱的六环类似物，是 TP300 的活性药物和主要代谢物。CH-0793076 TFA 抑制 DNA 拓扑异构酶 I (DNAtopoisomeraseI)，IC50为 2.3 μM。CH-0793076 TFA 对表达 BCRP(乳腺癌耐药蛋白) 的细胞也有活性。
T73422	CPT-Se4	Topoisomerase	DNA Damage/DNA Repair
	CPT-Se4为含硒前体活性分子的喜树碱(CPT)衍生物，对癌细胞具有较高杀伤力和抑制肿瘤生长效果。在降低GSH/GSSG比率和总硫醇的同时，CPT-Se4能够增加Hep G2细胞中的ROS水平，触发癌细胞凋亡。此化合物对HeLa、Hep G2、A549和SMMC-7721细胞系显示出显著的细胞毒性，IC50值范围为2.54-6.4 μM。
T73421	CPT-Se3	Topoisomerase	DNA Damage/DNA Repair
	CPT-Se3为含硒的喜树碱前体活性分子，其杀癌和抗肿瘤效力显著。它通过降低GSH/GSSG比率及总硫醇水平，增加Hep G2细胞中ROS含量，触发癌细胞凋亡。CPT-Se3对HeLa、Hep G2、A549及SMMC-7721细胞线具备显着细胞毒性，IC50值介于2.19-4.7 μM。
T83854	BRC4wt TFA
	BRC4wt是一种从人类BRCA2的BRC4重复区(1521-1536)衍生而来的乙酰化肽，并且是BRCA2与RAD51之间的蛋白质-蛋白质相互作用的抑制剂。当与阳离子穿膜肽(Arg)9结合时，BRC4wt缩短了体外DNA复制轨迹长度，并降低了由DNA拓扑异构酶I抑制剂坎普特西汀引起的DNA损伤的同源修复频率，同时也增强了聚(ADP-核糖)聚合酶(PARP)抑制剂奥拉帕尼在HeLa人类宫颈癌细胞和U2OS人类骨肉瘤细胞中诱导的细胞死亡，但在非癌症细胞hTERT RPE-1、MRC-5或MCF-10A中则不然。

化合物

Cat.No: T24610

Synonym: Prothecan,PEG-camptothecin,PEG-beta-CPT

Target: Topoisomerase

Cat.No: T77701

Synonym: FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin

Target: Survivin

MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin

Cat.No: T40049

Synonym: MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin

Camptothecin-20(S)-O-propionate

Cat.No: T27113

Synonym: CZ 48,CZ48,CZ-48

10NH2-11F-Camptothecin

Cat.No: T83468

7Ethanol-10NH2-11F-Camptothecin

Cat.No: T83244

MC-GGFG-AM-(10Me-11F-Camptothecin)

Cat.No: T75134

MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)

Cat.No: T81834

9-Chloromethyl-10-hydroxy-11-F-Camptothecin

Cat.No: T79883

Target: Topoisomerase

7-Aminomethyl-10-methyl-11-fluoro camptothecin

Cat.No: T77820

MC-GGFG-AM-(10NH2-11F-Camptothecin)

Cat.No: T81833

Cat.No: T71135

Simmitecan hydrochloride

Cat.No: T71137

Target: Topoisomerase

Belotecan hydrochloride

Cat.No: T7551

Synonym: CKD-602

Target: Topoisomerase

Cat.No: T60163

Synonym: GI147211,OSI-211

Target: Topoisomerase

Cat.No: T7187

Synonym: Genz644282

Target: Topoisomerase

Cat.No: T21319

Synonym: LBQ707,STI481

Target: Topoisomerase

Cat.No: T21319L

Synonym: ST1481 HCL,Gimatecan HCl(292618-32-7 Free base)

