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35

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T78377	CTP
	CTP为一种具心脏靶向性的肽。它在体外能够转导心肌细胞，并能有效特异性地转导小鼠心脏组织。CTP可专门用于将治疗性肽、蛋白质及核酸传递至心脏。
T7881	CTP disodium dihydrate	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	CTP disodium dihydrate 是 P2X4 嘌呤受体的激动剂。
T31108	CTP-347 CTP347,CTP 347
	CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.
T72505	CTP Synthetase-IN-1	Others	Others
	CTP Synthetase-IN-1 是一种具有口服活性和高效性的胞苷 5'-三磷酸合成酶 (CTPS) 抑制剂，具有潜在的抗肿瘤活性，在炎症动物模型中显示出抗炎活性，抑制人 CTPS1 和人 CTPS2，可用于研究关节炎和类风湿性关节炎。
T31109	CTP-499
	CTP499, a selective PDE inhibitor, and the deuterium-containing agent is an HDX analogue and a metabolite of hexantheobromine that slows the progression of type 2 diabetic nephropathy in patients with macroalbuminuria.
T61297	CTP inhibitor
	CTP inhibitor is a highly effective and specific inhibitor of the plasma membrane citrate transporter (PMCT), effectively targeting and inhibiting the transporter responsible for citrate transport. [1]
T82665	CTP-NBD	NF-κB	NF-κB
	CTP-NBD (CTP-NBD) 是一种具有细胞渗透性的特异性 NFκB (NFκB) 抑制剂，常用于结肠炎研究。
T27097	CTP518 CTP 518,Deuterated Atazanivir-D3-1,CTP-518
	CTP518, a deuterated Atazanivir derivative, is a HIV protease inhibitor.
T27098	Ivacaftor-D9 deutivacaftor,CTP-656
	CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.
T38718	Cytarabine triphosphate Cytarabine triphosphate,Ara-CTP
	Cytarabine triphosphate (Ara-CTP), a competitive inhibitor of DNA synthesis and an active metabolite of Cytarabine, exhibits predictive potential for leukemic blasts' chemosensitivity to Cytarabine through intracellular levels.
T40753	Cytidine-5'-triphosphate Cytidine triphosphate,Cytidine-5'-triphosphate,5'-CTP
	Cytidine 5'-triphosphate (5'-CTP), also known as cytidine triphosphate, is a nucleoside triphosphate that plays a crucial role as a building block for nucleotides and nucleic acids, as well as lipid biosynthesis. It is synthesized through the catalytic action of cytidine triphosphate synthase, which converts uridine 5'-triphosphate (UTP) to cytidine 5'-triphosphate. Cytidine 5'-triphosphate is an essential biomolecule in T. gondii's de novo pyrimidine biosynthetic pathway.
T22301	L-838417 D9 CTP354,CTP354 (C-21191),C-21191	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	L-838417 D9 (C-21191) 是 L-838417 的氘代物。其中L-838417 是亚型选择性GABAA 正变构调节剂，在 α2, α3 和 α5 亚型中作为部分激动剂。
T15014	CTPB	Histone Acetyltransferase	Chromatin/Epigenetic
	CTPB 是一种有效的 p300 组蛋白乙酰转移酶 (HAT) 活化剂，可用于制备毛发生长促进剂和/或脱发治疗剂。
T8732	CTPI-2	Others; Mitochondrial Metabolism	Metabolism; Others
	CTPI-2 是一种特异性线粒体柠檬酸盐载体SLC25A1抑制剂，KD=3.5 μM，具有抗肿瘤作用。它能够抑制糖酵解、PPARγ 及其下游靶点葡萄糖转运蛋白 GLUT4。它阻断非酒精性脂肪性肝炎逆转脂肪变性的显著改变，防止演变为脂肪性肝炎，减少肝脏和脂肪组织中炎性巨噬细胞的浸润，并显著减轻由高脂肪饮食引起的肥胖。
T40771	5-Propargylamino-3'-azidomethyl-dCTP
	5-Propargylamino-3'-azidomethyl-dCTP, is a nucleoside molecule. It finds utility in DNA synthesis and DNA sequencing.
T38546	5-Propargylamino-dCTP
	5-Propargylamino-dCTP, also known as dCTP-PA, is a nucleoside molecule. It can form conjugates with molecular markers, enabling its application in nucleic acid labeling and sequence analysis.
T23778	BCTP
	BCTP is a polymodal inhibitor of TRPV1. It has a reduced liability for hyperthermia.
T38526	5-Propargylamino-ddCTP
	5-Propargylamino-ddCTP is a nucleoside molecule utilized in the synthesis of cyanine dye-nucleotide conjugate, which finds application in nucleic acid labeling and sequence analysis.
T63602	ddCTP trisodium
	ddCTP trisodium 是一种核苷类似物，靶向人类免疫缺陷病毒 (HIV) 的逆转录酶，可用于研究艾滋病 (AIDS)。ddCTP trisodium 是一类双脱氧核糖核苷酸 (ddNTPs)，也是一种 DNA 聚合酶链延长抑制剂，能够用于 DNA 测序的研究。
T75376	Biotin-11-dCTP
	Biotin-11-dCTP 是一种用于 DNA 标记的荧光染料。
T70387	CCCTP
	CCCTP is a potent inhibitor of the 11β-HSD-1 enzyme with reduced pregnane-X receptor (PXR) transactivation activity.
T40759	ddCTP
	ddCTP is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing.
T75387	Cy3-dCTP
	Cy3-dCTP为直接标记DNA探针的荧光标记核苷酸，同时作为氰染料标记的三磷酸核苷酸，适用于成像研究。
T74365	Chol-CTPP
	Chol-CTPP是针对血脑屏障(BBB)与胶质瘤(glioma)细胞展现双重靶向性的配体，可以与Chol-TPP合成为Lip-CTPP。Lip-CTPP作为一种潜在载体，可用于联合阿霉素(DOX)和氯胺达明(LND)发挥抗胶质瘤(anti-glioma)效果。此载体能够增强对肿瘤细胞的增殖、迁移及侵袭抑制，同时促进细胞凋亡(apoptosis)与坏死(necrosis)，并干扰线粒体功能。
T31163	Cytidine 5'-diphosphate disodium CDP sodium salt,Cytidine 5'-diphosphate disodium salt,胞苷-5'-二磷酸二钠盐,Cytidine diphosphate sodium salt	Others	Others
	Cytidine 5'-diphosphate disodium (CDP sodium salt) 产生 CTP 以支持 DNA 和 RNA 生物合成和核糖核苷酸还原酶以产生 dCMP。
T0033	Miltefosine HePC,米替福新,Hexadecyl phosphocholine	Akt; HIV Protease; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Miltefosine (HePC) 是一种广谱抗微生物剂，是治疗内脏和皮肤利什曼病的药物。它是 CTP 磷酸胆碱胞苷基转移酶的抑制剂。
T83295	5-Azacytidine 5′-triphosphate sodium
	5-Azacytidine 5’-triphosphate sodium 为胞苷类似物，能在DNA依赖性RNA聚合酶反应中抑制[3H]CTP掺入，而不影响[3H]UTP的掺入。
T74145	Deutarserine
	Deutarserine 是内源性 D-丝氨酸 (CTP 692) 的氘代物，用于成人精神分裂症的研究。
T10677	Carbodine	Others	Others
	Carbodine (Carbocyclic cytidine) is a broad-spectrum antiviral agent and targets CTP synthetase that converts UTP to CTP. It possesses significant antiviral activity against influenza virus types A0/PR-8/34 and A2/Aichi/2/68 in vitro.
T83296	5-Azacytidine 5′-triphosphate
	5-Azacytidine 5′-triphosphate (5-aza-CMP) 为一种胞苷类似物，可抑制 DNA 依赖性 RNA 聚合酶反响中的 [3H]CTP 并入 RNA，而不影响 [3H]UTP 的并入。
T74584	5-Methylcytidine 5′-triphosphate
	5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) 为修饰核苷三磷酸，用以替代未修饰 mRNA，以增强翻译性能与稳定性，显著降低人类及其他哺乳动物细胞的先天免疫反应。
T74585	5-Methylcytidine 5′-triphosphate trisodium
	5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) trisodium 为一种修饰核苷三磷酸，可用以替换原生mRNA，进而提升翻译效率与稳定性，同时在人类及其他哺乳动物细胞中显著降低先天免疫反应。
T35460	β-Endorphin (rat)
	β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities. It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites of action which include plasma, gut, skin, placenta, cerebrospinal fluid, and cardiac tissues. β-EP induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens that can be reversed by the μ-opioid antagonist CTP and δ-opioid antagon...
T35416	α-D-Glucose-1-phosphate (sodium salt hydrate)
	α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen breakdownviaphosphorolytic cleavage of glycogen by glycogen phosphorylase.1It can be converted to glucose-6-phosphate by phosphoglucomutase. α-D-Glucose-1-phosphate is combined with CTP by α-D-glucose-1-phosphate cytidylyltransferase to form CDP-glucose in the first step of CDP-...
T36881	NHC-diphosphate triammonium
	NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2]. In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono...