Target: Topoisomerase

Cat.No: T14340

Synonym: TP300

Target: Others

Cat.No: T30522

Synonym: BMS422461,BMS 422461

Cat.No: T40879

Cat.No: T69862

Cat.No: T70380

Antitumor agent-63

Cat.No: T74494

Cat.No: T73534

Gly-7-MAD-MDCPT

Cat.No: T72756

MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT

Cat.No: T39941

Synonym: MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT

Azido-PEG5-acid

Cat.No: T14454

Target: Others

Elomotecan hydrochloride

Cat.No: T39681

Synonym: BN 80927

Cat.No: T28648

Synonym: S-39625,S 39625

Cat.No: T62435

Topoisomerase I inhibitor 8

Cat.No: T62225

Deruxtecan analog 2

Cat.No: T77816

Afeletecan free base

Cat.No: T23654

Synonym: BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan

Cat.No: T14945

Synonym: TP3076

Target: Topoisomerase

Cat.No: T68062

Synonym: BN 80927 free base

Cat.No: T73672

Cat.No: T73422

Target: Topoisomerase

Cat.No: T73421

Target: Topoisomerase

Cat.No: T83854

Cat. No.	Product Name	Target	Signaling Pathways
T1123	Camptothecin NSC-100880,Campathecin,喜树碱,(S)-(+)-Camptothecin,CPT	Apoptosis; Influenza Virus; Topoisomerase; Antibiotic; Antifungal	Apoptosis; DNA Damage/DNA Repair; Microbiology/Virology
	Camptothecin (CPT) 属于生物碱类天然产物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂 (IC50=679 nM)，具有特异性。Camptothecin 具有抗肿瘤活性，可以诱导细胞凋亡。
T40179	Sodium Camptothecin	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Sodium Camptothecin 是一种植物生物碱，具有抗肿瘤活性。它是可逆 RNA 合成抑制剂，可以抑制腺病毒的复制。它能抑制 DNA 合成，并引起细胞内预形成的病毒 DNA 断裂。
TN1176	10-Nitro-camptothecin 9-硝基喜树碱	Others	Others
	10-Nitro-camptothecin is a natural product
T3S1957	9-amino-CPT 9-氨基喜树碱,Aminocamptothecin,9-amino-2(S)-camptothecin,9-Aminocamptothecin	Topoisomerase	DNA Damage/DNA Repair
	9-amino-CPT (Aminocamptothecin) 是一种拓扑异构酶I 的抑制剂，具有抗肿瘤活性。
T0486L	Irinotecan Hydrochloride 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan Hydrochloride (CPT-11 hydrochloride) 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。
TN2460	12-Ethyl-9-hydroxycamptothecin 7-乙基-10-羟基喜树碱,7-Ethyl-10-Hydroxy-Camptothecin	Others	Others
	12-Ethyl-9-hydroxycamptothecin 是一种 Camptothecin 的衍生物。其中Camptothecin (CPT) 是一种生物碱，也是 DNA 拓扑异构酶I 抑制剂(IC50:679 nM)。
T4S1951	10-Methoxycamptothecin	Others	Others
	10-Methoxycamptothecin 是分离自喜树的喜树碱衍生物，具有高抗癌特性。通过对 2774 细胞系的抗肿瘤活性测定，发现它比 10-羟基喜树碱的细胞毒性更高。
T3S1955	7-Ethylcamptothecin	Others	Others
	7-Ethylcamptothecin 是一种喜树碱类似物。其中喜树碱是一种细胞毒性生物碱，从喜树中分离出得到，对 L1210 白血病和 Walker 256 癌肉瘤模型具有很强的抗肿瘤活性。
T5S1952	9-Methoxycamptothecin	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	9-Methoxycamptothecin 是从臭味假柴龙树中分离得到的一种天然产物，通过抑制拓扑异构酶起到抗肿瘤作用，具有强效的诱导 G2/M 期细胞和癌细胞凋亡的作用。
T2764	(S)-10-Hydroxycamptothecin 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡，可研究肝癌、胃癌、结肠癌和白血病。
T4952	9-Hydroxycamptothecin 9-HCPT,9-羟基喜树碱,10-Hydroxycampothecin	Topoisomerase	DNA Damage/DNA Repair
	9-Hydroxycampothecin 是具有抗癌活性的喜树碱衍生物。
T1521	(±)-10-Hydroxycamptothecin Hydroxy Camptothecine,10-羟基喜树碱,10-Hydroxycamptothecin	Topoisomerase	DNA Damage/DNA Repair
	(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) 是一种从喜树茎木中分离出来的生物碱，抑制拓扑异构酶 I 活性，具有广谱抗肿瘤活性。
T6228	Irinotecan CPT-11,Topotecin,伊立替康,(+)-Irinotecan	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan (CPT-11) 是喜树碱的衍生物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂。Irinotecan 通过与 Topo I 复合物结合来阻止 DNA 链的重新连接，并导致双链 DNA 断裂和细胞死亡，具有抗肿瘤活性。
T5853	Rubitecan RFS 2000,鲁比特康,9-Nitrocamptothecin	Topoisomerase	DNA Damage/DNA Repair
	Rubitecan (9-Nitrocamptothecin) 是一种与喜树碱相关的半合成药物，具有有效的抗肿瘤和抗病毒特性。它是一种 DNA 拓扑异构酶 I 抑制剂，以浓度依赖性方式抑制 DNA 拓扑异构酶 I 并在无细胞试验中增加超螺旋 DNA 的比例。

天然产物

Cat.No: T1123

Synonym: NSC-100880,Campathecin,喜树碱,(S)-(+)-Camptothecin,CPT

Target: Apoptosis, Influenza Virus, Topoisomerase, Antibiotic, Antifungal

Sodium Camptothecin

Cat.No: T40179

Target: DNA/RNA Synthesis

10-Nitro-camptothecin

Cat.No: TN1176

Synonym: 9-硝基喜树碱

Target: Others

Cat.No: T3S1957

Synonym: 9-氨基喜树碱,Aminocamptothecin,9-amino-2(S)-camptothecin,9-Aminocamptothecin

Target: Topoisomerase

Irinotecan Hydrochloride

Cat.No: T0486L

Synonym: 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride

Target: Topoisomerase, Autophagy

12-Ethyl-9-hydroxycamptothecin

Cat.No: TN2460

Synonym: 7-乙基-10-羟基喜树碱,7-Ethyl-10-Hydroxy-Camptothecin

Target: Others

10-Methoxycamptothecin

Cat.No: T4S1951

Target: Others

7-Ethylcamptothecin

Cat.No: T3S1955

Target: Others

9-Methoxycamptothecin

Cat.No: T5S1952

Target: Apoptosis, Topoisomerase

(S)-10-Hydroxycamptothecin

Cat.No: T2764

Synonym: 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT

Target: Apoptosis, Topoisomerase

9-Hydroxycamptothecin

Cat.No: T4952

Synonym: 9-HCPT,9-羟基喜树碱,10-Hydroxycampothecin

Target: Topoisomerase

(±)-10-Hydroxycamptothecin

Cat.No: T1521

Synonym: Hydroxy Camptothecine,10-羟基喜树碱,10-Hydroxycamptothecin

Target: Topoisomerase

Cat.No: T6228

Synonym: CPT-11,Topotecin,伊立替康,(+)-Irinotecan

Target: Topoisomerase, Autophagy

Cat.No: T5853

Synonym: RFS 2000,鲁比特康,9-Nitrocamptothecin

Target: Topoisomerase

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