化合物

Cat.No: T78377

CTP disodium dihydrate

Cat.No: T7881

Target: P2X Receptor

Cat.No: T31108

Synonym: CTP347,CTP 347

CTP Synthetase-IN-1

Cat.No: T72505

Target: Others

Cat.No: T31109

CTP inhibitor

Cat.No: T61297

Cat.No: T82665

Target: NF-κB

Cat.No: T27097

Synonym: CTP 518,Deuterated Atazanivir-D3-1,CTP-518

Cat.No: T27098

Synonym: deutivacaftor,CTP-656

Cytarabine triphosphate

Cat.No: T38718

Synonym: Cytarabine triphosphate,Ara-CTP

Cytidine-5'-triphosphate

Cat.No: T40753

Synonym: Cytidine triphosphate,Cytidine-5'-triphosphate,5'-CTP

Cat.No: T22301

Synonym: CTP354,CTP354 (C-21191),C-21191

Target: GABA Receptor

Cat.No: T15014

Target: Histone Acetyltransferase

Cat.No: T8732

Target: Others, Mitochondrial Metabolism

5-Propargylamino-3'-azidomethyl-dCTP

Cat.No: T40771

5-Propargylamino-dCTP

Cat.No: T38546

Cat.No: T23778

5-Propargylamino-ddCTP

Cat.No: T38526

ddCTP trisodium

Cat.No: T63602

Cat.No: T75376

Cat.No: T70387

Cat.No: T40759

Cat.No: T75387

Cat.No: T74365

Cytidine 5'-diphosphate disodium

Cat.No: T31163

Synonym: CDP sodium salt,Cytidine 5'-diphosphate disodium salt,胞苷-5'-二磷酸二钠盐,Cytidine diphosphate sodium salt

Target: Others

Cat.No: T0033

Synonym: HePC,米替福新,Hexadecyl phosphocholine

Target: Akt, HIV Protease, PKC

5-Azacytidine 5′-triphosphate sodium

Cat.No: T83295

Cat.No: T74145

Cat.No: T10677

Target: Others

5-Azacytidine 5′-triphosphate

Cat.No: T83296

5-Methylcytidine 5′-triphosphate

Cat.No: T74584

5-Methylcytidine 5′-triphosphate trisodium

Cat.No: T74585

β-Endorphin (rat)

Cat.No: T35460

α-D-Glucose-1-phosphate (sodium salt hydrate)

Cat.No: T35416

NHC-diphosphate triammonium

Cat.No: T36881

Cat. No.	Product Name	Target	Signaling Pathways
T5288	Cytidine-5'-triphosphate disodium 胞苷 5'-三磷酸二钠盐,CTP,Cytidine 5'-triphosphate (disodium salt)	Others; Endogenous Metabolite	Metabolism; Others
	Cytidine-5'-triphosphate disodium (CTP) 是内源性代谢产物的一种。
T40426	Cytidine 5'-diphosphate trisodium salt CDP,胞苷5'-二磷酸三钠盐水合物,胞苷-5-二磷酸三钠盐,胞苷-5'-二磷酸三钠盐	Others	Others
	Cytidine 5'-diphosphate trisodium salt (CDP) 可通过尿苷单磷酸激酶 (UMPK) 催化将磷酸基从 ATP 转移到胞苷一磷酸 (CMP) 生成用于合成 DNA 和 RNA 的胞苷三磷酸。
T4758	2'-Deoxycytidine Cytosine deoxyribonucleoside,2'-Deoxycytidine monohydrate,2(1H)-Pyrimidinone,Cytosine deoxyriboside,Deoxyribose cytidine,Deoxycytidine,2'-脱氧胞嘧啶核苷一水合物	Endogenous Metabolite	Metabolism
	2'-Deoxycytidine (Deoxyribose cytidine) 是由胞嘧啶和脱氧核糖组成的DNA的主要核苷之一。核苷仅由与嘌呤或嘧啶碱相连的戊糖组成，没有磷酸基团。当N1与脱氧核糖的C1连接时，由胞嘧啶和脱氧核糖形成脱氧核苷和核苷酸；脱氧胞苷单磷酸(dCMP)，脱氧胞苷二磷酸(dCDP)，脱氧胞苷三磷酸(dCTP)。CTP是RNA(核糖核酸)中胞苷的来源，脱氧胞苷三磷酸(dCTP)是DNA(脱氧核糖核酸)中脱氧胞苷的来源。

天然产物

Cytidine-5'-triphosphate disodium

Cat.No: T5288

Synonym: 胞苷 5'-三磷酸二钠盐,CTP,Cytidine 5'-triphosphate (disodium salt)

Target: Others, Endogenous Metabolite

Cytidine 5'-diphosphate trisodium salt

Cat.No: T40426

Synonym: CDP,胞苷5'-二磷酸三钠盐水合物,胞苷-5-二磷酸三钠盐,胞苷-5'-二磷酸三钠盐

Target: Others

2'-Deoxycytidine

Cat.No: T4758

Synonym: Cytosine deoxyribonucleoside,2'-Deoxycytidine monohydrate,2(1H)-Pyrimidinone,Cytosine deoxyriboside,Deoxyribose cytidine,Deoxycytidine,2'-脱氧胞嘧啶核苷一水合物

Target: Endogenous Metabolite

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